Abstract
In polymorphonuclear leukocytes (PMN) arachidonic acid is converted both to (5S)-5-hydroperoxy-(E,Z,Z,Z)-6,8,11,14-eicosatetraenoic acid (5-HPETE) and to (5S,6S)-5(6)-oxido-(E,E,Z,Z)-7,9,11,14-eicosatetraenoic acid (leukotriene A4, LTA4) by the action of 5-lipoxygenase. Furthermore, the specific dioxygenation product 5- HPETE is rapidly metabolized into (5S)-5-hydroxy-(E,Z,Z,Z)-6,8,11,14-eieosatetraenoic acid (5-HETE), presumably by the action of a peroxidase on 5-HPETE. In a further enzymatic step, LTA4 is hydrolysed to give (5S,12R)-5,12-dihydroxy-(Z,E,E,Z)- 6,8,10,14-eicosatetraenoic acid (leukotriene B4, LTB4), which acts as a potent chemoattractant and thus causes further accumulation of circulating PMN (Samuelsson et al., 1987).
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© 1991 Plenum Press, New York
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Ullrich, V., Schatz, M., Meisch, F. (1991). Physiological and Toxicological Roles of Hydroperoxides. In: Witmer, C.M., Snyder, R.R., Jollow, D.J., Kalf, G.F., Kocsis, J.J., Sipes, I.G. (eds) Biological Reactive Intermediates IV. Advances in Experimental Medicine and Biology, vol 283. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-5877-0_8
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DOI: https://doi.org/10.1007/978-1-4684-5877-0_8
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