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Clinical Serological and Intestinal Immune Responses to Rotavirus Infection of Humans

  • Chapter
Medical Virology 9

Abstract

Rotaviruses are one of the most common infectious agents with the potential to cause disease in humans that are encountered during the normal life span. Infections of the intestinal tract have been documented in newborn babies, in young children, in adults and in the elderly (Bishop, 1986; Hjelt, 1988; Hrdy, 1987; Steinhoff, 1980). The clinical consequences of infection differ in different age-groups (Rodriguez et al. 1987).

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References

  • Abe Y, Inouye S (1979) Complement-fixing immunoglobulin M antibody response in patients with infantile gastroenteritis. J Clin Microbiol 9:284–286.

    PubMed  CAS  Google Scholar 

  • Adams WR, Kraft LM (1967) Electron microscopic study of the intestinal epithelium of mice infected with the agent of epizootic diarrhoea of infant mice (EDIM) virus. Am J Pathol 51: 39–60.

    PubMed  CAS  Google Scholar 

  • Angeretti A, Magi MT, Merlino C, Ferrara B, Ponzi AN (1987) Specific serum IgA in rotavirus gastroenteritis. J Med Virol 23:345–349.

    Article  PubMed  CAS  Google Scholar 

  • Barnes GL, Hewson PH, McLellan JA, Doyle LW, Knoches AML, Kitchen WH, Bishop RF (1982) A randomized trial of oral gammaglobulin in low-birth-weight infants infected with rotavirus. Lancet 11:1371–1373.

    Article  Google Scholar 

  • Bartlett III AV, Reves RR, Pickering LK (1988) Rotavirus in infant-toddler day care centers: Epidemiology relevant to disease control strategies. J Paediatr 113:435–441.

    Article  Google Scholar 

  • Beards GM, Desselberger V (1989) Determination of rotavirus serotype-specific antibodies in sera by competitive enhanced enzyme immunoassay. J Virol Methods 24:103–110.

    Article  PubMed  CAS  Google Scholar 

  • Bell LM, Clarke HF, Offit PA, Horton Slight P, Arbeter AM, Plotkin SA (1988) Rotavirus serotype-specific neutralizing activity in human milk. Am J Dis Child 142:275–278.

    PubMed  CAS  Google Scholar 

  • Berger R, Hadjiselimovic F, Just M, Reigel P (1983) Effect of feeding human milk on nosocomial infections in an infants ward. Develop biol Standard 53:219–228.

    CAS  Google Scholar 

  • Bernstein DI, Ziegler JM, Ward RL (1986) Rotavirus fecal IgA antibody response in adults challenged with human rotavirus. J Med Virol 20:297–304.

    Article  PubMed  CAS  Google Scholar 

  • Bernstein DI, McNeal MM, Schiff GM, Ward RL (1989) Induction and persistence of local rotavirus antibodies in relation to serum antibodies. J Med Virol 28:90–95.

    Article  PubMed  CAS  Google Scholar 

  • Bishop RF (1986) Epidemiology of diarrhoeal disease caused by rotavirus. In Holmgren J, Lindberg A, Mollby R (ed.) Development of vaccines and drugs against diarrhoea. Stockholm: Studentlitteratur, pp 158–170.

    Google Scholar 

  • Bishop RF (1988) The present status of rotavirus vaccine development. Southeast Asian J Trop Med Pub Hlth 19:429–435.

    CAS  Google Scholar 

  • Bishop RF, Barnes GL, Cipriani E, Lund JS (1983) Clinical immunity after neonatal rotavirus infection. A prospective longitudinal study in young children. N Engl J Med 309:72–76.

    Article  PubMed  CAS  Google Scholar 

  • Bishop RF, Davidson GP, Holmes IH, Ruck BJ (1973) Virus particles in the epithelial cells of duodenal mucosa from children with acute non-bacterial gastroenteritis. Lancet ii:1281–1283.

