Abstract
During the last two decades major advances have occurred in our understanding of lipoprotein metabolism in normal subjects, and patients with dyslipoproteinemias. Of particular interest has been the elucidation of the role of plasma apolipoproteins, lipoproteins receptors, transfer factors, and lipolytic enzymes in the metabolism of plasma lipoproteins. An improved understanding of the regulation of lipoprotein metabolism, and the intracellular as well as extracellular transport of cholesterol has permitted the determination of molecular defects in patients with dyslipoproteinemias. This new information has been used to development improved methods for diagnosis and treatment of patients at risk for the development of hyperlipidemia and premature cardiovascular disease. This report will summarize recent studies in our laboratory on three apolipoproteins, apoA-I, apoB, and Lp(a).
This is a preview of subscription content, log in via an institution.
Buying options
Tax calculation will be finalised at checkout
Purchases are for personal use only
Learn about institutional subscriptionsPreview
Unable to display preview. Download preview PDF.
References
T. Gordon, W.P. Castelli, M.C. Hjortland, W.B. Kannel, and T.R. Dawber Am. J. Med. 62:707–714 (1977).
G. Heiss, N.J. Johnson, S. Reiland, L.E. Davis, and H.A. Tyroler Circulation 62:IV-116-IV–136 (1980).
W.P. Castelli, J.T. Dougle, T. Gordon, C.G. Hames, M.C. Hjortland, S.B. Hulley, A. Kagan, and W.J. Zukel Circulation 55:767–772 (1977).
P. Avogaro, B.G. Bittolo, G. Cazzaloto, and E. Rosa Atherosclerosis 37:69–76 (1980).
J.L.H.L. Third, J. Montag, M. Flynn, J. Freidel, P. Laskarzewski, and C.J. Glueck Metabolism 33:136–146 (1984) .
J.A. Glomset J. Lipid Res. 9:155–167 (1968).
R.J. Havel, H.A. Eder, and J.H. Bragdon J. Clin. Invest34:1345–1353 (1955).
D.L. Sprecher, L. Taam, and H.B. Brewer, Jr. Clin. Chem30:2084–2092 (1984).
G. Utermann, G. Ferissner, G. Franceschini, J. Hass, A. Steinmetz J. Biol. Chem. 257:501–507 (1982).
H.J. Menzel, R.G. Kladetzky, and G. Assmann J. Lipid Res23:915–922 (1982).
J.J. Albers, G.R. Warnick, and A.V. Nichols. Clinical and Metabolic Aspects of High Density Lipoproteins, ed. N.E. Miller and G.J. Miller. Elsevier 1984 pp. 381–414.
P. Alaupovic. Protides of Biol. Fluids Proc. Colloq19:9–19 (1972).
J. Osborne and H.B. Brewer, Jr. Adv. Prot. Chem. 31:253–337 (1977).
P. Puchois, A. Kandoussi, P. Fievet, J.L. Fourrin, M. Bertrand, E. Koren, J.C. Fruchart. Atherosclerosis 68:35–40 (1987).
R. Barbaras, P. Puchois, J.C. Fruchart, and G. Aihaud. Biochem. Biophys. Res. Comm. 142:63–69 (1987).
D.J. Rader Circulation
K. Higuchi, A.V. Hospattankar, S.W. Law, N. Meglin, J. Cortright, and H.B. Brewer, Jr. Proc. Natl. Acad. Sci85:1772–1776 (1988).
J.M. Hoeg, D.D. Sviridov, G.E. Tennyson, S.J. Demosky, Jr., M.D. Meng, D. Bojanovski, I.G. Safonova, V.S. Repin, M.B. Kuberger, N.V. Smirnov, K. Higuchi, R.E. Gregg, H.B. Brewer, Jr. J. Lipid Res. In press.
L.M. Powell, S.C. Wallis, R.J. Pease, Y.H. Edwards, T.S. Knott, and J. Scott. Cell 50:831–840 (1987).
