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Isolation of Candida Albicans Histidine Auxotroph (HIS 4) and Characterization of Its Etiologic Gene

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Candida and Candidamycosis

Part of the book series: Federation of European Microbiological Societies Symposium Series ((FEMS,volume 50))

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Abstract

The clinical importance of C. albicans requires the development of a genetic system in this organism for better understanding of its mechanism(s) of pathogenesis and to eventually develop improved therapies for candidal infection. Our previous studies focused on the attachment of the fungus to host mammalian tissues1–3. Those studies involved a specific C. albicans isolate-CBS562. We considered it important to develop a genetic system in this strain. Consequently, we describe herewith the isolation of an histidine auxotroph (his4), and isolation, characterization and chromosomal location of the homologous HIS4 gene.

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References

  1. E. Segal, CRC Crit. Rev. Microhiol., 14, 229 (1987).

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  3. H. Sandovsky-Losica, E. Segal in: “Proceedings of FEMS-Symposium on Candida and Candidamycosis”, E.Tümbay, H.P.R. Seeliger and Ö. Ang, eds., Plenum Publishing House, London (1990).

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Author information

Authors and Affiliations

  1. Department of Human Microbiology, Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel

    S. Gottlieb & E. Segal

  2. Department of Clinical Microbiology, Hadassah Medical Center, Jerusalem, Israel

    G. Lebens & I. Polacheck

  3. Department of Microbiology, Israel Institute of Biological Research, Ness-Ziona, Israel

    Z. Altboum

Authors
  1. S. Gottlieb
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  2. E. Segal
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  3. G. Lebens
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  4. I. Polacheck
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  5. Z. Altboum
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Editor information

Editors and Affiliations

  1. Ege University, Izmir, Turkey

    Emel Tümbay

  2. University of Würzburg, Würzburg, Germany

    Heinz P. R. Seeliger

  3. Istanbul University, Istanbul, Turkey

    Özdem Anǧ

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© 1991 Plenum Press, New York

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Gottlieb, S., Segal, E., Lebens, G., Polacheck, I., Altboum, Z. (1991). Isolation of Candida Albicans Histidine Auxotroph (HIS 4) and Characterization of Its Etiologic Gene. In: Tümbay, E., Seeliger, H.P.R., Anǧ, Ö. (eds) Candida and Candidamycosis. Federation of European Microbiological Societies Symposium Series, vol 50. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-5910-4_26

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  • DOI: https://doi.org/10.1007/978-1-4684-5910-4_26

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4684-5912-8

  • Online ISBN: 978-1-4684-5910-4

  • eBook Packages: Springer Book Archive

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