    Article  Google Scholar 

  • Black RE, Merson MH, Rahman ASMM, Yunus M, Alim ARMA, Huq I, Yolken RH, Curlin GT (1980) A two year study of bacterial, viral and parasitic agents associated with diarrhea in rural Bangladesh. J Infect Dis 142:660–664.

    Article  PubMed  CAS  Google Scholar 

  • Black RE, Merson MH, Huq I, Alim ARA, Yunus MD (1981) Incidence and severity of rotavirus and Escherichia coli diarrhoea in rural Bangladesh. Implications for vaccine development. Lancet i:141–143.

    Article  Google Scholar 

  • Black RE, Brown KH, Becker S, Yunus M (1982a) Longitudinal studies of infectious diseases and physical growth of children in rural Bangladesh II Incidence of diarrhea and association with known pathogens. Am J Epidemiol 115:315–324.

    PubMed  CAS  Google Scholar 

  • Black RE, Greenberg HB, Kapikian AZ, Brown KH, Becker S (1982b) Acquisition of serum antibody to Norwalk virus and rotavirus and relation to diarrhea in a longitudinal study of young children in rural Bangladesh. J Infect Dis 145:483–489.

    Article  PubMed  CAS  Google Scholar 

  • Brussow H, Werchau H, Lerner L, Mietens C, Liedtke W, Sidothi J, Sotek J (1988) Seroconversion patterns to four human rotavirus serotypes in hospitalised infants with acute rotavirus gastroenteritis. J Infect Dis 158:588–595.

    Article  PubMed  CAS  Google Scholar 

  • Bryden AS, Thouless MF, Hall CJ, Flewett TH, Wharton BA, Mathew PM, Craig I (1982) Rotavirus infections in a special-care baby unit. J Infect 4:43–48.

    Article  PubMed  CAS  Google Scholar 

  • Buller CR, Moxley RA (1988) Natural infection of porcine ileal dome M cells with rotavirus and enteric adenovirus. Vet Pathol 25:516–517.

    Article  PubMed  CAS  Google Scholar 

  • Cadranel S, Zeglache S, Jonckheer T, Zissis G, Andre FE, Bogaerts H, Delem A (1987) Factors affecting antibody response of newborns to repeated administrations of the rotavirus vaccine RIT4237. J Pediatr Gastroent Nutr 6:525–528.

    Article  CAS  Google Scholar 

  • Cameron DJS, Bishop RF, Veenstra AA, Barnes GL (1978a) Noncultivable viruses and neonatal diarrhea: a fifteen-month survey in a newborn special care nursery. J Clin Microbiol 8:93–98.

    PubMed  CAS  Google Scholar 

  • Cameron DJS, Bishop RF, Veenstra AA, Barnes GL, Holmes IH, Ruck BJ (1978b) Pattern of shedding of two noncultivable viruses in stools of newborn babies. J Med Virol 2:7–13.

    Article  PubMed  CAS  Google Scholar 

  • Chiba S, Nakata S, Urasawa T, Urasawa S, Yokoyama T, Morita Y, Taniguchi K, Nakao T (1986) Protective effect of naturally acquired homotypic and heterotypic rotavirus antibodies. Lancet ii:417–421.

    Article  Google Scholar 

  • Christy C, Madore HP, Pichichero ME, Gala C, Pincus P, Vosefski D, Hoshino T, Kapikian A, Dolin R, Elmwood M, Panorama Paediatric Groups (1988) Field trial of rhesus rotavirus vaccine in infants. Pediatr Infect Dis J 7:645–650.

    Article  PubMed  CAS  Google Scholar 

  • Clark HF, Dolan KT, Horton-Slight P, Palmer J, Plotkin SA (1985) Diverse serologic response to rotavirus infection of infants in a single epidemic. Pediatr Infect Dis 4:626–631.

    Article  PubMed  CAS  Google Scholar 

  • Clark HF, Furukawa T, Bell LM, Offit PA, Perrella PA, Plotkin SA (1986) Immune response of infants and children to low-passage bovine rotavirus (strain WC3). Am J Dis Child 140:350–356.

