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Enzymology and Molecular Biology of Carbonyl Metabolism 3 pp 119–127Cite as

cDNA Cloning and Expression of Human Aldose Reductase

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Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 284))

Abstract

Aldose reductase (ALR2; EC 1.1.1.21), a member of the monomeric NADPH-dependent aldoketoreductase family, has been strongly suggested to play a key role in the development of various diabetic complications (Gabbay et al., 1966; Engerman and Kern, 1984; Nishimura et al., 1987; Kinoshita and Nishimura, 1988).

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Author information

Authors and Affiliations

  1. Dept. of Pediatric Pharmacol., Natl. Children’s Med. Res. Ctr., Tokyo, Japan

    Chihiro Nishimura, Takashi Yamaoka & Tai Akera

  2. Dept. of Vet. Sci., Natl. Institute of Health, Tokyo, Japan

    Yoshiharu Matsuura

  3. Div. of Biol. Chem., Natl. Institute of Hygienic Sci., Tokyo, Japan

    Tsuyoshi Tanimoto

  4. Dept. of Biochem., Queen’s University Kingston, Canada

    T. Geoffrey Flynn

Authors
  1. Chihiro Nishimura
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  2. Yoshiharu Matsuura
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  3. Tsuyoshi Tanimoto
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  4. Takashi Yamaoka
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  5. Tai Akera
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  6. T. Geoffrey Flynn
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Editor information

Editors and Affiliations

  1. Department of Biochemistry, Purdue University, West Lafayette, Indiana, 47907, USA

    Henry Weiner

  2. Chemisches Zentrallabor, Inselspital, Bern, CH 3010, Switzerland

    Bendicht Wermuth

  3. Indiana University School of Medicine and Veterans Administration Medical Center, Indianapolis, Indiana, 46202, USA

    David W. Crabb

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© 1990 Plenum Press, New York

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Nishimura, C., Matsuura, Y., Tanimoto, T., Yamaoka, T., Akera, T., Flynn, T.G. (1990). cDNA Cloning and Expression of Human Aldose Reductase. In: Weiner, H., Wermuth, B., Crabb, D.W. (eds) Enzymology and Molecular Biology of Carbonyl Metabolism 3. Advances in Experimental Medicine and Biology, vol 284. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-5901-2_15

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  • DOI: https://doi.org/10.1007/978-1-4684-5901-2_15

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4684-5903-6

  • Online ISBN: 978-1-4684-5901-2

  • eBook Packages: Springer Book Archive

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