Abstract
It has been recognized that DNA supercoiling is an essential factor in the maintainan a of the chromosomal state and cellular growth of bacteria.1–3 Supercoiling plays an important role in the interaction with a large number of proteins and hence influences the cellular processes such as replication, recombination, transcription and repair. In prokaryotes, DNA supercoiling is controlled by the action of two enzymes, DNA gyrase and DNA topoisomerase I. Gyrase, a type II topoisomerase produces negative DNA supercoils and can remove negative as well as positive supercoils.1–3 Topoisomerase I relaxes negatively supercoiled DNA and counteracts the supercoiling activity of gyrase.2,3 Studies on DNA topoisomerases, their enzymatic properties and inhibitory effects of various agents have been reported for different microorganisms.1–4 Topoisomerases from E.coli are the most extensively investigated enzymes.1,3,5
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© 1991 Plenum Press, New York
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Störl, K., Störl, J., Zimmer, C. (1991). DNA Topoisomerases from Streptomyces and Their Inhibition by Some Antibiotic and Antitumoractive Agents. In: Baumberg, S., Krügel, H., Noack, D. (eds) Genetics and Product Formation in Streptomyces . Federation of European Microbiological Societies Symposium Series, vol 55. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-5922-7_38
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DOI: https://doi.org/10.1007/978-1-4684-5922-7_38
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