Origin of Cholesterol and Bile Acids in the Diverted Bile of Two Patients with Total Small Bowel Resection
An isotope study of cholesterol and bile acid metabolism was carried out in two patients who had undergone home cyclic parenteral nutrition for several months after total small bowel resection. This rare steady-state situation implies that cholesterol is eliminated from the body by an external biliary fistula which replaces the fecal output of cholesterol and bile acids that occurs in healthy subjects. This study gave evidence that newly synthesized hepatic cholesterol becomes the main source of cholesterol and bile acids eliminated into the bile in patients with nil digestive function and total interruption of the bile acid cycle.
KeywordsBile Acid Plasma Cholesterol Biliary Cholesterol Healthy Subjects4 Internal Secretion
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