A.V. Hospattankar, K. Higuchi, S.W. Law, N.M. Meglin, and H.B. Brewer, Jr. Biochem. Biophys. Res. Comm. 148:279–285 (1987).
S.H. Chen, G. Habib, C.Y. Yang, Z.W. Gu, B.R. Lee, S.A. Weng, S.R. Silberman, S.J. Cai, J.P. Deslypere, M. Rosseneu, A.M. Gotto, Jr., W.H. Li, and L. Chan Science238:363–366 (1987).
G.E. Tennyson, C.A. Sabatos, K. Higuchi, N. Meglin, and H.B. Brewer, Jr. Proc. Natl. Acad. Sci. USA 86:500–504 (1989).
N.O. Davidson, L.M. Powell, S.C. Wallis, and J. Scott J. Biol. Chem. 263:13482–13485 (1988).
K. Berg Acta Path 59:369–382 (1963).
G.M. Kostner, P. Avogaro, G. Cazzolato, E. Marth, G. Bittolo-Bon, and G.B. Qunici Atherosclerosis 38:51–61 (1981) .
V.W. Armstrong, P. Cremer, E. Eberle, A. Menke, F. Schulze, H. Wieland, H. Kreuzer, and D. Seidel Atherosclerosis 62:249–257 (1986).
G.G. Rhoads, G. Dahlen, K. Berg, N.E. Morton, and A.L. Dannenberg. J. Am. Med. Assoc. 256:2540–2544 (1986).
G.M. Kostner. In Low Density Lipoproteins, ed. C.E. Day and R.S. Levy, Plenun Press, New York. (1976) pp. 229–269.
J.W. Ganbatz, C. Heideman, A.M. Gotto, J.D. Morrisett, and G.H. Dahlen J. Biol. Chem. 254:4582–4589 (1983).
G. Utermann and W. Weber FEBS Lett. 154:357–361 (1983).
G.M. Fless, C.A. Rolih, and A.M. Scanu J. Biol. Chem259:11470–11478 (1984).
J.W. McLean, J.E. Tomlenson, W.J. Keeang, D.L. Eaton, E.Y. Chen, G.M. Fless, A.M. Scanu, and R.M. Lawn Nature330:132–137 (1987).
M.L. Koschinsky, U. Beisiegel, D. Henne-Bruns, D.L. Eaton, and R.M. Lawn Biochem. 29:640–644 (1990).
G. Utermann Science 246:904–910 (1990).
G. Utermann, H.J. Mengel, H.G. Kraft, H.C. Duba, H.G. Kemmler, and C. Seitz J. Clin. Invest. 80:458–465 (1987).
G. Utermann, F. Hoppichles,H. Dieplinger, M. Seed, G. Thompson, and E. Boerwinkle Proc. Natl. Acad. Sci. USA86:4171–4174 (1989).
K. Maatmann-Moe and K. Berg Clin. Genet. 20:352–362 (1981).
A.W. Mann, H.O. Kraft, R.E. Gregg, D.J. Rader, J.R. Schaefer, L.A. Zech, J.M. Hoeg, J. Davignon, and H.B. Brewer, Jr. J. Clin. Invest. In press.
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1990 Plenum Press, New York
About this chapter
Cite this chapter
Brewer, H.B., Rader, D.J., Hoeg, J.M., Mann, A., Tennyson, G. (1990). Recent Advances in Lipoprotein Metabolism and the Genetic Dyslipoproteinemias. In: Malmendier, C.L., Alaupovic, P., Brewer, H.B. (eds) Hypercholesterolemia, Hypocholesterolemia, Hypertriglyceridemia, in Vivo Kinetics. Advances in Experimental Medicine and Biology, vol 285. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-5904-3_29
Download citation
DOI: https://doi.org/10.1007/978-1-4684-5904-3_29
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4684-5906-7
Online ISBN: 978-1-4684-5904-3
eBook Packages: Springer Book Archive