Abstract
In alcohol toxicity, a lot of data point to genetic factors associated with environmental factors. These genetic factors can intervene at different levels : genetic variability in the distribution of polymorphic alcohol and aldehyde dehydrogenase isozymes (Bosron, et al., 1988) could play a role in determining individual difference in ethanol metabolism and toxicity. In the future, other polymorphisms in alcohol metabolism may be described. Polymorphism is also to be considered in detoxication and/or target organ metabolism (as collagen polymorphism in alcoholic cirrhosis)(Weiner, et al., 1988).
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© 1990 Plenum Press, New York
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Couzigou, P. et al. (1990). Role of Alcohol Dehydrogenase Polymorphism in Ethanol Metabolism and Alcohol-Related Diseases. In: Weiner, H., Wermuth, B., Crabb, D.W. (eds) Enzymology and Molecular Biology of Carbonyl Metabolism 3. Advances in Experimental Medicine and Biology, vol 284. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-5901-2_28
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DOI: https://doi.org/10.1007/978-1-4684-5901-2_28
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