Abstract
The acidic amino acids L-aspartic acid (ASP) and, in particular, L-glutamic acid (GLU) are generally accepted to be the major excitatory amino acid (EAA) neurotransmitters in the mammalian central nervous system (CNS). Hyperactivity of central EAA neuronal pathways has been associated with the etiology of certain neurodegenerative diseases, such as status epilepticus, Huntington’s chorea and dementia of the Alzheimer type (Lodge, 1988; Rothman and Olney, 1986; Greenamyre 1986; Greenamyre et al., 1988; Bridges et al., 1988). In Alzheimer patients a regional degeneration of cholinergic, noradrenergic and serotonergic neurones is observed (Narang and Cutler, 1986).
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References
Bridges, R. J., Geddes, J. W., Monaghan, D. T., and Cotman, C. W., 1988, Excitatory amino acid receptors in Alzheimer’s disease, in “Excitatory Amino Acids in Health and Disease,” D. Lodge, ed., J. Wiley&Sons, Chichester, pp. 321–335.
Coyle, J. T., 1983, Neurotoxic action of kainic acid, J. Neurochem., 41: 1–11.
Deutsch, S. I., Mastropaolo, J., Schwartz, B. L., Rosse, R. B., and Morihisa, J. M., 1989, A “glutamatergic hypothesis” of schizophrenia: rationale for pharmacotherapy with glycine, Clin. Neuropharmacol., 12:1–13.
Greenamyre, J. T., 1986, The role of glutamate in neurotransmission and in neurologic disease, Arch. Neurol., 43:1058–1063.
Greenamyre, J. T., Maragos, W. F., Albin, R. L., Penney, J. B., and Young, A. B., 1988, Glutamate transmission and toxicity in Alzheimer’s disease, Prog. Neuro-Psychopharmacol. Biol. Psychiat., 12:421–430.
Hansen, J. J. and Krogsgaard-Larsen, P., 1990, Structural, conformational, and stereochemical requirements of central excitatory amino acid receptors, Med. Res. Rev., 10:55–94.
Johnson, R. L. and Koerner, J. F., 1988, Excitatory amino acid neurotransmission, J. Med. Chem., 31:2057–2066.
Krogsgaard-Larsen, P., Brehm, L., Johansen, J. S., Vinzents, P., Lauridsen, J., and Curtis, D. R., 1985, Synthesis and structure-activity studies on excitatory amino acids structurally related to ibotenic acid, J. Med. Chem., 28:673–679.
Krogsgaard-Larsen, P., Honoré, T., Hansen, J. J., Curtis, D. R., and Lodge, D., 1980, New class of glutamate agonists structurally related to ibotenic acid, Nature (London), 284:64–66.
Krogsgaard-Larsen, P., Nielsen, E. O., and Curtis, D. R., 1984, Ibotenic acid analogues. Synthesis and biological in vitro activity of confor-mationally restricted agonists at central excitatory amino acid receptors, J. Med. Chem., 27:585–591.
Lodge, D., ed., 1988, “Excitatory Amino Acids in Health and Disease”, J. Wiley&Sons, Chichester.
Madsen, U., Brehm, L., Schaumburg, K., Jorgensen, F. S., and Krogsgaard-Larsen, P., 1990, Relationship between structure, conformational flexibility and biological activity of agonists and antagonists at the N-methyl-D-aspartic acid subtype of excitatory amino acid receptors, J. Med. Chem., 33:374–380.
McLennan, H., 1983, Receptors for the excitatory amino acids in the mammalian central nervous system, Prog. Neurobiol., 20:251–271.
Narang, P. K. and Cutler, N. R., 1986, Pharmacotherapy in Alzheimer’s disease: basis and rationale, Prog. Neuropsychopharmacol. Biol. Psychiat., 10:519–531.
Nielsen, E. O., Schousboe, A., Hansen, S. H., and Krogsgaard-Larsen, P., 1985, Excitatory amino acids: studies on the biochemical and chemical stability of ibotenic acid and related compounds, J. Neurochem., 45:725–731.
Rothman, S. M. and Olney, J. W., 1986, Glutamate and the pathology of hypoxic/ischemic brain damage, Ann. Neurol., 19:105–111.
Shinozaki, H., 1988, Pharmacology of the glutamate receptor, Prog. Neurobiol., 30:399–435.
Watkins, J. C., Krogsgaard-Larsen, P., and Honoré, T., 1990, Structure-activity relations in the development of excitatory amino acid receptor agonists and competitive antagonists, Trends Pharmacol. Sci., 11:25–33.
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© 1991 Plenum Press, New York
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Ebert, B., Madsen, U., Johansen, T.N., Krogsgaard-Larsen, P. (1991). NMDA Receptor Agonists: Relationships between Structure and Biological Activity. In: Kito, S., Segawa, T., Olsen, R.W. (eds) Neuroreceptor Mechanisms in Brain. Advances in Experimental Medicine and Biology, vol 287. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-5907-4_42
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DOI: https://doi.org/10.1007/978-1-4684-5907-4_42
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