Skip to main content
SpringerLink
Log in

Transcriptional Regulation of the Human Apolipoprotein Genes

  • Chapter
Hypercholesterolemia, Hypocholesterolemia, Hypertriglyceridemia, in Vivo Kinetics

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 285))

Abstract

The transcription of eukaryotic genes is controlled by the interaction of regulatory gene sequences (promoter elements) with specific nuclear proteins (transcription factors) (1–3). The interaction of the transcription factors with the promoter elements controls: a) tissue specific gene expression (4–6); b) gene expression during differentiation and development (7,8); and c) gene expression in response to intracellular and extracellular stimuli such as hormones and metabolites (9–12).

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 39.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 54.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

Reference

  1. Maniatis, T., S. Goodbourn, J.A. Fischer. 1987. Science 236: 1237–1245.

    Article  PubMed  CAS  Google Scholar 

  2. Briggs, M.R., Kadonaga, J.T., Bell, S.P., and Tjian, R. (1986) Science 234, 47–52.

    Article  PubMed  CAS  Google Scholar 

  3. Jones, N.C., Rigby, P.W.J., and Ziff, E.B. (1988) Genes & Development 2, 267–281.

    Article  CAS  Google Scholar 

  4. Gorski, K., Carneiro, M., and Schibler, U (1986) Cell 27, 767–776.

    Article  Google Scholar 

  5. Cereghini, S., Raymondjean, M., Carranca, A.J., Herbomel, P., and Yaniv, M. (1987) Cell 50, 627–638.

    Article  PubMed  CAS  Google Scholar 

  6. Monaci, P., Nicosia, A., and Cortese, R. (1988) EMBO J. 7, 2075–2087.

    PubMed  CAS  Google Scholar 

  7. Treisman, P. (1986) Cell 46, 567–574.

    Article  PubMed  CAS  Google Scholar 

  8. Atchison, M.L., and Perry, R.P. (1987) Cell 48, 121–128.

    Article  PubMed  CAS  Google Scholar 

  9. Lenardo, M., Pierce, J.W., and Baltimore, D. (1987) Science 236, 1573–1577.

    Article  PubMed  CAS  Google Scholar 

  10. Montminy, M.R., and Bilezikjian, L.M. (1987) Nature 328, 175–178.

    Article  PubMed  CAS  Google Scholar 

  11. Hurst, H.C., and Jones, N.C. (1987) Genes Dev. 1, 1132.

    Article  PubMed  CAS  Google Scholar 

  12. Sudhof, T.C., Russell, D.W., Erown, M.S., and Goldstein, J.L. (1987) Cell 48, 1061–1069.

    Article  PubMed  CAS  Google Scholar 

  13. Gorman, C.M., Moffat, L.F., Howard, B.H. (1982) Mol. Cell. Biol. 2, 1044–151.

    PubMed  CAS  Google Scholar 

  14. Staudt, L.M., Singh, H., Sen, R., Sirth, T., Sharp, P.A., and Baltimore, D. (1986) Nature 323, 640–643.

    Article  PubMed  CAS  Google Scholar 

  15. Fried, M., and Crothers, D.M. (1981) Nucl. Acids Res. 9, 6505–6525.

    Article  PubMed  CAS  Google Scholar 

  16. Strauss, F., and Varshavsky, A. (1984) Cell 37, 889–901 .

    Article  PubMed  CAS  Google Scholar 

  17. Maxam, A.M., and Gilbert, W. (1977) Proc. Natl. Acad. Sci. USA 74, 560–564.

    Article  PubMed  CAS  Google Scholar 

  18. Kadonaga, J.T., and Tjian, R. (1986) Proc. Natl. Acad. Sci. USA 83, 5889–5893.

    Article  PubMed  CAS  Google Scholar 

  19. Briggs, M.R., Kadonaga, J.T., Bell, S.P., and Tjian, P. (1986) Science 234, 47.

    Article  PubMed  CAS  Google Scholar 

  20. Jones, K.A., Kadonaga, J.T., Rosenfeld, P.J., Kelly, T.J., and Tjian, R.T. (1987) Cell 48, 79–89.

    Article  PubMed  CAS  Google Scholar 

  21. Rosenfeld, P.J., Kelly, T.J. (1986) J. Eiol. Chem. 261, 1398–1408.

