Abstract
Most chemcicals formed in our environment require metabolic activation to exert their deleterious effects in target cells. The major activation pathway is oxidative metabolism mainly catalyzed by cytochrome P-450 (P-450)-dependent monooxygenase systems which have been resolved into at least two catalytic components, namely a species of P-450 and NADPH-cytochrome c (P-450) reductase. Furthermore, multiple forms of P-450 have been isolated and purified from some species of experimental animals including Syrian golden hamster and from human (Watanabe, M. et al., 1987; Guengerich, F.P. 1987; Mizokami, K. et al., (1983).
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Abbreviations
- P-450:
-
Cytochrome P-450
- BPbenzo[a]pyrene:
-
benzo[a]pyrene
- MC:
-
3-methylcholanthrene
References
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© 1991 Plenum Press, New York
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Fujii, H., Sagami, I., Ohmachi, T., Kikuchi, H., Watanabe, M. (1991). Tissue Difference in Expression of Cytochrome P-450 between Liver and Lung of Syrian Golden Hamsters Treated with 3- Methylcholanthrene. In: Witmer, C.M., Snyder, R.R., Jollow, D.J., Kalf, G.F., Kocsis, J.J., Sipes, I.G. (eds) Biological Reactive Intermediates IV. Advances in Experimental Medicine and Biology, vol 283. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-5877-0_56
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DOI: https://doi.org/10.1007/978-1-4684-5877-0_56
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