    PubMed  CAS  Google Scholar 

  • Collins J, Starkey WG, Wallis TS, Clarke GJ, Worton KJ, Spencer AJ, Haddon SJ, Osborne MP, Candy DCA, Stephen J (1988) Intestinal enzyme profiles in normal and rotavirus-infected mice. J Pediatr Gastroent Nutr 7:264–272.

    Article  CAS  Google Scholar 

  • Coulson BS (1987) Variation in neutralization epitopes of human rotaviruses in relation to genomic RNA polymorphism. Virology 159:209–212.

    Article  PubMed  CAS  Google Scholar 

  • Coulson BS, Grimwood K, Bishop RF, Barnes GL (1989) Evaluation of end-point titration, single dilution and capture enzyme immunoassays for measurement of antirotaviral IgA and IgM in infantile secretions and serum. J Virol Methods 26:53–66.

    Article  PubMed  CAS  Google Scholar 

  • Coulson BS, Tursi JM, McAdam WJ, Bishop RF (1986). Derivation of neutralizing monoclonal antibodies to human rotaviruses and evidence that an immunodominant neutralization site is shared between serotypes 1 and 3. Virology 154:302–313.

    Article  PubMed  CAS  Google Scholar 

  • Davidson GP, Barnes GL (1979) Structural and functional abnormalities of the small intestine in infants and young children with rotavirus enteritis. Acta Paediatr Scand 68:181–186.

    Article  PubMed  CAS  Google Scholar 

  • Davidson GP, Bishop RF, Townley RRW, Holmes IH, Ruck BJ (1975) Importance of a new virus in acute sporadic enteritis in children. Lancet i:242–251.

    Article  Google Scholar 

  • Davidson GP, Hogg RJ, Kirubakaran CP (1983) Serum and intestinal immune response to rotavirus enteritis in children. Infect Immun 40:447–452.

    PubMed  CAS  Google Scholar 

  • Delem A, Vesikari T (1987) Detection of serum antibody responses to RIT4237 rotavirus vaccine by ELISA and neutralization assays. J Med Virol 21:231–238.

    Article  PubMed  CAS  Google Scholar 

  • de Zoysa I, Feachem RG (1985) Intervention for the control of diarrhoeal diseases among young children: rotavirus and cholera immunization. Bull WHO 63:569–583.

    PubMed  Google Scholar 

  • Dolan KT, Twist EM, Horton-Slight P, Forrer C, Bell IM, Plotkin SA, Clark HF (1985) Epidemiology of rotavirus electropherotypes determined by a simplified diagnostic technique with RNA analysis. J Clin Microbiol 21:753–758.

    PubMed  CAS  Google Scholar 

  • Duffy LC, Riepenhoff-Talty M, Byers TE, LaScolea LJ, Zielenzny MA Dryja DM, Ogra PL (1986) Modulation of rotavirus enteritis during breast feeding. Implications on alterations in the intestinal bacterial flora. Am J Dis Child 140:1164–1168.

    PubMed  CAS  Google Scholar 

  • Ebina T, Sato A, Umezu K, Ishida N, Ohyama S, Oizumi A, Aikawa K, Katagiri S, Katsushima N, Imai A, Kitaoka S, Suzuki H, Konno T (1985) Prevention of rotavirus infection by oral administration of cow colostrum containing antihumanrotavirus antibody. Med Microbiol Immunol 174:177–185.

    Article  PubMed  CAS  Google Scholar 

  • Edelman R (1987) Perspective on the development and deployment of rotavirus vaccines. Pediatr Inf Dis J 6:704–710.

    Article  CAS  Google Scholar 

  • Eiden J, Losonsky GA, Johnson J, Yolken RH (1985) Rotavirus RNA variation during chronic infection of immunocompromised children. Pediatr Infect Dis 4:632–637.