    CAS  Google Scholar 

  22. Lee, W., Mitchell, P., and Tjian, R. (1987) Cell 49, 741–752.

    Article  PubMed  CAS  Google Scholar 

  23. Kadonaga, J.T., Carner, K.R., Masiarz, S.R., and Tjain, R. (1987) Cell 51, 1079–1909.

    Article  PubMed  CAS  Google Scholar 

  24. Santoro, C., Mermod, N., Andrews, P.C., and Tjian, R. (1988) Nature 334, 218–224.

    Article  PubMed  CAS  Google Scholar 

  25. Singh, H., LeBowitz, J.H., Baldwin, A.S., Jr., and Sharp, P.A. (1988) Cell 52, 415–423.

    Article  PubMed  CAS  Google Scholar 

  26. Windmueller, H.G., Herbert, P.N., and Levy, R.I. (1973) J. Lipid Res. 14, 215–223.

    PubMed  CAS  Google Scholar 

  27. Felker, T.E., Fainaru, M., Hamilton, R.L., and Havel, R.J. (1977) J. Lipid Res. 18, 465–473.

    PubMed  CAS  Google Scholar 

  28. Wu, A.L., and Windmueller, H.G. (1979) J. Biol. Chem. 254, 7316–7322.

    PubMed  CAS  Google Scholar 

  29. Zannis, V.I., Breslow, J.L., SanGiacomo, T.R., Aden, D.P., and Knowles, B.B. (1981) Biochemistry 20, 7089–7096.

    Article  PubMed  CAS  Google Scholar 

  30. Zannis, V.I., Kurnit, D., and Breslow, J.L. (1982) J. Biol. Chem. 257, 536–544.

    PubMed  CAS  Google Scholar 

  31. Zannis, V.I., Cole, S.F., Jackson, C, Kurnit, D.M., and Karathanasis, S.K. (1985) Biochemistry 24, 4450–4455.

    Article  PubMed  CAS  Google Scholar 

  32. Newman, T.C., Dawson, P.A., Rudel, L.L., and Williams, D.L. (1985) J. Biol. Chem. 260, 2452–2457.

    PubMed  CAS  Google Scholar 

  33. Lenich, C., Brecher, P., Makrides, S., Chobanian, A., and Zannis, V.I. (1988) J. Lipid Res. 29, 755–764.

    PubMed  CAS  Google Scholar 

  34. Thomas, M.S., Prack, M.M., Dashti, N., Johnson, F., Rudel, L.L., and Williams, D.L. (1988) J. Biol. Chem. 263, 5183–5189.

    Google Scholar 

  35. Haddad, I.A., Ordovas, J.M., Fitzpatrick, T., and Karathanasis, S.K. (1986) J. Biol. Chem. 261, 13268–13277.

    PubMed  CAS  Google Scholar 

  36. Elshourbagy, N.A., Boguski, M.S., Liao,, W.S.L., Jefferson, L.S., Gordon, J.I., and Taylor, J.M. (1985) Proc. Natl. Acad. Sci. USA 82, 8242–8246.

    Article  PubMed  CAS  Google Scholar 

  37. Tam, S.P., Archer, T.K., and Deeley, R.G. (1986) Proc. Natl. Acad. Sci. USA 83, 3111–3115.

    Article  PubMed  CAS  Google Scholar 

  38. Sorci-Thomas, M., Prack, M.M., Dashti, N., Johnson, P., Rudel, L.L., and Williams, D.L. (1989) J. Lipid Res. 30, 1397–1403.

    PubMed  CAS  Google Scholar 

  39. Sastry, K.N., Seedorf, Udo, Karathanasis, S.K. (1988) Mol. Cell. Bio.. 8, 605–614.

    CAS  Google Scholar 

  40. Higuchi, K., Law, S.W., Hoeg , J.M., Schumacher, U.K., Neglin, N., and Brewer, H.B., Jr. (1988) 263, 18530–18536

    Google Scholar 

  41. Das, H.K., T. Leff, and J.L. Ereslow. 1988. J. Biol. Chem. 263: 11452–11458.

    PubMed  CAS  Google Scholar 

  42. Carlsson, P., and Bjursell, G. (1989) Gene 77, 113–121.

    Article  PubMed  CAS  Google Scholar 

  43. Reue, K., Leff, T., and Breslow, J.L. (1988) J. Biol. Chem. 263, 6857–6864.

    PubMed  CAS  Google Scholar 

  44. Leff, T., Reue, K., Melian, A., Culver, H., and Breslow, J.L. (1989) J. Biol. Chem. 264, 16132–16137.

    PubMed  CAS  Google Scholar 

  45. Smith, J.D., Nelian, A., Leff, T., and Breslow, J.L. (1988) J. Biol. Chem. 263, 8300–8308.

    PubMed  CAS  Google Scholar 

  46. Paik, Y.K., Chang, D.J., Reardon, C.A., Walker, M.D., Taxman, E., and Taylor, J.M. (1988) J. Biol. Chem. 263, 13340–13349.

