Metabolic Role of Human Apoprotein A-IV
Compared with the other human apoproteins, physiological variations and metabolic functions of apo A-IV remain obscure. The apo A-IV has been discovered in rat HDL and has been later found in human plasma, mesenteric lymph and interstitial fluid. Apo A-IV is synthetized by intestine and liver and is catabolized by liver and kidneys. As apo A-IV has been suspected to play a role in triglyceride transport, we undertook the study of its plasma concentration in a population of subjects with various plasma triglyceride levels. Moreover, recent studies brought some evidence for an implication of apo A-IV in the reverse cholesterol transport. Because recent reports suggested that HDL was the major lipoprotein class involved in this metabolic pathway, we investigated the structural and metabolic relation between apo A-IV and HDL.
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- 6.N. A. Elshourbagy, M. S. Boguski, W. S. L. Liao, L. S. Jefferson, J. I. Gordon, and J. M. Taylor, Expression of rat apolipoprotein A-IV and A-I genes : mRNA induction during development and in response to glucocorticoids and insulin, Proc. Natl. Acad. Sci. USA, 82:8242 (1985).PubMedCrossRefGoogle Scholar