    Article  PubMed  CAS  Google Scholar 

  • Eiden J, Verleur DG, Vonderfecht SL, Yolken RH (1988) Duration and pattern of asymptomatic rotavirus shedding by hospitalized children. Pediatr Infect Dis 7:564–569.

    CAS  Google Scholar 

  • Estes MK, Palmer EL, Obijeski JF (1983) Rotaviruses: A review. Curr Top Microbiol Immunol 105:123–184.

    Article  PubMed  CAS  Google Scholar 

  • Flores J, Nakagomi O, Nakagomi T, Glass R, Gorziglia M, Askaa J, Hoshino Y, Perez-Schael I, Kapikian AZ (1986). The role of rotaviruses in pediatric diarrhea. Ped Infect Dis 5:553–562.

    Article  Google Scholar 

  • Flores J, Perez-Schael I, Blanco M, Vilar M, Garcia D, Perez M, Daoud N, Midthun K, Kapikian AZ (1989) Reactions to and antigenicity of two human-rhesus rotavirus reassortant vaccine candidates of serotypes 1 and 2 in Venezuelan infants. J Clin Microbiol 27:512–518.

    PubMed  CAS  Google Scholar 

  • Friedman MG, Galil A, Sarov B, Margaleth M, Katzir G, Midthun K, Taniguchi K, Urasawa S, Kapikian AZ, Edelman R, Sarov I (1988) Two sequential outbreaks of rotavirus gastroenteritis: evidence for symptomatic and asymptomatic reinfections. J Infect Dis 158:814–822.

    Article  PubMed  CAS  Google Scholar 

  • Gerna G, Battaglia M, Milenesi G, Passarani N, Percivalle E, Cataneo E (1984) Serotyping of cell culture-adapted subgroup 2 human rotavirus strains by neutralization. Infect Immun 43:722–729.

    PubMed  CAS  Google Scholar 

  • Graham DY, Dufour GR, Estes MK (1987) Minimal infective dose of rotavirus. Arch Virol 92:261–271.

    Article  PubMed  CAS  Google Scholar 

  • Grauballe PC, Hornsleth A, Hjelt K, Krasilnikoff PA (1986) Detection by ELISA of immunoglobulin G subclass-specific antibody responses in rotavirus infections in children. J Med Virol 18:277–281.

    Article  PubMed  CAS  Google Scholar 

  • Grimwood K, Abbott GD, Fergusson DM, Jennings LC, Allen JM. (1983) Spread of rotavirus within families: a community based study. Br Med J 287:575–577.

    Article  CAS  Google Scholar 

  • Grimwood K, Lund JCS, Coulson BS, Hudson IL, Bishop RF, Barnes GL (1988) Comparison of serum and mucosal antibody responses following severe acute rotavirus gastroenteritis in young children. J Clin Microbiol 26:732–738.

    PubMed  CAS  Google Scholar 

  • Gurwith M, Wenman W, Hinde D, Feltham S, Greenberg H (1981) A prospective study of rotavirus infection in infants and young children. J Infect Dis 144:218–224.

    Article  PubMed  CAS  Google Scholar 

  • Gust ID, Pringle RC, Barnes GL, Davidson GP, Bishop RF (1977) Complement-fixing antibody response to rotavirus infection. J Clin Microbiol 5:125–130.

    PubMed  CAS  Google Scholar 

  • Hamilton JR, Gall DG (1982) Pathopysiological and clinical features of viral enteritis. In Tyrrell D, Kapikian AZ (ed) Virus infections of the gastrointestinal tract. New York: Marcel Dekker, pp227–238.

    Google Scholar 

  • Haug KW, Orstavik I, Kvelstad G (1978) Rotavirus infections in families. A clinical and virological study. Scand J Infect Dis 10:265–269.

    PubMed  CAS  Google Scholar 

  • Hilpert H, Brussow H, Mietens C, Sidoti J, Lerner L, Werchau H (1987) Use of bovine milk concentrate containing antibody to rotavirus to treat rotavirus gastroenteritis in infants. J Infect Dis 156:158–166.

