Abstract
The aggregation of coronary artery disease (CAD) within families is well established 14,13,10 and concordance rates for the disease are known to be higher in mono -than dizygotic twins, 2,3.
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References
Abbott RD, Caroll RJ. Interpreting multiple logistic regression coefficients in prospective observational studies. Am J. Epidemiol 1984; 119:830–836.
Berg K. Genetics of coronary heart disease. In: Steinberg AE, Brown AG, Motulsky AR, Childs B Eds. Prog Med Genet 1983; 35 -90.
Berg K. Twin studies of coronary heart disease and its risk factors. Actor Med Gemell 1984; 33: 349 -361.
Castelli COP. The triglyceride issue: a view from Framingham. Am Heart J 1986; 112: 432 -437.
Chamberlain JC, Thorn JA, Oka K et al. DMA polymorphisms at the lipoprotein lipase gene. Associations in normal and hypertriglyceridaemic subjects. Atherosclerosis 1989; 75: 85–91.
Fischer L, Fitzgerald GA, Lawn RM. Two polymorphisms in the human lipoprotein lipase gene. Nucleic Acids Res 1987; 15: 7657.
Heinzmann G, Ladias J, Antonarakis S et al. RFLP for the human lipoprotein lipase gene: Hind-III. Nucleic Acids Res 1987: 15; 6763.
Kirchgessner TG, Chuat JG, Heinzmann Get al. Organisation of the human lipoprotein lipase gene and evolution of the lipase gene family. Proc Natl Acad Sci USA 1989; 86: 9647 -9651.
Hulley SB, Rosenmann AM, Bawol RD, Brand RJ. Epidemiology as a guide to clinical decisions. The associations between triglyceride and coronary heart disease. NEJ Med 1980; 302: 1383–1389.
Nora JJ, Lortscher RM, Spangler RD, Nora AH, Kimberling WJ. Genetic-epidaemiologic study of early onset ischaemic heart disease. Circulation 1980; 61: 503 -508.
Patsch JR, Prasad S, Gotto AM Jr, Patsch W. HDL2 relationships of the plasma levels of this lipoprotein species to its composition, to the magnitude of postprandial lipaemia and to the activities of lipoprotein lipase and hepatic lipase. J Clin Invest 1987: 80: 341 -347.
Rees A, Shoulders CC, Stocks J, Galton DJ, Baralle FE. DNA polymorphisms adjacent to human apolipoprotein A-I gene: relation to hypertriglyceridaemia. Lancet 1983; i: 444 -446.
Rissanen AM. Familial aggregation of coronary heart disease in a high incidence area (North Karelia, Finland). Br Heart J 1979; 42: 294 -303.
Slack J, Evans KA. The increased risk of death from ischaemic heart disease in first-degree relatives of 121 men and 96 women with ischaemic heart disease. J Med Genet 1966; 3: 239 -259.
Thorn JA, Chamberlain JC, Stocks J, Galton DJ. RFLP’s at the lipoprotein and hepatic lipase gene loci in coronary athero sclerosis. Proceedings of the Fifth European Symposium on Metabolism. Atherosclerosis 1989; in press.
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© 1990 Plenum Press, New York
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Chamberlain, J.C. et al. (1990). Genetic Variation at the Lipoprotein Lipase Gene Associates with Coronary Arteriosclerosis. In: Malmendier, C.L., Alaupovic, P., Brewer, H.B. (eds) Hypercholesterolemia, Hypocholesterolemia, Hypertriglyceridemia, in Vivo Kinetics. Advances in Experimental Medicine and Biology, vol 285. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-5904-3_32
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DOI: https://doi.org/10.1007/978-1-4684-5904-3_32
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