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Mechanisms of Hypocholesterolemia

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Hypercholesterolemia, Hypocholesterolemia, Hypertriglyceridemia, in Vivo Kinetics

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 285))

Abstract

Although clinically significant hypocholesterolemia occurs less frequently than hypercholesterolemia, it has usually important conse quences that involve derangement of major metabolic roles of lipoproteins.

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References

  1. The Lipid Research Clinics Program Epidemiology Committee: Plasma lipid distributions in selected north american populations: the lipid research clinics program prevalence study. Circulation., 60:427 (1979).

    Google Scholar 

  2. B. V. Howard, M. P. Davis, D. J. Pettitt, W. C. Knowler, and P. H. Bennett, Plasma and lipoprotein cholesterol and triglyceride concentrations in the Pima Indians: distributions differing from those of Caucasians, Circulation, 68:714 (1983).

    Article  PubMed  CAS  Google Scholar 

  3. W. J. McConathy and D. M. Lane, Studies on the apolipoproteins and lipoproteins of cord serum, Pediat. Res., 14:757 (1980).

    Article  PubMed  CAS  Google Scholar 

  4. B. Christensen, C. Glueck, P. Kwiterovich, I. Degroot, G. Chase, G. Heiss, R. Mowery, I. Tamir, and B. Rifkind, Plasma cholesterol and triglyceride distributions in 13,665 children and adolescents: the Prevalence study of the lipid research clinics program, Pediat. Res.,14:194 (1980).

    Article  PubMed  CAS  Google Scholar 

  5. H. A. Tyroler, C. J. Glueck, B. Christensen, and P. O. Kwiterovich, Plasma high-density lipoprotein cholesterol comparisons in black and white populations. The Lipid research clinics program prevalence study, Circulation, 62, IV–99 (1980).

    Google Scholar 

  6. W. E. Connor, M. T. Cequeira, R. U. Connor, R. B. Wallace, R. Malinow, and H. R. Casdorph, The plasma lipids, lipoproteins and diet of the Tarahumara Indians of Mexico, Am. J. Clin. Nutr., 31–1131 (1978).

    Google Scholar 

  7. J. Burslem, G. Schonfeld, M. A. Howald, S. W. Weidman, and J. P. Miller, Plasma apoprotein and lipoprotein lipid levels in vegetarians, Metabolism, 27:711 (1978).

    Article  PubMed  CAS  Google Scholar 

  8. F. M. Sacks, D. Ornish, B. Rosner, S. McLanahan, W. P. Castelli, and E. H. Kass, Plasma lipoprotein levels in vegetarians. The effect of ingestion of fats from dairy products, J.A.M.A., 254:1337 (1985).

    Article  PubMed  CAS  Google Scholar 

  9. E. J. Schaefer, R. I. Levy, N. D. Ernst, F. D. Van Sant, and H. B. Brewer, Jr., The effects of low cholesterol, high polyunsaturated fat, and low fat diets on plasma lipid and lipoprotein cholesterol levels in normal and hypercholesterolemic subjects, Am. J. Clin. Nutr., 34:1758 (1981).

    PubMed  CAS  Google Scholar 

  10. L. A. Carlson and B. Philipson, Fish-eye disease, a new familial condition with massive corneal opacities and dyslipoproteinemia, Lancet, ii:921 (1979).

    Article  Google Scholar 

  11. G. Franceschini, C. Sirtori, A. Capurso, K. H. Weisgraber, and R. W. Mahley, A-I Milano apoprotein, J. Clin. Invest., 66:892 (1980).

    Article  PubMed  CAS  Google Scholar 

  12. E. Gjone, Familial LCAT deficiency, Acta. Med. Scand., 194:353 (1973).

    Article  PubMed  CAS  Google Scholar 

  13. P. Alaupovic, E.J. Schaefer, W. J. McConathy, J. D. Fesmire, and H. B. Brewer, Jr., Plasma apolipoprotein concentrations in familial apolipoprotein A-I and A-II deficiency (Tangier disease), Metabolism, 30:805 (1981).

