Abstract
Reactive oxygen species have been in focus for some time now, and there are several reviews on this topic. since our contribution to Biological Reactive Intermediates III (Wefers and Sies, 1986), work from our laboratory has been presented comprehensively (Sies, 1986, 1988; Ishikawa and Sies, 1989). Further, the biochemistry of oxygen toxicity has been presented (Cadenas, 1989).
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References
Ames, B.N. (1983). Dietary carcinogens and anticarcinogens. Science 221, 1256–1264.
Aubry, J.M. (1985). Search for singlet oxygen in the decomposition of hydrogen peroxide by mineral compounds in aqueous solutions. J. Am. Chem. Soc. 103 7218–7224.
Burton, G.W. and IngoId, K.U. (1984). D-Carotene: An unusual type of lipid antioxidant. Science 224, 569–573.
Cadenas, E. (1989). Biochemistry of oxygen toxicity. Annu. Rev. Biochem. 58, 79–110.
Cadet, J., Decarroz, C., Wang, S.Y. and Midden, W.R. (1983). Mechanisms and products of photosensitised degradation of nucleic acids and related model compounds. Iss. J. Cehm. 23, 420–429.
Cavina, G., Gallinella, B., Porra, R., Pecora, P. and Saraci, C. (1988). Carotenoids, retinoids and alpha-tocopherol in human serum–identification and determination by reversed-phase HPLC. J. Pharm. Biomed. Anal. 6, 259–269.
Cerutti, P.A. (1985). Prooxidant state and tumour promotion. Science 221, 1256–1264.
Devasagayam, T.P.A., Di Mascio, P., Kaiser, S. and Sies, H. (1990). Activity of thiols as singlet molecular oxygen quenchers. J. Photochem. Photobiol. (submitted).
Di Mascio, P. and Sies, H. (1989). Quantification of singlet oxygen generated by thermolysis of 3,3’-(1,4-naphthylidene) dipropionate. Monomol and dimol photoemission and the effects of 1,4-diazabicyclo (2.2.2) octane. J. Am. Chem. Soc. 111, 2909–2914.
Di Mascio, P., Wefers, H., Do-Thi, H-P., Lafleur, M.V.M. and Sies, H. (1989a). Singlet molecular oxygen causes loss of biological activity in plasmid and bacteriophage DNA and induces single-strand breaks. Biochim. Biophys. Acta 1007, 151–157.
Di Mascio, P., Kaiser, S. and Sies, H. (1989b). Lycopene as the most efficient biological carotenoid singlet oxygen quencher. Arch. Biochem. Biophys. 274, 532–538.
Di Mascio, P., Mench, C.F.M., Nigro, R.G., Sarasin, A. and Sies, H. (1990). Singlet molecular oxygen induced mutagenicity in a mammalain SV40-based shuttle vector. Photochem. Photobiol.
Epe, B., Miltzel, P. and Adam, W. (1988). DNA damage by oxygen radicals and excited state species: A comparative study using enzymatic probes in vitro. Chem. Biol. Interact. 67, 149–165.
Epe, B., Hegler, J. and Wild, D. (1989). Singlet oxygen as the ultimately reactive species in Salmonella typhimurium DNA damage induced by methylene blue/visible light. Carcinogenesis 10, 2019–2024.
Esterbauer, H., Striegl, G., Puhl, H. and Rotheneder, M. (1989). Continuous monitoring of in vitro oxidation of human low density lipoprotein. Free Rad. Res. Commun. 6, 67–75.
Foote, C.S. and Denny, r.W. (1968). Chemistry of singlet oxygen VIII. Quenching by 13- crotene. J. Am. Chem. Soc. 90, 6233–6235.
Gey, K.F., Brubacher, G.B. and Stähelin, H.B. (1987). Plasma levels of antioxidant vitamins in relation to ischemic heart disease and cancer. Am. J. Clin. Nutr. 45, 1368–1377.
Handelman, G.J., Dratz, E.A., Reay, C.C. and van Kuijk, F.J.G.M. (1988). Carotenoids in the human macula and whole retina. Invest. Ophthamol. Vis. Sci. 29, 850–855.
Ishikawa, T. and Sies, H. (1989). Glutathione as an antioxidant: Toxicological aspects. In Glutathione: Chemical, Biochemical and Medical Aspects, Part B. (D. Dolphin, R. Poulson and D. Avramovic, Eds. ) pp. 86–109.
