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Neurotropic Retroviruses of Mice, Cats, Macaques, and Humans

  • Chapter
Neuropathogenic Viruses and Immunity

Part of the book series: Infectious Agents and Pathogenesis ((IAPA))

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Abstract

The prominent neurological manifestations associated with infection by the human immunodeficiency virus (HIV) and the human T-lymphotropic retrovirus (HTLV) have focused attention on the neurotropic properties of the family Retroviridae. This family is divided into three subfamilies, the oncoviruses, the lentiviruses, and the spumaviruses, each of which is known to infect the central nervous system (CNS) of their natural animal hosts.1 The only known naturally occurring neurological disease caused by an oncovirus in animals is the spongiform polioencephalomyelopathy caused by murine leukemia virus (MuLV) discovered in the early 1970s in a population of wild mice in southern California (for review, see Gardner2). Since then, several strains of laboratory-derived, temperature-sensitive, and mutant MuLV have produced a similar disease experimentally in mice and rats.3,4

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Author notes

  1. Andrew Lackner

    Present address: New Mexico Regional Primate Research Laboratory, New Mexico State University,Holloman Air Force Base, New Mexico, 88330-1027, USA

Authors and Affiliations

  1. Department of Pathology, School of Medicine, University of California, Davis, California, 95616, USA

    Murray Gardner

  2. California Primate Research Center, University of California, Davis, California, 95616, USA

    Andrew Lackner & Linda Lowenstine

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  1. Murray Gardner
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  2. Andrew Lackner
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  3. Linda Lowenstine
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Editors and Affiliations

  1. Department of Microbiology and Immunology, University of South Florida, College of Medicine, 33612-4799, Tampa, Florida, USA

    Steven Specter  & Herman Friedman  & 

  2. Department of Biomedicine, University of Pisa, I-56127, Pisa, Italy

    Mauro Bendinelli

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© 1992 Plenum Press, New York

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Gardner, M., Lackner, A., Lowenstine, L. (1992). Neurotropic Retroviruses of Mice, Cats, Macaques, and Humans. In: Specter, S., Bendinelli, M., Friedman, H. (eds) Neuropathogenic Viruses and Immunity. Infectious Agents and Pathogenesis. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-5886-2_6

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  • DOI: https://doi.org/10.1007/978-1-4684-5886-2_6

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4684-5888-6

  • Online ISBN: 978-1-4684-5886-2

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