Abstract
Calcitonin gene-related peptide (CGRP) is a peptide that is synthesized in nervous tissues by a different processing of the messenger RNA for calcitonin (Amara et al.,1982; Rosenfeld et al.,1983) . A wide, but non-random distribution of CGRP-like immunoreactive structures in the central and peripheral nervous system has been demonstrated by immunohistochemistry and radioimmunoassay (Rosenfeld et al.,1983; Gibson et al.,1984; Kawai et al.,1985). CGRP has been shown to cause physiological responses and to have specific binding sites, suggesting that it is a neurotransmitter or neuromodulator.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Amara, S. G., Jones, V., Rosenfeld, M. G., Ong, E. S., and Ewans, R. M., 1982, Alternative RNA processing in calcitonin gene expression generate mRNA encoding different polypeptide products, Nature, 298:240–244.
Barsony, J., and Marx, S. J., 1988, Dual effects of calcitonin and calcitonin gene-related peptide on intracellular cyclic AMP in a human breast cancer cell line. Endocrinology, 122:1218–1223.
Carlsen, R. C., 1975, The possible role of cyclic AMP in the neurotrophic control of skeletal muscle. J.Physiol., 247:343–361.
Fambrough, G. H., 1970, Acetylcholine sensitivity of muscle fiber membrane: Mechanism of regulation by motoneurons. Science, 168:372.
Fontaine, B., Klarsfeld, A., Hokfelt, T., and Changeux, J. -P., 1986, Calcitonin gene-related peptide, a peptide present in spinal cord motoneurons, increases the number of acetylcholine receptors in primary cultures of chick embryo myotubes. Neurosci. Lett., 71:51–65.
Gibson, S. J., Polak, J. ML., Bloom, S. R., Sabate, I. M., Mulderry, P. M., Chatei, M. A., McGregor, G. P., Morrison, J. F. B., Kelly, J. S., Evans, R. M., and Rosenfeld, M. G., 1984, Calcitonin gene-related peptide immunoreactivity in spinal cord of man and of eight other species. J. Neuroscience, 4:3101–3111.
Gibson, S. J., Polak, J. M., Giaid, A., Hamid, Q. A., Kar, S., Jones, P. M., Denny, P., Legon, S., Amara, S. G., Craig, R. K., Bloom, S. R., Penketh, R. J. A., Rodek, C., Ibrachim, N. B. N., and Dawson, A., 1988, Calcitonin gene-related peptide messenger RNA is expressed in sensory neurones of dorsal root ganglia and also in spinal motoneurons in man and rat. Neurosci. Lett., 91:283–288.
Grampp, W., Harms, J. B., and Thesleff, S., 1972, Inhibition of denervation changes in skeletal muscle by blockers of protein synthesis. J. Physiol. 221:743–745.
Hashimoto, K., Watanabe, Y., Uchida S., and Yoshida, H., 1989A, Increase in the amount of adenylate cyclase in rat gastrocnemius muscle after denervation. Life Sci., 44:1887–1895.
Hashimoto, K., Uchida, S., and Yoshida, H., 1989B, Effects of calcitonin gene-related peptide on the adenylate cyclase system in cultured rat skeletal muscle cells. Life Sci. 45:2183–2193.
Hoshi, T., Garber, S. S., and Aldrich, R. W., 1988, Effect of forskolin on voltage-gated potassium channels is independent of adenylate cyclase activation. Science, 240:1652–1655.
Kawai, Y., Takami, K., Shiosaka, S., Emson, P. C., Hillyard, C. J., McIntyre, I., and Tohyama, M., 1985, Topographic localization of calcitonin generelated peptide in rat brain : An immunohistochemical analysis. Neuroscience, 15:747–763.
Kobayashi, H., Hashimoto, K., Uchida, S., Sakuma, J., Takami, K., Tohyama, M., Izumi, F., and Yoshida, H., 1987, Calcitonin gene-related peptide stimulates adenylate cyclase activity in rat striated muscle. Experientia, 43:314–316.
Lentz, T. L., 1972, A role of cyclic AMP in a neurotropic process. Nature (New Biology), 238:154–155.
New, H. V., and Mudge, A.V., 1986, Calcitonin gene-related peptide regulates muscle acetylcholine receptor synthesis. Nature, 323:129–135.
Rosenfeld, M. G., Mermod, J. J., Amara, S. G., Swanson, L. W., Sawchenko, P. E., River, J., Vale, W. W., and Evans, R. M., 1983, Production of novel neuropeptide encoded by the calcitonin gene via tissue specific RNA processing. Nature, 304:129–135.
Takami, K., Kawai, Y., Shiosaka, S., Lee, Y., Girgis, S., Hillyard, C. J., MacIntyre, I., Emson P. C., and Tohyama, M., 1985A, Immunohistochemical evidence for coexistence of calcitonin gene-related peptide-and choline acetyltransferase-like immunoreactivity in neurons of the rat hypoglossal, facial and ambiguus nuclei. Brain Res., 328:386–389.
Takami, K., Kawai, Y., Uchida, S., Tohyama, M., Shiotani, Y., Yoshida, H., Emson, P. C., Girgis, S., Hillyard, C. J., and MacIntyre, I., 1985B, Effect of calcitonin gene-related peptide on contraction of striated muscle in the mouse. Neurosci. Lett., 60:227–230.
Takami, K., Hashimoto, K., Uchida, S., Tohyama M., and Yoshida, H., 1986, Effect of calcitonin gene-related peptide on the cyclic AMP level of isolated mouse diaphragm. Jpn. J. Pharmacol., 42:345–350.
Tsujimoto, T., and Kuno, M., 1988, Calcitonin gene-related peptide prevents disuse-induced sprouting of rat motor nerve terminals. J. Neurosci., 8:3951–3957.
Uchida, S., Yamamoto, H., Iio, S., Matsumoto, N., Wang, X. -B., Yonehara, N., Imai, Y., Inoki, R., and Yoshida, H., in press, Release of CGRP-like immunoreactive substance from neuromuscular junction by nerve excitation and its action on striated muscle. J. Neurochem.,
Wadzinski, B. E., Shanahan, M. F., and Ruoho, A. E., 1987, Derivatization of the human erythrocyte glucose transporter using a novel forskolin photoaffinity label. J. Biol. Chem., 262:17683–17689.
Wagoner, P. K., and Pallotta, B. S., 1988, Modulation of acetylcholine receptor desensitization by forskolin is independent of cyclic AMP. Science 240:1656–1657.
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1991 Plenum Press, New York
About this chapter
Cite this chapter
Uchida, S., Takami, K., Kobayashi, H., Hashimoto, K., Matsumoto, N. (1991). Functions of a Co-Transmitter, Calcitonin Gene-Related Peptide, on the Neuromuscular Junction. In: Kito, S., Segawa, T., Olsen, R.W. (eds) Neuroreceptor Mechanisms in Brain. Advances in Experimental Medicine and Biology, vol 287. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-5907-4_4
Download citation
DOI: https://doi.org/10.1007/978-1-4684-5907-4_4
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4684-5909-8
Online ISBN: 978-1-4684-5907-4
eBook Packages: Springer Book Archive