Abstract
There is ample evidence to show that the demonstration of adducts to hemoglobin and other proteins of electrophilically reactive compounds or biological reactive intermediates (BRI) is a relevant indication of the formation of the corresponding DNA adducts, and also that the rates of formation of protein- and DNA adducts are proportional. Measurement of hemoglobin and DNA adducts are therefore complementary. The former has so far been used mainly in the monitoring of lowmol.wt alkylators and BRI whereas DNA adduct monitoring has been applicable mostly to bulky compounds.
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© 1991 Plenum Press, New York
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Ehrenberg, L., Tornqvist, M. (1991). Human Health Risk Assessment and Biological Reactive Intermediates: Hemoglobin Binding. In: Witmer, C.M., Snyder, R.R., Jollow, D.J., Kalf, G.F., Kocsis, J.J., Sipes, I.G. (eds) Biological Reactive Intermediates IV. Advances in Experimental Medicine and Biology, vol 283. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-5877-0_80
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DOI: https://doi.org/10.1007/978-1-4684-5877-0_80
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