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The Effects of Ethanol, Tumor Necrosis Factor, and Granulocyte Colony-Stimulating Factor on Lung Antibacterial Defenses

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Drugs of Abuse, Immunity, and Immunodeficiency

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 288))

Abstract

Respiratory tract infections are major causes of morbidity and mortality in individuals abusing alcohol (1). Sir William Osler, in his Principles and Practice of Medicine, stated that alcoholism was “perhaps the most potent predisposing factor” to bacterial pneumonia (2). Since this early observation, numerous other clinical investigations have reported evidence that alcoholics are at increased risk for severe pneumonia (3, 4). Despite recent technologic advances in the management of these infections and ever more “potent” antibiotics, there has been little decline in the mortality associated with this disease in alcohol consuming patients.

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Authors and Affiliations

  1. Departments of Medicine and Physiology, Louisiana State University Medical Center, New Orleans, Louisiana, USA

    Steve Nelson, Gregory Bagby, Chester Nakamura, Judd Shellito & Warren Summer

  2. Amgen, Inc., Thousand Oaks, California, USA

    Jeff Andresen

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  1. Steve Nelson
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  2. Gregory Bagby
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  3. Jeff Andresen
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  4. Chester Nakamura
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  5. Judd Shellito
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  6. Warren Summer
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Editor information

Editors and Affiliations

  1. The University of South Florida, Tampa, Florida, USA

    Herman Friedman , Steven Specter  & Thomas W. Klein ,  & 

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© 1991 Plenum Press, New York

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Nelson, S., Bagby, G., Andresen, J., Nakamura, C., Shellito, J., Summer, W. (1991). The Effects of Ethanol, Tumor Necrosis Factor, and Granulocyte Colony-Stimulating Factor on Lung Antibacterial Defenses. In: Friedman, H., Specter, S., Klein, T.W. (eds) Drugs of Abuse, Immunity, and Immunodeficiency. Advances in Experimental Medicine and Biology, vol 288. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-5925-8_28

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  • DOI: https://doi.org/10.1007/978-1-4684-5925-8_28

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4684-5927-2

  • Online ISBN: 978-1-4684-5925-8

  • eBook Packages: Springer Book Archive

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