    Article  PubMed  CAS  Google Scholar 

  • Hjelt K (1988) Acute rotavirus gastroenteritis in children. Danish Med Bull 35:222–236.

    PubMed  CAS  Google Scholar 

  • Hjelt K, Grauballe PC, Schiotz PO, Andersen L, Krasilnikoff PA (1985) Intestinal and serum immune response to a naturally acquired rotavirus gastroenteritis in children. J Pediatr Gastroent Nutr 4:60–66.

    Article  CAS  Google Scholar 

  • Hjelt K, Grauballe PC, Anderson PO, Howitz P, Krasilnikoff PA (1986) Antibody response in serum and intestine in children up to six months after a naturally acquired rotavirus gastroenteritis. J Pediatr Gastroent Nutr 5:74–80.

    Article  CAS  Google Scholar 

  • Hjelt K, Grauballe PC, Paerregaard A, Nielsen OH, Krasilnikoff PA (1987a) Protective effect of preexisting rotavirus-specific immunoglobulin A against naturally acquired rotavirus infection in children. J Med Virol 21:39–47.

    Article  PubMed  CAS  Google Scholar 

  • Hjelt K, Nielsen OH, Paerregaard A, Grauballe PC, Krasilnikoff PA (1987b) Acute gastroenteritis in children attending day-care centres with special reference to rotavirus infections II Clinical manifestations. Acta Paediatr Scand 76:763–768.

    Article  PubMed  CAS  Google Scholar 

  • Ho M, Glass RI, Pinsky PF, Anderson LJ (1988) Rotavirus as a cause of diarrheal morbidity and mortality in the United States. J Infect Dis 158:1112–1116.

    Article  PubMed  CAS  Google Scholar 

  • Holzel H, Cubitt DW, McSwiggan DA, Sanderson PJ, Church J (1980) An outbreak of rotavirus infection among adults in a cardiology ward. J Infect 2:33–37.

    Article  PubMed  CAS  Google Scholar 

  • Hoshino Y, Wyatt RG, Greenberg HB, Flores J, Kapikian AZ (1984) Serotypic similarity and diversity of rotaviruses of mammalian and avian origin as studied by plaque reduction neutralisation. J Infect Dis 149:694–702.

    Article  PubMed  CAS  Google Scholar 

  • Hoshino Y, Sereno MM, Midthun K, Flores J, Kapikian AZ, Chanock RM (1985) Independent segregation of two antigenic specificities (VP3 and VP7) involved in neutralization of rotavirus infectivity. Proc Natl Acad Sci USA 82:8701–8704.

    Article  PubMed  CAS  Google Scholar 

  • Hoshino Y, Saif LJ, Sereno MM, Chanock RM, Kapikian AZ (1988) Infection immunity of piglets to either VP3 or VP7 outer capsid protein confers resistance to challenge with a virulent rotavirus bearing the corresponding antigen. J Virol 62:744–748.

    PubMed  CAS  Google Scholar 

  • Hrdy DB (1987) Epidemiology of rotaviral infection in adults. Rev Infect Dis 9:461–469.

    Article  PubMed  CAS  Google Scholar 

  • Jayashree S, Bhan MK, Kumar R, Bhandari N, Sazawal S (1988a) Protection against neonatal rotavirus infection by breast milk antibodies and trypsin inhibitors. J Med Virol 26:333–338.

    Article  PubMed  CAS  Google Scholar 

  • Jayashree S, Bhan MK, Kumar R, Raj P, Glass R, Bhandari N (1988b) Serum and salivary antibodies as indicators of rotavirus infection in neonates. J Infect Dis 158:1117–1120.

    Article  PubMed  CAS  Google Scholar 

  • Jayashree S, Bhan MK, Raj P, Kumar R, Svensson L, Stintzing G, Bhandari N (1988c) Neonatal rotavirus infection and its relation to cord blood antibodies. Scand J Infect Dis 20:249–253.

