Implications of Thiolester Linked Fatty Acids in Apolipoprotein B

  • Diana M. Lee
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 285)


Apolipoprotein B (ApoB) is obligatory for triglyceride transport. Why ApoB is singled out among all apolipoproteins is not well understood. ApoB is the most hydrophobic apolipoprotein among all known apolipoproteins. It has the highest tendency to undergo aggregation. If one examines the amino acid composition of ApoB it resembles any other common water-soluble protein. Why, then, is ApoB so hydrophobic? We believe that the thiolester 1 2 bound fatty acids recently found in ApoB1,2 may play an important role in contributing to the hydrophobic nature of ApoB.


Sindbis Virus Human Apolipoprotein Vesicular Stomatitis Virus Glycoprotein Fatty Acid Acylation Hydropathy Index 
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Copyright information

© Plenum Press, New York 1990

Authors and Affiliations

  • Diana M. Lee
    • 1
  1. 1.Lipoprotein and Atherosclerosis Research ProgramOklahoma Medical Research FoundationOklahoma CityUSA

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