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Implications of Thiolester Linked Fatty Acids in Apolipoprotein B

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Hypercholesterolemia, Hypocholesterolemia, Hypertriglyceridemia, in Vivo Kinetics

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 285))

Abstract

Apolipoprotein B (ApoB) is obligatory for triglyceride transport. Why ApoB is singled out among all apolipoproteins is not well understood. ApoB is the most hydrophobic apolipoprotein among all known apolipoproteins. It has the highest tendency to undergo aggregation. If one examines the amino acid composition of ApoB it resembles any other common water-soluble protein. Why, then, is ApoB so hydrophobic? We believe that the thiolester 1 2 bound fatty acids recently found in ApoB1,2 may play an important role in contributing to the hydrophobic nature of ApoB.

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Author information

Authors and Affiliations

  1. Lipoprotein and Atherosclerosis Research Program, Oklahoma Medical Research Foundation, 825 N.E. 13th Street, Oklahoma City, OK, 73104, USA

    Diana M. Lee

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  1. Diana M. Lee
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Editor information

Editors and Affiliations

  1. Research Foundation on Atherosclerosis, B-1000, Brussels, Belgium

    Claude L. Malmendier

  2. Lipoprotein and Atherosclerosis Resaerch Program, Oklahoma Medical Research Foundation, Oklahoma City, Oklahoma, 73104, USA

    P. Alaupovic

  3. Molecular Disease Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland, 20892, USA

    H. Bryan Brewer Jr.

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© 1990 Plenum Press, New York

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Lee, D.M. (1990). Implications of Thiolester Linked Fatty Acids in Apolipoprotein B. In: Malmendier, C.L., Alaupovic, P., Brewer, H.B. (eds) Hypercholesterolemia, Hypocholesterolemia, Hypertriglyceridemia, in Vivo Kinetics. Advances in Experimental Medicine and Biology, vol 285. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-5904-3_5

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  • DOI: https://doi.org/10.1007/978-1-4684-5904-3_5

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4684-5906-7

  • Online ISBN: 978-1-4684-5904-3

  • eBook Packages: Springer Book Archive

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