    PubMed  CAS  Google Scholar 

  47. Kardassis, D., Hadzopoulou-Cladaras, M., Ramji, D.P., Cortese, R., Zannis, V.I., and Cladaras, C. (1990) Mol. Cell. Biol. 10, 2653–2659.

    PubMed  CAS  Google Scholar 

  48. Ogami, K., Hadzopoulou-Cladaras, M., Cladaras, C., and Zannis, V.I. (1990) J. Biol. Chem. In Press.

    Google Scholar 

  49. Chambaz, J., Cardot, P., Pastier, D., Roghani, A., Zannis, V., and Cladaras, C. (1990) Arteriosclerosis. In Press.

    Google Scholar 

  50. Papazafiri, P., Ramji, D., Ogami, K., Cladaras, C., Cortese, R., and Zannis, V.I. (1990) Arteriosclerosis. In Press .

    Google Scholar 

  51. Lucero, M.A., Sanchez, D., Ochoa, A.R., Brunei, F., Cohen, G.N., Baralle , F.E., and Zakin, M.M. (1989) Nucleic Acids Res. 17, 2283–2300.

    Article  PubMed  CAS  Google Scholar 

  52. Goldstein, J.L., and Brown, M.S. (1977) Ann. Rev. Biochem. 46:897–930.

    Article  PubMed  CAS  Google Scholar 

  53. Goldstein, J.L., and Brown, M.S. (1982) In: The Metabolic Basis of Inherited Disease, 5th ed. (J.E. Stanbury, J.B. Wyngaarden, D.S. Fredrickson, J.L. Goldstein, and M.S. Brown, eds.), pp. 672–712, McGraw-Hill, New York.

    Google Scholar 

  54. Cladaras, C., Hadzopoulou-Cladaras , M.., Nolte, R.T., Atkinson, D., and Zannis, V.I. (1986) The EMBO J. 5:3495–3507.

    CAS  Google Scholar 

  55. Law, S.W., Grant, S.M., Higuchi, K., Hospattankar , A., Lackner, K., Lee, N., and Brewer, H.B., Jr. (1986) Proc. Natl. Acad. Sci. USA 83, 8142–8146.

    Article  PubMed  CAS  Google Scholar 

  56. Yang, C.Y., Chen, S.H., Gianturco, S.H., Bradley, W.A., Sparrow, J.T., Tanimura, M., Li, W.L., Sparrow, D.A., DeLoof, H., Rosseneu, M., Lee, F.S., Gu, Z.W., Gotto, A.M., Jr., and Chan, L. (1986) Nature 323, 738–742.

    Article  PubMed  CAS  Google Scholar 

  57. Knott, T.J., Pease, R.J., Powell, L.M., Wallis, S.C., Rall, S.C., Jr., Innerarity, T.L., Blackhart, B., Taylor, W.H., Marcel, Y., Milne, R., Johnson, D., Fuller, M., Lusis, A.J., McCarthy, B.J., Mahley, R.W., Levy-Wilson, B., and Scott, J. (1986) Nature 323, 734–739.

    Article  PubMed  CAS  Google Scholar 

  58. Blackhart, B.D., Ludwig, E.M., Pierotti, V.R., Caiati, L., Onasch, M.A., Wallis, S.C., Powell, L., Pease, R., Knott, T.J., Chu, M.L., Mahley, R.W., Scott, J., McCarthy, B.J., and Levy-Wilson, B. (1986) J. Biol. Chem. 261, 15364–15367.

    PubMed  CAS  Google Scholar 

  59. Ludwig, E.H., Blackhart, B.D., Pierotti, V.R., Caiata, L., Fortier, C, Knott, T., Scott, J., Mahley, R.W., Levy-Wilson, B., and McCarthy, B.J. (1987) DNA 6, 363–372.