    Article  PubMed  CAS  Google Scholar 

  • Kapikian AZ, Chanock RM (1985) Rotaviruses. In Fields BN, Knipe DM, Chanock RM, Melnick JL, Roizman B, Shope RE (ed.), Virology. New York: Raven Press, pp 863–906.

    Google Scholar 

  • Kapikian AZ, Wyatt RG, Levine MM, Yolken RH, Vankirk DH, Dolin R, Greenberg HB, Chanock RM (1983a) Oral administration of human rotavirus to volunteers: induction of illness and correlates of resistance. J Infect Dis 147:95–106.

    Article  PubMed  CAS  Google Scholar 

  • Kapikian AZ, Wyatt RG, Levine MM, Black RE, Greenberg HB, Flores J, Kalica AR, Hoshino Y, Chanock RM (1983b) Studies in volunteers with human rotaviruses. Devel Biol Stand 53:209–218.

    CAS  Google Scholar 

  • Kapikian AZ, Flores J, Hoshino Y, Glass RI, Midthun K, Gorziglia M, Chanock RM (1986) Rotavirus: the major etiologic agent of severe infantile diarrhoea may be controllable by a “Jennerian” approach to vaccination. J Infect Dis 153: 815–822.

    Article  PubMed  CAS  Google Scholar 

  • Kohl S, Harmon MW, Ping Tang JY (1983) Cytokine-stimulated human killer cytotoxicity: response to rotavirus-infected cells. Pediatr Res 17:868–872.

    Article  PubMed  CAS  Google Scholar 

  • Koopman JS, Turkish VJ, Monto AS, Gouvea V, Srivastava S, Isaacson RE (1984) Patterns and etiology of diarrhoea in three clinical settings. Am J Epidemiol 119:114–123.

    PubMed  CAS  Google Scholar 

  • Linhares AC, Gabbay YB, Freitas RB, da Rosa EST, Mascarenhas JDP, Loureiro ECB (1989) Longitudinal study of rotavirus infections among children from Belem, Brazil. Epidem Infect 102:129–145.

    Article  CAS  Google Scholar 

  • Losonsky GA, Renneis MB, Lim Y, Krall G, Kapikian AZ, Levine MM (1988) Systemic and mucosal immune responses to rhesus rotavirus vaccine MMU 18006. Pediatr Infect Dis J 7:388–393.

    Article  PubMed  CAS  Google Scholar 

  • Mata L, Simhon A, Urrutia JJ, Kronmal RA, Fernandez R, Garcia L (1983) Epidemiology of rotaviruses in a cohort of 45 Guatemalan Mayan Indian children observed from birth to the age of three years. J Infect Dis 148:452–461.

    Article  PubMed  CAS  Google Scholar 

  • Matsui SM, Offit PA, Vo PT, Mackow ER, Benfield DA, Shaw RD, Padilla-Noriega L, Greenberg HB, (1989) Passive protection against rotavirus-induced diarrhea by monoclonal antibodies to the heterotypic neutralization domain of VP7 and the VP8 fragment of VP4. J Clin Microbiol 27:780–782.

    PubMed  CAS  Google Scholar 

  • Mebus CA, Underdahl NR, Rhodes MB, Twiehaus MJ (1969) Calf diarrhoea (scours): reproduced with a virus from a field outbreak. Bull Neb Agric Exp Station 233:1–16.

    Google Scholar 

  • McLean B, Holmes IH (1980) Transfer of antirotaviral antibodies from mothers to their infants. J Clin Microbiol 12:320–325.

    PubMed  CAS  Google Scholar 

  • Offit PA, Shaw RD, Greenberg HB (1986) Passive protection against rotavirus-induced diarrhea by monoclonal antibodies to surface proteins VP3 and VP7. J Virol 58:700–703.

    PubMed  CAS  Google Scholar 

  • Offit PA, Dudzik KI (1988) Rota virus-specific cytotoxic T lymphocytes cross-react with target cells infected with different rotavirus serotypes. J Virol 62:127–131.

