Abstract
Cysteine S-conjugates are formed as a result of enzymatic conjugation of xenobiotics with the tripeptide glutathione and subsequent peptidase cleavage. Enzymatic N-acetylation of cysteine S-conjugates yields the corresponding mercapturic acids, which are excreted in the urine. Thus glutathione and cysteine S-conjugate formation are associated with detoxication and excretion of xenobiotics. However, cysteine S-conjugate β-lyase, which is identical to glutamine transaminase K, catalyzes β-elimination reactions of cysteine S-conjugates, yielding a thiolate, pyruvate, and ammonia.
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Anders, M. W. (1988). Glutathione-dependent toxicity: Biosynthesis and bioactivation of cytotoxic S-conjugates. ISI Atlas of Science: Pharmacology 2, 99-104.
Commandeur, J. N. M., De Kanter, F. J. J., and Vermeulen, N. P. E. (1989). Bioactivation of the cysteine S-conjugate and mercapturic acid of tetrafluoroethylene to acylating reactive intermediates in the rat: Dependence of activation and deactivation activities on acetyl coenzyme A availability. Mol. Pharm. 36, 654 - 663.
Dekant, W., Lash, L. H., and Anders, M. W. (1987). Bioactivation mechanism of the cytotoxic and nephrotoxic S-conjugate S-(2-chloro-1,1,2-trifluoroethyl)-Lcysteine. Proc. Natl. Acad. Sci. USA 84, 7443 - 7447.
Sun, J. D., and Dent, J. G. (1980). A new method for measuring covalent binding of chemicals to cellular macromolecules. Chem.-Biol. Interact. 32, 41 - 61.
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© 1991 Plenum Press, New York
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Harris, J.W., Anders, M.W. (1991). The Use of 19F NMR in the Study of Protein Alkylation by Fluorinated Reactive Intermediates. In: Witmer, C.M., Snyder, R.R., Jollow, D.J., Kalf, G.F., Kocsis, J.J., Sipes, I.G. (eds) Biological Reactive Intermediates IV. Advances in Experimental Medicine and Biology, vol 283. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-5877-0_96
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DOI: https://doi.org/10.1007/978-1-4684-5877-0_96
Publisher Name: Springer, Boston, MA
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