    Article  PubMed  CAS  Google Scholar 

  60. Yang, C.Y., Gu, Z.W., Weng, S.Q., Li, W.H., Gotto, A.M., Jr., and Chan, L. (1989) Arteriosclerosis 9, 96–108.

    Article  PubMed  CAS  Google Scholar 

  61. Demmer, L.A., Levin, M.S., Elovson, J., Reuben, M.A., Lusis. A.J., and Gordon, J.I. (1986) Proc. Natl. Acad. Sci. USA 83, 8102–8106.

    Article  PubMed  CAS  Google Scholar 

  62. Kannel, W.B., Castelli, W.P., and Gordon, T. (1979) Ann. Intern. Med. 90, 85–91.

    PubMed  CAS  Google Scholar 

  63. Heiss, G., and Tyroler, H. (1982) Proceedings of the Workshop on Apolipoprotein Quantification (U.S. Dept. of Health and Human Services, National Institutes of Health, Bethesda, MD), NIH Publ. No. 83–1266, 7–24.

    Google Scholar 

  64. Brunzell, J.D., Sniderman, A.D., Albers, J.J., and Kwiterovich, P.O., Jr. (1984) Arteriosclerosis 4:79–83.

    Article  PubMed  CAS  Google Scholar 

  65. Sniderman, A., Shapiro, S., Marpole, D., Skinner, B., Teng, B., and Kwiterovich, P.O., Jr. (1980) Proc. Natl. Acad. Sci. USA 77, 601–603.

    Article  Google Scholar 

  66. Siervogel, R.M., Morrison, J.A., Kelly, K., Meliles, M., Gartside, P., and Glueck, C. (1980) J. Clin. Genet. 17, 13.

    Article  CAS  Google Scholar 

  67. Steinberg, D., Grundy, S.M., Mok, H.Y.I., Turner, J.D., Weinstein, J.J., Brown, W.V., and Albers, J.J. (1979) J. Clin. Invest. 64, 292–301.

    Article  PubMed  CAS  Google Scholar 

  68. Young, S.G., Peralta, F.P., Dubois, B.W., Curtiss, L.K., Boyles, J. K., and Witztum, J.L. (1987) J. Biol. Chem. 262, 16604–16611.

    PubMed  CAS  Google Scholar 

  69. Brewer, H.B., Jr., Shulman, R., Herbert, P., Ronan, R., and Wehrly, K. (1974) J. Biol. Chem. 249, 4975–4984.

    PubMed  CAS  Google Scholar 

  70. Shulman, R. S., Herbert, P. N., Fredrickson, D. S., Wehrly, K., and Brewer, H. B., Jr. (1974) J. Biol. Chem. 249, 4969–4974.

    PubMed  CAS  Google Scholar 

  71. Herbert, P. N., Assmann, G., Gotto, A. M., Jr., and Fredrickson, D. S. (1982) In: The Metabolic Basis of Inherited Diseases (Stanbury, J.B., Wyngaarden, J.E., Fredrickson, D. S., Goldstein, J.L., and Brown, M.S., eds.), pp. 589–651, McGraw-Hill, New York.

    Google Scholar 

  72. Protter, A. A., Levy-Wilson, B., Miller, J., Bencen, G., White, T., and Seilhamer, J. (1984) DNA 3, 449–456.

    Article  PubMed  CAS  Google Scholar 

  73. Sharpe, C.R., Sidoli, A., Shelley, C.S., Lucero, M.A., Shoulders, C.C., and Baralle, F.E. (1984) Nucleic Acids Res. 12, 3917–3932.

    Article  PubMed  CAS  Google Scholar 

  74. Karathanasis , S.K., Zannis , V.I., and Breslow, J.L. (1985) J. Lipid Res. 26, 451–456.

    PubMed  CAS  Google Scholar 

  75. Brown, W.V., and Eaginsky, M.L. (1972) Biochem. Biophys. Res. Commun. 46, 375–382.

    Article  PubMed  CAS  Google Scholar 

  76. Krauss, R.M., Herbert, P.M., Levy, R.I., and Fredrickson, D. S. (1973) Circ. Res. 33, 403–411.

    PubMed  CAS  Google Scholar 

  77. Windier, E., Chao, Y., and Havel, R.J. (1980) J. Biol. Chem. 255, 5475–5480.

    Google Scholar 

  78. Shelburne, F., Hanks, J., Meyers, W., and Quarfordt, S. (1980) J. Clin. Invest. 64, 652–658.

    Article  Google Scholar 

  79. Quarfordt, S.H., Michalopoulos, G., and Schirmer, B. (1982) J. Biol. Chem. 257, 14642–14647.

    PubMed  CAS  Google Scholar 

  80. DeSimone, V., Ciliberto, G., HArdon, E.M., Paonessa, G., Palla, F., Lundberg, L., and Cortese, R. (1987) EMBO J. 6, 2759–2766.