    Article  PubMed  CAS  Google Scholar 

  14. E. J. Schaefer, W. H. Heaton, M. G. Wetzel, and H. B. Brewer, Jr., Plasma apolipoprotein A-I absence associated with a marked reduction of high density lipoproteins and premature coronary artery disease, Arteriosclerosis, 2:16 (1982).

    Article  PubMed  CAS  Google Scholar 

  15. D. R. Illingworth, W. E. Connor, and P. Alaupovic, High density lipo protein metabolism in a patient with abetalipoproteinemia, Ann. Nutr. Metab., 25:1 (1981).

    Article  PubMed  CAS  Google Scholar 

  16. J -F. Lontie, C. L. Malmendier, C. Sérougne, D. Y. Dubois, C. Dachet, J. Férézou, and D. Mathé, Plasma lipids, lipoproteins and apolipoproteins in two kindreds of hypobetalipoproteinemia, Atherosclerosis, 1990. To be published.

    Google Scholar 

  17. C. L. Malmendier, J -F. Lontie, C. Delcroix, C. Sérougne, J. Férézou, and L. M. Veiga, Low density lipoprotein metabolism in a kindred with familial hypobetalipoproteinemia, Submitted to Metabolism, 1990.

    Google Scholar 

  18. C. L. Malmendier, C. Delcroix, J -F. Lontie, D. Y. Dubois, Apolipoprotein C-II and C-III metabolism in a kindred of familial hypobetalipoproteinemia, Submitted to Metabolism, 1990.

    Google Scholar 

  19. T. Magot, K. Ouguerram, J -F. Lontie, and C. L. Malmendier, In vivo study of lipoprotein cholesteryl ester movements between plasma lipoproteins in familial hypobetalipoproteinemia, Congrés du Gerli, Nice, April 1990.

    Google Scholar 

  20. A. L. Truswell, J. D. L. Hansen, C. E. Watson, and P. Uannenburg, Relation of serum lipids and lipoproteins to fatty liver in kwashiorkor, Am. J. Clin. Nutr., 22:568 (1969).

    PubMed  CAS  Google Scholar 

  21. D. Lemonnier and Y. Ingenbleek, Les carences nutritionnelies dans les pays du Tiers Monde, GERM, Paris, Karthala-ACCT (1990)

    Google Scholar 

  22. D. Bekaert, R. Kallel, M -E. Bouma, J -F. Lontie, A. Mebazaa, C. L. Malmendier, and M. Ayrault-Jarrier, Plasma lipoproteins in infantile visceral leishmaniasis: deficiency of apolipoproteins A-I and A-II, Clin. Chim. Acta, 184:181 (1989).

    Article  PubMed  CAS  Google Scholar 

  23. C. A. Rouzer and A. Cerami, Hypertriglyceridemia associated with Trypanosoma brucei infection in rabbits: role of defective triglyceride removal, Mol. Biochem. Parasitol., 2:31 (1980).

    Article  PubMed  CAS  Google Scholar 

  24. B. Beutler and A. Cerami, Tumor necrosis, cachexia, shock, and inflammation: a common mediator, Ann. Rev. Biochem., 57:505 (1988).

    Article  PubMed  CAS  Google Scholar 

  25. P. Scuderi, K. E. Sterling, K. S. Lam, P. R. Finley, K. J. Ryan, C. G. Ray, E. Petersen, D. J. Slymen, and S. E. Salmon, Raised serum levels of tumor necrosis factor in parasitic infections, Lancet, ii:1364 (1986).

    Article  Google Scholar 

  26. G. Assman, D. Fredrickson, P. Herbert, T. Forte, R. Heinen, An A-II lipoprotein particle in Tangier disease, Circulation, 50:259 (1974).

    Google Scholar 

  27. W. März and W. Gross, Immunochemical evidence for the presence in human plasma of lipoproteins with apolipoprotein A-II as the major protein constituant, Biochem. Biophys. Acta, 962:155 (1988).

    PubMed  Google Scholar 

  28. M. R. Rifkin, Interaction of high-density lipoprotein with trypanosoma brucei: effect of membrane stabilizers, J. Cell. Biochem., 23:57 (1983).

    Article  PubMed  CAS  Google Scholar 

  29. B. Galvao-Castro, J. A. Sa Ferreira, K. F. Marzochi, M. C. Marzochi, S. G. Coutinho, and P. H. Lambert, Polyclonal B-cell activation, circulating immune complexes and autoimmunity in human visceral leishmaniasis, Clin. Exp. Immunol., 56:58 (1984).

    PubMed  CAS  Google Scholar 

  30. B. M. Rifkind and M. Gale, Hypolipidaemia in anaemia, Lancet, ii:640 (1967).

    Article  Google Scholar 

  31. H. S. Gilbert, H. Ginsberg, R. Fagerstrom, and W. V. Brown, Characterization of hypocholesterolemia in myeloproliferative disease. Relation to disease manifestations and activity, Am. J. Med., 71:595 (1981).

    Article  PubMed  CAS  Google Scholar 

  32. R. E. Bases and I. H. Krakoff, Studies of serum cholesterol levels in leukemia, J. Reticuloendoth. Soc, 2:8 (1965).

    CAS  Google Scholar 

  33. Y. K. Ho, R. G. Smith, M. S. Brown, and J. L. Goldstein, Low-density lipoprotein (LDL) receptor activity in human acute myelogenous leukemia cells, Blood, 52:1099 (1978).

    PubMed  CAS  Google Scholar 

  34. H. Ginsberg, H. S. Gilbert, J. C. Gibson, N -A. Le, and W. V. Brown, Increased low-density-lipoprotein catabolism in myeloproliferative disorders, Ann. Intern. Med., 96:311 (1982).

    PubMed  CAS  Google Scholar 

  35. S. Vitols, M. Björkholm, G. Gahrtob, and C. Peterson, Hypocholesterolaemia in malignancy due to elevated low-densitylipoprotein-receptor activity in tumor cells: evidence from studies in patients with leukaemia, Lancet, i:1150 (1989).

    Google Scholar 

  36. U. E. Nydegger and R. E. Butler, Serum lipoprotein levels in patientswith cancer, Cancer Res., 32:1756 (1972).

    PubMed  CAS  Google Scholar 

  37. J -F. Lontie and C. L. Malmendier, unpublished observations.

    Google Scholar 

  38. C. L. Malmendier, J -F. Lontie, J. P. Soulier, and D. Y. Dubois, Modifications of plasma lipids, lipoproteins and apolipoproteins in advanced cancer patients treated with recombinant interleukin-2 and autologous lymphokine-activated killer cells, Atherosclerosis, 73:173 (1988).

    Article  PubMed  CAS  Google Scholar 

  39. S. A. Rosenberg, M. T. Lotze, L. M. Muul, S. Leitman, A. E. Chang, S. E. Ettinghausen, Y. L. Matory, J. M. Skibber, E. Shiloni, J. T. Vetto, C. A. Seipp, C. Simpson, and C. M. Reichert, Observations on the systemic administration of autologous lymphokine-activated killer cells and recombinant interleukin-2 to patients with metastatic cancer, N. Engl. J. Med., 313:1485 (1985).

    Article  PubMed  CAS  Google Scholar 

  40. J. A. Cuthbert and P. E. Lipski, Promotion of human T lymphocyte activation and proliferation by fatty acids in low density and high density lipoproteins, Proc. Natl. Acad. Sci. USA, 81:4539 (1984).

    Article  PubMed  CAS  Google Scholar 

  41. M. T. Lotze, Y.L. Matory, S.E. Ettinghausen, A.A. Rainer, S. 0. Sharrow, C. A. Y. Seipp, M. C. Custer, and S. A. Rosenberg, In vivo administration of purified human interleukin 2. II. Half life, immunologic effects, and expansion of peripheral lymphoid cells in vivo with recombinant IL2, J. Immunol., 135:2865 (1985).