    PubMed  CAS  Google Scholar 

  • Offit PA, Dudzik KI (1989) Rotavirus-specific cytotoxic T lymphocytes appear at the intestinal mucosal surface after rotavirus infection. J virol 63:3507–3512.

    PubMed  CAS  Google Scholar 

  • Pearson GR, McNulty MS (1977) Pathological changes in the small intestine of neonatal pigs infected with a pig reovirus-like agent (rotavirus). J Comp Pathol 87:363–375.

    Article  PubMed  CAS  Google Scholar 

  • Pedley S, Hundley F, Chrystie I, McCrae MA, Desselberger U (1984) The genomes of rotaviruses isolated from chronically infected immune deficient children. J Gen Virol 65: 1141–1150.

    Article  PubMed  CAS  Google Scholar 

  • Pickering LK, Bartlett III AV, Reves RR, Morrow A (1988) Asymptomatic excretion of rotavirus before and after rotavirus diarrhoea in children in day care centres. J Pediatr 112:361–365.

    Article  PubMed  CAS  Google Scholar 

  • Pitson GA, Grimwood K, Coulson BS, Oberklaid F, Hewstone AS, Jack I, Bishop RF, Barnes GL (1986) Rotavirus and other enteric pathogens associated with acute diarrhoea in children in Melbourne Australia: comparison between children treated at home and those requiring hospital admission. J Clin Microbiol 24:395–399.

    PubMed  CAS  Google Scholar 

  • Puerto FI, Padilla-Noriega L, Zamora-Chavez A, Briceno A, Puerto M, Arias CF (1987) Prevalent patterns of serotype-specific seroconversion in Mexican children infected with rotavirus. J Clin Microbiol 25:960–963.

    PubMed  CAS  Google Scholar 

  • Rahman MM, Yamauchi M, Hanada N, Nishikawa K, Marishima T (1987) Local production of rotavirus specific IgA in breast tissue and transfer to neonates. Arch Dis Child 62:401–405.

    Article  PubMed  CAS  Google Scholar 

  • Ramig RF (1988) The effects of host age, virus dose and virus strain on heterologous rotavirus infection of suckling mice. Microbiol Pathogenesis 4:189–202.

    Article  CAS  Google Scholar 

  • Rennels MB, Losonksy GA, Shindledecker CL, Hughes TP, Kapikian AZ, Levine MM, The Clinical Study Group. (1987) Immunogenicity and reac-togenicity of lowered doses of rhesus rotavirus vaccine strain MMU18006 in young children. Pediatr Infect Dis 6:260–264.

    Article  CAS  Google Scholar 

  • Riepenhoff-Talty M, Bogger-Goren S, Li P, Carmody PJ, Barrett HJ, Ogra PL (1981) Development of serum and intestinal antibody response to rotavirus after naturally acquired rotavirus infection in man. J Med Virol 8:215–222.

    PubMed  CAS  Google Scholar 

  • Ringenbergs M, Albert MJ, Davidson GP, Goldsworthy W, Haslam R (1988) Serotype-specific antibodies to rotavirus in human colostrum and breast milk and in maternal and cord blood. J Infect Dis 158:477–479.

    Article  PubMed  CAS  Google Scholar 

  • Ritz J (1989) The role of natural killer cells in immune surveillance. N Engl J Med 320:1748–1749.

    Article  PubMed  CAS  Google Scholar 

  • Rodriguez WJ, Kim HW, Brandt CD, Bize B, Kapikian AZ, Chanock RM, Curlin G, Parrott RH (1980) Rotavirus gastroenteritis in the Washington DC area: incidence of cases resulting in admission to the hospital. Am J Dis Child 134: 777–779.

    PubMed  CAS  Google Scholar 

  • Rodriguez WJ, Kim HW, Brandt CD, Schwartz RH, Gardner MK, Jeffries B, Parrott RH, Kaslow RA, Smith JI, Kapikian AZ (1987) Longitudinal study of rotavirus infection and gastroenteritis in families served by a pediatric medical practice: clinical and epidemiologic observations. Pediatr Infect Dis 6:170–176.