    PubMed  Google Scholar 

  81. Makrides, S.C., Ruiz-Opazo, N., Hayden, M., Nussbaum, A.L., Breslow, J.L., and Zannis, V.I. (1988) Eur. J. Biochem. 173, 465–471.

    Article  PubMed  CAS  Google Scholar 

  82. Kardassis, D., Zannis, V., and Cladaras, C. (1990) Arteriosclerosis. In Press.

    Google Scholar 

  83. Parker, C.S., and Topol, J. (1984) Cell 37, 273–283.

    Article  PubMed  CAS  Google Scholar 

  84. Hardon, E.M., Frain, M., Paonessa, G., and Cortese, C. (1988) EMBO J. 7:1711–1719.

    PubMed  CAS  Google Scholar 

  85. Babiss, L.E., Herbst, R.S., Bennett, A.L., and Darnell, J.E. (1987) Gene Dev. 1, 256–267.

    Article  PubMed  CAS  Google Scholar 

  86. Courtois, G., Morgan, J.G., Campbell, L.A., Fourel, G., and Crabtree, G.R. (1987) Science 238, 688–692.

    Article  PubMed  CAS  Google Scholar 

  87. Courtois, G., Baumhueter, S., and Crabtree, G.R. (1988) Proc. Natl. Acad. Sci. USA 85, 7937–7941.

    Article  PubMed  CAS  Google Scholar 

  88. Lichtsteiner , S., and Schibler, U. (1989) Cell 57, 1179–1187.

    Article  PubMed  CAS  Google Scholar 

  89. Frain, M., Swart, G., Monaci, P., Nicosia, A., Stampfli, S., Frank, R., and Cortese, R. (1989) Cell 59, 145–157.

    Article  PubMed  CAS  Google Scholar 

  90. Goodburn, S., Burstein, H., and Maniatis, T. (1986) Cell 45, 601–610.

    Article  Google Scholar 

  91. Elshourbagy, N.A., Walker, D.W., Paik, Y.K., Boguski, M.S., Freeman, M., Gordon, J.L., and Taylor, J.M. (1987) J. Biol. Chem. 262, 7963–7981.

    Google Scholar 

  92. Ciliberto, G., Dente, L., and Cortese, R. (1985) Cell 41, 531–540.

    Article  PubMed  CAS  Google Scholar 

  93. Ogami, K., Kardassis, D., Cladaras, C., and Zannis, V.I. (1990) Arteriosclerosis. In Press.

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Section of Molecular Genetics Cardiovascular Institute Departments of Medicine and Biochemistry, Boston University Medical Center, Boston, MA, 02118, USA

    Vassilis I. Zannis, Dimitris Kardassis, Kinya Ogami, Margarita Hadzopoulou-Cladaras & Christos Cladaras

Authors
  1. Vassilis I. Zannis
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Dimitris Kardassis
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Kinya Ogami
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Margarita Hadzopoulou-Cladaras
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Christos Cladaras
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Research Foundation on Atherosclerosis, B-1000, Brussels, Belgium

    Claude L. Malmendier

  2. Lipoprotein and Atherosclerosis Resaerch Program, Oklahoma Medical Research Foundation, Oklahoma City, Oklahoma, 73104, USA

    P. Alaupovic

  3. Molecular Disease Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland, 20892, USA

    H. Bryan Brewer Jr.

Rights and permissions

Reprints and permissions

Copyright information

© 1990 Plenum Press, New York

About this chapter

Cite this chapter

Zannis, V.I., Kardassis, D., Ogami, K., Hadzopoulou-Cladaras, M., Cladaras, C. (1990). Transcriptional Regulation of the Human Apolipoprotein Genes. In: Malmendier, C.L., Alaupovic, P., Brewer, H.B. (eds) Hypercholesterolemia, Hypocholesterolemia, Hypertriglyceridemia, in Vivo Kinetics. Advances in Experimental Medicine and Biology, vol 285. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-5904-3_1

Download citation

  • DOI: https://doi.org/10.1007/978-1-4684-5904-3_1

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4684-5906-7

  • Online ISBN: 978-1-4684-5904-3

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation