Abstract
Primaquine,6-methoxy-8-(4-amino-l-methylbutylamino)quinoline, is one of the most effective antimarial agents but because of its low therapeutic index its use is limited. Unlike the 4-aminoquinolines it is believed to act on the liver schizont stage and not the erythrocyte stage of the parasites life cycle. However the drug is reported to cause hemolytic anemia, especially in individuals whose erythrocytes are deficient in glucose-6-phosphate dehydrogenase (Beutler, 1969). In erythrocytes, primaquine or its liver metabolite 5-OH-primaquine is reported to cause intraerythrocytic superoxide and hydrogen peroxide formation, methemoglobinemia, the formation of Heinz bodies, and occasionally the induction of hemolysis (Cohen and Hochstein, 1964; Summerfield and Tudhope, 1978).
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Abbreviations
- GSH:
-
reduced glutathione
- GSSG:
-
oxidised glutathione
- Hepes:
-
4-(2- hydroxyethyl)-1-piperazine-ethane-sulphonic acid
- HPLC:
-
high performance liquid chromatography
- DETAPAC:
-
Diethylenetriamine penta-acetic acid
- H2O2 :
-
hydrogen peroxide.
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© 1991 Plenum Press, New York
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Silva, J.M., O’Brien, P.J. (1991). Primaquine-Induced Oxidative Stress in Isolated Hepatocytes as a Result of Reductive Activation. In: Witmer, C.M., Snyder, R.R., Jollow, D.J., Kalf, G.F., Kocsis, J.J., Sipes, I.G. (eds) Biological Reactive Intermediates IV. Advances in Experimental Medicine and Biology, vol 283. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-5877-0_47
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DOI: https://doi.org/10.1007/978-1-4684-5877-0_47
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