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Pharmacological Characterization of Sigma Binding Sites in Guinea Pig Brain Membranes

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Neuroreceptor Mechanisms in Brain

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 287))

Abstract

The pharmacological, biochemical and behavioral characterization of sigma binding sites is currently the focus of intense investigation. First described by Martin and his colleagues (1976) to account for the behavioral effects of selected benzomorphan opiates, sigma binding sites were originally classified as an opioid receptor subtype. Subsequent work suggested this designation was inaccurate since, unlike opioid receptors, the sigma site is insensitive to blockade by naloxone (Itzhak et al., 1985; Katz et al., 1985). In addition, the (+) isomers of opiates such as pentazocine and N-allylnormetazocine (SKF 10,047) are more active at sigma binding sites, while opiate receptors are typically more responsive to (-) isomers (Weber et al., 1986).

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Authors and Affiliations

  1. Nova Pharmaceutical Corporation, 6200 Freeport Centre, Baltimore, MD, 21224-2788, USA

    E. W. Karbon & S. J. Enna

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  1. E. W. Karbon
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  2. S. J. Enna
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Editor information

Editors and Affiliations

  1. Division of Health Sciences, University of the Air, 2-11 Wakaba, Chiba 260, Japan

    Shozo Kito

  2. Department of Pharmacology Institute of Pharmaceutical Sciences, Hiroshima University School of Medicine, 1-2-3 Kasumi, Minami-ku Hiroshima 734, Japan

    Tomio Segawa

  3. Department of Pharmacology Center for Health Sciences, University of California-Los Angeles School of Medicine, Los Angeles, California, 90024, USA

    Richard W. Olsen

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© 1991 Plenum Press, New York

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Karbon, E.W., Enna, S.J. (1991). Pharmacological Characterization of Sigma Binding Sites in Guinea Pig Brain Membranes. In: Kito, S., Segawa, T., Olsen, R.W. (eds) Neuroreceptor Mechanisms in Brain. Advances in Experimental Medicine and Biology, vol 287. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-5907-4_5

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  • DOI: https://doi.org/10.1007/978-1-4684-5907-4_5

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4684-5909-8

  • Online ISBN: 978-1-4684-5907-4

  • eBook Packages: Springer Book Archive

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