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Resistance of Influenza a Viruses to Amantadine and Rimantadine

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Advances in Molecular Biology and Targeted Treatment for AIDS

Abstract

Numerous clinical studies carried out over the years have documented the efficacy of amantadine and rimantadine in the prophylaxis and treatment of influenza A infections 1–9. Although initially licensed in 1966, the use of amantadine in both the United States and the United Kingdom has been limited. Rimantadine, more widely used in the Soviet Union in recent years3 has recently been licensed in France and awaits approval for use in the United States. The reticence to use these agents has been due to several factors, not least the extreme specificity of the drugs for influenza A viruses and the lack of any benefit against influenza B infections which are responsible for a significant proportion of recurrent disease in the human population. This has not, however, precluded the successful prophylactic use of amantadine following identification of influenza A outbreaks to limit their spread within semi-closed communities such as boarding schools and nursing homes8,9. Initial concerns regarding adverse side-effects have now largely been allayed and rimantadine which causes a lower incidence of neurological reactions1,10,11 is now generally perceived as the drug of choice.

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Authors and Affiliations

  1. National Institute for Medical Research, The Ridgeway, Mill Hill, London, NW7 1AA, UK

    Alan J. Hay, Setareh Grambas & Michael S. Bennett

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  1. Alan J. Hay
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  2. Setareh Grambas
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  1. The George Washington University Medical Center, Washington, D.C., USA

    Ajit Kumar

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© 1991 Plenum Press, New York

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Hay, A.J., Grambas, S., Bennett, M.S. (1991). Resistance of Influenza a Viruses to Amantadine and Rimantadine. In: Kumar, A. (eds) Advances in Molecular Biology and Targeted Treatment for AIDS. GWUMC Department of Biochemistry Annual Spring Symposia. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-5928-9_32

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  • DOI: https://doi.org/10.1007/978-1-4684-5928-9_32

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4684-5930-2

  • Online ISBN: 978-1-4684-5928-9

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