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Cephamycin Production by Streptomyces Clavuligerus

  • Chapter
Book cover Genetics and Product Formation in Streptomyces

Part of the book series: Federation of European Microbiological Societies Symposium Series ((FEMS,volume 55))

Abstract

The classical β-lactam antibiotics can be divided into hydrophobic and hydrophilic fermentation products. The hydrophobic members, e.g. benzylpenicillin (penicillin G) and phenoxymethylpenicillin (penicillin V), contain non-polar side chains, e.g. phenylacetate and phenoxyacetate, respectively, and are made only by filamentous fungi; the best known of these is Penicillium chrysogenum. The hydrophilic types are penicillin N, cephalosporins and 7-a-methoxycephalosporins (cephamycins) which are made by fungi, actinomycetes and unicellular bacteria. They all contain the polar side chain, D-α-aminoadipate.

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Author information

Authors and Affiliations

  1. Department of Biology, Massachusetts Institute of Technology, Cambridge, MA, 02139, USA

    A. L. Demain

  2. Northeastern University, Boston, MA, 02115, USA

    J. M. Piret

Authors
  1. A. L. Demain
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  2. J. M. Piret
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Editors and Affiliations

  1. University of Leeds, Leeds, UK

    Simon Baumberg

  2. Institut für Mikrobiologie und Experimentelle Therapie, Jena, Germany

    Hans Krügel  & Dieter Noack  & 

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© 1991 Plenum Press, New York

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Demain, A.L., Piret, J.M. (1991). Cephamycin Production by Streptomyces Clavuligerus . In: Baumberg, S., Krügel, H., Noack, D. (eds) Genetics and Product Formation in Streptomyces . Federation of European Microbiological Societies Symposium Series, vol 55. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-5922-7_12

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  • DOI: https://doi.org/10.1007/978-1-4684-5922-7_12

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