Abstract
Diethylstilbestrol (DES), a synthetic estrogen, has increasingly been associated with human cancer (IARC 1979). Over the years, DES has been shown to induce tumors in reproductive- and various other organs in animals (IARC 1979). The exact mechanism of estrogen-induced carcinogenesis is not understood. A role of reactive metabolites in estrogen-induced carcinogenesis has been postulated (Metzler, 1987), because hormonal potency could not be correlated with tumor incidence.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
Similar content being viewed by others
References
Bradford, M.M. (1976). A rapid and sensitive method for the quantification of microgram quantities of protein utilizing the principles of protein-dye-binding. Anal. Biochem. 72, 248–254.
Dignam, J.D. and Strobel, H.W. (1977). NADPH-cytochrome P-450 reductase from rat liver: Purification by affinity chromatography and characterization. Biochemistry 16, 1116–1122.
Grownow, M. (1980). Nuclear proteins and chemical carcinogenesis. Chem. Biol. interact. 29, 1–30.
van Holde, K.E. (1989). Chromatin structure and transcription. In: Chromatin, Alexender Rich ed. Dpringer Verlag, New York, pp 355–408.
IARC (1979). The evaluation of the carcinogenic risk of chemicals to hormone: Sex hormone. IARC Monographs, 21, 173–221.
Kalyanaraman, B., SeaIly, R., and Liehr, J.G. (1989). Characterization of semiquinone free radicals formed from Astilbene catechol estrogens: an ESR spin stabilization and spin trapping study. J. Biol. Chem. 264, 11014–11019.
Liehr, J.G., Roy, D., and Gladek, A. (1989). Mechanism of inhibition of renal carcinogenesis in male Syrian hamsters by vitamin C. Carcinogenesis 10, 1983–1988.
Metzler, M (1987). Metabolic activation of xenobiotic stilbene estrogens. Fed. Proc. 46, 1855–1857.
Pezzuto, J.M., Lea, M.A., and Yang, C.S. (1976). Binding of metabolically activated benzopyrene to nuclear macromolecules. Cancer Res. 36, 3647–3653.
Roy, D. and Liehr, J.G. (1989). Metabolic activation of diethylstilbestrol to diethylstilbestrol-4’4“-quinone in Syrian hamsters. Carcinogenesis 10, 1241–1245, 1989.
Roy, D. and Snodgrass, W.R. (1990). Covalent binding of phenytoin to protein and modulation of phenytoin metabolism by thiols in A/J mouse liver microsome. J. Pharmacol. Exp. Ther., In Press.
Yu, F. (1975). An improved method for the quantitative isolation of rat liver nuclear polymerase. Biochim. Biophys. Acta. 395, 329–336.
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1991 Plenum Press, New York
About this chapter
Cite this chapter
Roy, D. (1991). Reactive Potential of Diethylstilbestrol Reactive Metabolites Towards Cellular Nuclear Proteins: Implications for Estrogen*Induced Carcinogenesis. In: Witmer, C.M., Snyder, R.R., Jollow, D.J., Kalf, G.F., Kocsis, J.J., Sipes, I.G. (eds) Biological Reactive Intermediates IV. Advances in Experimental Medicine and Biology, vol 283. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-5877-0_111
Download citation
DOI: https://doi.org/10.1007/978-1-4684-5877-0_111
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4684-5879-4
Online ISBN: 978-1-4684-5877-0
eBook Packages: Springer Book Archive