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Neuroreceptor Mechanisms in Brain pp 279–294Cite as

Regulation of the Nicotinic Acetylcholine Receptor by Serine and Tyrosine Protein Kinases

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Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 287))

Abstract

Neurotransmitter receptors play a central role in the process of signal transduction across synapses between neurons. Neurotransmitters released from the presynaptic neuron diffuse across the synaptic cleft and bind to neurotransmitter receptors in the membrane of the postsynaptic neuron. The neurotransmitter receptors then transduce this signal across the postsynaptic membrane either by directly activating ion channels or by regulating the level of intracellular second messengers in the postsynaptic neuron. Because of the essential role of neurotransmitter receptors in synaptic transmission, the short and long term modulation of neurotransmitter receptor function could be an extremely effective mechanism for the regulation of synaptic plasticity. What are the molecular mechanisms that may be involved in the modulation of neurotransmitter receptor function? Studies on the regulation of cellular metabolism over the past four decades have shown that protein phosphorylation is the primary mechanisms in the regulation of almost all cellular processes (Edelman et al, 1987, Nairn et al, 1985, Hunter et al, 1985).

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Author information

Authors and Affiliations

  1. Howard Hughes Medical Institute, Department of Neuroscience, The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA

    Richard L. Huganir

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  1. Richard L. Huganir
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Editors and Affiliations

  1. Division of Health Sciences, University of the Air, 2-11 Wakaba, Chiba 260, Japan

    Shozo Kito

  2. Department of Pharmacology Institute of Pharmaceutical Sciences, Hiroshima University School of Medicine, 1-2-3 Kasumi, Minami-ku Hiroshima 734, Japan

    Tomio Segawa

  3. Department of Pharmacology Center for Health Sciences, University of California-Los Angeles School of Medicine, Los Angeles, California, 90024, USA

    Richard W. Olsen

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© 1991 Plenum Press, New York

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Huganir, R.L. (1991). Regulation of the Nicotinic Acetylcholine Receptor by Serine and Tyrosine Protein Kinases. In: Kito, S., Segawa, T., Olsen, R.W. (eds) Neuroreceptor Mechanisms in Brain. Advances in Experimental Medicine and Biology, vol 287. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-5907-4_23

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  • DOI: https://doi.org/10.1007/978-1-4684-5907-4_23

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4684-5909-8

  • Online ISBN: 978-1-4684-5907-4

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