Kinetic Studies of the Origin of Apolipoprotein (APO) B-100 in Low Density Lipoproteins of Normal and Watanabe Heritable Hyperlipidemic (WHHL) Rabbits
Numerous studies in humans, as well as in experimental animals, support the general conclusion that low density lipoproteins (1.02 <d<1.06 g/ml; LDL) are a product of the metabolism of hepatogenous triglyceride-rich precursor particles of lower density, mainly by the action of lipolytic enzymes (lipoprotein lipase and, perhaps, hepatic lipase) on component triglycerides and phospholipids (1). From kinetic studies in humans, the concept has developed that this process occurs progressively, by conversion of large very low density lipoproteins (VLDL) to lipoproteins of progressively higher density in a lipolytic cascade (2).
KeywordsCholesteryl Ester Density Gradient Ultracentrifugation Extravascular Compartment Multicompartmental Model Intravascular Compartment
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