Abstract
In this paper we explore some of the insights into the mechanisms of human carcinogenesis and into the assessment of cancer risk that could be obtained by the study of individuals at risk of development of a second cancer due to treatment with chemotherapeutic agents. We urge a concerted effort to study the processes by which cancer chemotherapeutic agents result in the production of a second cancer.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Aksoy, M. (1989). Hematotoxicity and carcinogenicity of benzene. Env. Health Perspectives 82, 193–197.
Blayney, D.W., Longo, D.L., Young R.C., Greene, M.H., Hubbard, S.M., Postal, M.G., Duffey, P.L. and Devita, JR., V.T. (1987). Decreasing risk of leukemia with prolonged follow-up after chemotherapy and radiotherapy for Hodgkin’s disease. NEJM 316, 710–714.
Brill, B., Tomonaga, M. and Heyssel, R.M. (1962). Leukemia in man following exposure to ionizing radiation. Ann. Intern. Med. 56, 590–609.
Calabresi, P. and Parks Jr., R.E. (1985). Antiproliferative agents and drugs used for immunosuppression. In Goodman and Gilman’s The Pharmacological Basis of Therapeutics ( L.S. Goodman, T.W. Rall and F. Murad, Eds.). pp. 1247–1306. MacMillan Publishing Company, New York.
Coleman, C.N., Kaplan, H.S., Cox, R., Varghese, A., Butterfield, P. and Rosenberg, S.A. (1982). Leukemias, non-Hodgkin’s lymphomas and solid tumors in patients treated for Hodgkin’s disease. Cancer Surv. 3, 734–744.
Colvin, M. (1982). The alkylating agents. In Pharmacologic Principles of Cancer Treatment ( B.A. Chabner, Ed.). pp. 276–308. W.B. Saunders Co., Philadelphia.
Goldstein, B.D. (1989a). Occam’s razor is dull. Environ. Health Perspectives 82, 199–206.
Goldstein, B.D. (1989b). Clinical hematotoxicity of benzene. In Benzene: Occupational and Environmental Hazards-Scientific Update ( M.A. Mehlman, Ed.). pp. 55–65. Princeton Scientific Publishing Co., Inc., Princeton, NJ.
Hoover, R. (1977). Effects of drugs: Immunosuppression. In Origins of Human Cancer (H.H. Hiatt, J.D. Wetson and J.A. Winsten, Eds.). pp. 369–379. Cold Spring Harbor Conferences on Cell Proliferation 4, Cold Spring Harbor, NY.
Kaldor, J.M., Day, N.E., Pettersson, F., Clarke, E.A., et al. (1990a). Leukemia following chemotherapy for ovarian cancer. NEJM 322, 1–6.
Kaldor, J.M., Day, N.E., Clarke, E.A., Van Leeuwen, F.E., et al. (1990b). Leukemia following Hodgkin’s disease. NEJM 322, 7–13.
Kleinerman, R.A., Curtis, R.E., Boice Jr., J.D., Flannery, J.T. and Fraumeni Jr., J.F. (1982). Second cancers following radiotherapy for cervical cancer. J. Natl. Cancer Inst. 69, 1027–1033.
Kohn, H.I. and Fry, R.J. (1984). Radiation carcinogenesis. NEJM 310, 504–511.
Linet, M.S. (1985). The leukemias: Epidemiologic Aspects. In Monographs in Epidemiology and Biostatistics, Volume 6, Oxford University Press, New York.
Loescher, L.J., Welch-McCaffrey, D., Leigh, S.A., Hoffman, B. and Meyskens, F.L. (1989). Surviving adult cancers. Part 1: Physiologic effects. Annals of Internal Medicine 111, 411–432.
Ludlum, D.B. and Tong, W.P. (1985). DNA modification by the nitrosoureas: Chemical nature and cellular repair. In Cancer Chemotherapy, Vol. II ( E.M. Muggia and M. Nishoff, Eds.). pp. 141–154. Martinus Nijhoff, Boston.
Ludlum, D.B., Colinas, R.J., Kirk, M.C. and Mehta, J.R. (1988). Reaction of reduced metronidazole with guanosine to form an unstable adduct. Carcinogenesis 9, 593–596.
Moolgavkar, S.H., Dewanji, A. and Luebeck, G. (1989). Cigarette smoking and lung cancer: Reanalysis of the British Doctor’s Data. J. Natl. Cancer Inst. 81, 415–420.
National Academy of Sciences (1989). Biologic Markers in Reproductive Toxicology. National Academy Press, Washington D.C.
Pedersen-Bjergaard J., Specht, L., Larsen, S.O. and Ersboll J. (1987). Risk of therapy-related leukaemia and preleukaemia after Hodgkin’s diseases. Relation to age, cumulative dose of alkylating agents, and time from chemotherapy. Lancet 2, 83–88.
Penn, I. (1981). Second malignancies following radiotherapy or chemotherapy for cancer. In The Immunopharmacologic Effects of Radiation Therapy ( B. Serrou, C. Rosenfeld and J.B. Dubois, Eds.). pp. 415–437. Raven Press, New York.
Pui, C-H., Behm, F.G., Raimondi, S.C., Dodge, R.K., George, S.L., Rivera, G.K., Mirro, J., Kalwinsky, D.K., Dahl, G.V., Murphy, S.B., Crist, W.M. and Williams, D.L. (1989). Secondary acute myeloid leukemia in children treated for acute lymphoid leukemia. NEJM 321, 136–142.
Sangeetha, P., Das, U.N., Koratkar, R. and Suryaprabha, P. (1990). Increase in free radical generation and lipid peroxidation following chemotherapy in patients with cancer. Free Radical Biol. & Med. 8, 15–19.
Selikoff, I.J., Hammond, E.L. and Seidman, H. (1979). Mortality experience of insulation workers in the USA and Canada 1943–1976. Ann. NY Acad. Sci. 330, 91–116.
Tucker, M.A., Coleman, C.N., Cox, R.S., Varghese, A. and Rosenberg, S.A. (1988). Risk of second cancers after treatment for Hodgkin’s disease. NEJM 318, 76–81.
Vogelstein B., et al. (1989). Genetic alterations accumulate during colorectal tumorigenesis. In Recessive Oncogenes and Tumor Suppression ( W. Cavenee, N. Hastle, E. Stanbridge, Eds.). Cold Spring Harbor Laboratory, Cold Spring Harbor, NY.
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1991 Plenum Press, New York
About this chapter
Cite this chapter
Goldstein, B.D. (1991). Lessons on the Second Cancers Resulting from Cancer Chemotherapy. In: Witmer, C.M., Snyder, R.R., Jollow, D.J., Kalf, G.F., Kocsis, J.J., Sipes, I.G. (eds) Biological Reactive Intermediates IV. Advances in Experimental Medicine and Biology, vol 283. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-5877-0_78
Download citation
DOI: https://doi.org/10.1007/978-1-4684-5877-0_78
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4684-5879-4
Online ISBN: 978-1-4684-5877-0
eBook Packages: Springer Book Archive