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Scrapie

Unconventional Infectious Agent

  • Chapter
Neuropathogenic Viruses and Immunity

Part of the book series: Infectious Agents and Pathogenesis ((IAPA))

Abstract

In 1954, Bjorn Sigurdsson, an Icelandic virologist, summed up a series of experiments that he had been conducting on a number of diseases of sheep, including visna and scrapie.l In comparing his results with those obtained in the burgeoning field of virology, Sigurdsson proposed a new category of infectious diseases, slow infections. He proposed three criteria for slow infections: (1) a very long incubation period lasting from several months to many years; (2) a regular, progressive, and protracted course after the appearance of clinical signs that almost invariably ends in death; and (3) limitation of infection to a single host species and histopathological changes to a single organ or tissue system. Sigurdsson correctly predicted that the third criterion would not stand the test of time, and results on this are detailed later.

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  1. New York State Institute for Basic Research in Developmental Disabilities, Staten Island, New York, 10314, USA

    Richard I. Carp

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  1. Department of Microbiology and Immunology, University of South Florida, College of Medicine, 33612-4799, Tampa, Florida, USA

    Steven Specter  & Herman Friedman  & 

  2. Department of Biomedicine, University of Pisa, I-56127, Pisa, Italy

    Mauro Bendinelli

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Carp, R.I. (1992). Scrapie. In: Specter, S., Bendinelli, M., Friedman, H. (eds) Neuropathogenic Viruses and Immunity. Infectious Agents and Pathogenesis. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-5886-2_7

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