    PubMed  CAS  Google Scholar 

  42. D. E. Wilson, G. R. Birchfield, J. S. Hejazi, J. P. Ward, and W. E. Samlowski, Hypocholesterolemia in patients treated with recombinant interleukin-2: appearance of remnant-like lipoproteins, J. Clin. Oncol., 7:1573 (1989)

    PubMed  CAS  Google Scholar 

  43. M. L. Sherman, D. R. Spriggs, K. A. Arthur, K. Imamura, E. Frei III, and D. W. Kufe, Recombinant human tumor necrosis factor administered as a five-day continuous infusion in cancer patients: Phase I toxicity and effects on lipid metabolism, J. Clin. Oncol., 6:344 (1988).

    PubMed  CAS  Google Scholar 

  44. S. D. Nimer, R. E. Champlin, and D. W. Golde, Serum cholesterol-lowering activity of granulocyte-macrophage colony-stimulating factor, JAMA, 260:3297 (1988).

    Article  PubMed  CAS  Google Scholar 

  45. C. Ehnholm, K. Aho, J. K. Huttunen, E. Kostiainen, K. Mattila, J. Pikkarainen, and K. Cantell, Effect of interferon on plasma lipoproteins and on the activity of postheparin plasma lipases, Arteriosclerosis, 2:68 (1982).

    Article  PubMed  CAS  Google Scholar 

  46. I. B. Rosenzweig, D. A. Wiebe, E. C. Borden, B. Storer, and E. S. Shrago, Plasma lipoprotein changes in humans induced by ß-interferon, Atherosclerosis, 67:261 (1987).

    Article  PubMed  CAS  Google Scholar 

  47. R. Kurzrock, M. F. Rohde, J. R. Quesada, S. H. Gianturco, W. A. Bradley, S. A. Sherwin, and J. U. Gutterman, Recombinant ß interferon induces hypertriglyceridemia and inhibits post-heparin lipase activity in cancer patients, J. Exp. Med., 164:1093 (1986).

    Article  PubMed  CAS  Google Scholar 

  48. C. L. Malmendier, J -F. Lontie, D. Y. Dubois, and D. Math6, Lipids and apolipoproteins in liver transplanted patients, In preparation.

    Google Scholar 

  49. C. J. Glueck, P. Gartside, R. W. Fallat, J. Sielski, and P.M. Steiner, Longevity syndromes: familial hypobeta and familial hyperalphalipoproteinemia, J. Lab. Clin. Med., 88:941 (1976).

    PubMed  CAS  Google Scholar 

  50. M. S. Brown and J.L. Goldstein, A receptor-mediated pathway for cholesterol homeostasis, Science, 232:34 (1986).

    Article  PubMed  CAS  Google Scholar 

  51. C. B. Blum, R. J. Deckelbaum, L. D. Witte, A. R. Tall, and J. Cornicelli, Role of apolipoprotein E-containing lipoproteins in abetalipoproteinemia, J. Clin. Invest., 70:1157 (1982).

    Article  PubMed  CAS  Google Scholar 

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Authors and Affiliations

  1. Fondation de Recherche sur l’Athérosclérose, Brussels, Belgium

    C. L. Malmendier, J.-F. Lontie & D. Y. Dubois

Authors
  1. C. L. Malmendier
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  2. J.-F. Lontie
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  3. D. Y. Dubois
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Editor information

Editors and Affiliations

  1. Research Foundation on Atherosclerosis, B-1000, Brussels, Belgium

    Claude L. Malmendier

  2. Lipoprotein and Atherosclerosis Resaerch Program, Oklahoma Medical Research Foundation, Oklahoma City, Oklahoma, 73104, USA

    P. Alaupovic

  3. Molecular Disease Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland, 20892, USA

    H. Bryan Brewer Jr.

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© 1990 Plenum Press, New York

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Malmendier, C.L., Lontie, JF., Dubois, D.Y. (1990). Mechanisms of Hypocholesterolemia. In: Malmendier, C.L., Alaupovic, P., Brewer, H.B. (eds) Hypercholesterolemia, Hypocholesterolemia, Hypertriglyceridemia, in Vivo Kinetics. Advances in Experimental Medicine and Biology, vol 285. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-5904-3_22

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  • DOI: https://doi.org/10.1007/978-1-4684-5904-3_22

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4684-5906-7

  • Online ISBN: 978-1-4684-5904-3

  • eBook Packages: Springer Book Archive

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