Kaiser, S., Di Mascio, P. and Sies, H. (1989). Lipoat and Singulettsauerstoff. In Thioctsdure (H.O. Borbe and H. Ulrich, Eds.) pp. 69–76, pmi Verlag GmbH, Frankfurt.
Kaiser, S., Di Mascio, P., Murphy, M.E. and Sies, H. (1990). Physical and chemical scavenging of singlet oxygen by tocopherols. Arch. Biochem. Biophys. 276, XXX-XXX.
Krinsky, N.I. (1990). antioxidant functions of carotenoids. Free Rad. Biol. Med. 7 XXX-XXX.
Mathews-Roth, M.M. (1985). Carotenoids and cancer prevention-experimental and epidemiological studes. Pure Appl. Chem., 57, 717–722.
Meier, B., Radeke, H.H., Selle, S., Younes, M., Sies, H., Resch, K. and Habermehl, G.G. (1989). Human fibroblasts release reactive xoygen species in response to interleukin-1 or tumour necrosis factor-alpha. Biochem. J. 263, 539–545.
Midden, W.R. and Wang, S.Y. (1983). Singlet oxygen generation for solution kinetics: clean and simple. J. Am. Chem. Soc. 105, 4129–4135.
Murphy, M.E. and Sies, H. (1990). Visible-range low-level chemiluminescence in biological systems. Meth. Enzymol. (in press).
Packer, J.E., Mahood, J.S., Mora-Arellano, O., Slater, T.F., Wilson, R.L. and Wolfenden, B.S. (1981). Free radical and singlet oxygen scavengers. Reaction of a peroxy-radical with betacarotene, diphenyl furan and 1,4-diazabicyclo (2.2.2)- octane. Biochem. Biophys. Res. Commun. 98, 901–906.
Peto, R., Doll, R., Buckley, J.D. and Sporn, M.B. (1981). Can dietary beta-carotene materially reduce human cancer rates? Nature (London) 290, 201–208.
Pryor, W.A. (1986). Oxy-radicals and related species: Their formation, lifetimes, and ractions. Annu. Rev. Physiol. 48, 657–667.
Saito, I., Matsuura, T. and Inoue, K. (1983). Formation of superoxide ion via one-electron transfer from electron donors to singlet oxygen. J. Am. Chem. Soc. 105, 3200–3206.
Saito, I., Nagata, R., Nakagawa, H., Moriyama, H., Matsuura, T. and Inoue, K. (1987). New singlet oxygen source and trapping reagent for peroxide intermediates. Free Rad. Res. Commun. 2, 327–336.
Sies, H. (1986). Biochemistry of oxidative stress. Angew. Chem. (Int. Ed. Engl.) 25, 1058–1071.
Sies, H. (1988). Oxidative stress: Quinone redox cycling. ISI Atlas of Science: Biochemistry 1, 109–114.
Thompson, J.N., Duval, S. and Verdier, P. (1985). Investigations of carotenoids in human blood using high performance liquid chromatography. J. Micronutr. Anal. 1, 81–91.
Wefers, H. and Sies, H. (1986). Reactive oxygen species formed in vitro and in cells: role of thiols (GSH). Model studies with xanthine and xanthine oxidase and horseradish peroxidase. In Biological Reactive Intermediates III (J.J. Wefers, H. and Sies, H, Eds.) pp. 505–512, Plenum Publishing Corporation.
Wefers, H., Schulte-Frohlinde, D. and Sies, H. (1987). Loss of transforming activity of plasmid DNA (pBR322). In E. coli caused by singlet molecular oxygen. FEBS Lett. 211, 49–52.
Ziegler, R.G. (1989). A review of epidemiologic evidence that carotenoids reduce the risk of cancer. J. Nutr. 119, 116–122.
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© 1991 Plenum Press, New York
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Di Mascio, P., Kaiser, S.P., Devasagayam, T.P.A., Sies, H. (1991). Biological Significance of Active Oxygen Species: In Vitro Studies on Singlet Oxygen-Induced DNA Damage and on the Singlet Oxygen Quenching Ability of Carotenoids, Tocopherols and Thiols. In: Witmer, C.M., Snyder, R.R., Jollow, D.J., Kalf, G.F., Kocsis, J.J., Sipes, I.G. (eds) Biological Reactive Intermediates IV. Advances in Experimental Medicine and Biology, vol 283. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-5877-0_7
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DOI: https://doi.org/10.1007/978-1-4684-5877-0_7
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