Abstract
Benzene, is hematotoxic and leukemogenic in humans (Aksoy, M., 1987). It is widely accepted that benzene requires metabolic activation to exert its toxic and carcinogenic effects (Cooper, K.R. and Snyder, R. 1987). The majority of benzene metabolism occurs in liver with phenol (PH), hydroquinone (HQ) and catechol (CAT) being the major metabolites formed. Benzene is also oxidized to a ring-opened product trans, trans-muconic acid.
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© 1991 Plenum Press, New York
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Subrahmanyam, V.V., Kolachana, P., Smith, M.T. (1991). Effect of Phenol and Catechol on the Kinetics of Human Myeloperoxidase-Dependent Hydroquinone Metabolism. In: Witmer, C.M., Snyder, R.R., Jollow, D.J., Kalf, G.F., Kocsis, J.J., Sipes, I.G. (eds) Biological Reactive Intermediates IV. Advances in Experimental Medicine and Biology, vol 283. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-5877-0_50
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DOI: https://doi.org/10.1007/978-1-4684-5877-0_50
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