    Article  CAS  Google Scholar 

  • Ryder RW, Singh N, Reeves WC, Kapikian AZ, Greenberg HB, Sack RB (1985) Evidence of immunity induced by naturally acquired rotavirus and Nor-walk virus infection on two remote Panamanian islands. J Infect Dis 151:99–105.

    Article  PubMed  CAS  Google Scholar 

  • Sack DA, Gilman RH, Kapikian AZ, Aziz KMS (1980) Seroepidemiology of rotavirus infection in rural Bangladesh. J Clin Microbiol 11:530–532.

    PubMed  CAS  Google Scholar 

  • Saulsbury FT, Winkelstein JA, Yolken RH (1980) Chronic rotavirus infection in immunodeficiency. J Pediatr 97:61–65.

    Article  PubMed  CAS  Google Scholar 

  • Shaw RD, Fong KJ, Losonsky GA, Levine MM, Maldonado Y, Yolken R, Flores J, Kapikian AZ, Vo PT, Greenberg HB (1987) Epitope specific immune responses to rotavirus vaccination. Gastroent 93:941–947.

    CAS  Google Scholar 

  • Sheridan JF, Aurelian L, Barbour G, Santosham M, Sack RB, Ryder RW (1981) Traveller’s diarrhoea associated with rotavirus infection: analysis of virus-specific immunoglobulin classes. Infect Immun 39:917–927.

    Google Scholar 

  • Shinozaki T, Araki K, Ushijima H, Fujii R (1986a) Diagnostic significance of specific IgA coproconversion in rotavirus infection. Eur J Pediatr 145:581–582.

    Article  PubMed  CAS  Google Scholar 

  • Shinozaki T, Araki K, Ushijina H, Kim B, Tajima T, Fujii R, Minamitani M (1986b) Coproantibody response to rotavirus in an outbreak in a day-care nursery. Eur J Pediatr 144:515–516.

    Article  PubMed  CAS  Google Scholar 

  • Snodgrass DR, Wells PW (1978) Passive immunity in rotavirus infections. JAVMA 173:565–568.

    PubMed  CAS  Google Scholar 

  • Sonza S, Holmes IH (1980) Coproantibody response to rotavirus infection. Med J Aust 2:496–499.

    PubMed  CAS  Google Scholar 

  • Stals F, Walther FJ, Bruggeman CA (1984) Fecal and pharyngeal shedding of rotavirus and rotavirus IgA in children with diarrhoea. J Med Virol 14:333–339.

    Article  PubMed  CAS  Google Scholar 

  • Steele AD, Bos P, Alexander JJ (1988) Clinical features of acute infantile gastroenteritis associated with human rotavirus subgroups I and II. J Clin Microbiol 26:2647–2649.

    PubMed  CAS  Google Scholar 

  • Steinhoff MC (1980) Rotavirus: The first five years. J Pediatr 96:611–622.

    Article  PubMed  CAS  Google Scholar 

  • Svensson L, Sheshberadaran H, Vene S, Norrby E, Grandien M, Wadell G (1987a) Serum antibody responses to individual viral polypeptides in human rotavirus infections. J gen Virol 68:643–651.

    Article  PubMed  CAS  Google Scholar 

  • Svensson L, Sheshberadaran H, Vesikari T, Norrby E, Wadell G (1987b) Immune response to rotavirus polypeptides after vaccination with heterolo-gous rotavirus vaccines (RIT4237, RRV-1). J gen Virol 68:1993–1999.

    Article  PubMed  CAS  Google Scholar 

  • Taniguchi K, Morita Y, Urasawa T, Urasawa (1987) Cross-reactive neutralization epitopes on VP3 of human rotavirus: analysis with monoclonal antibodies and antigenic variants. J Virol 61:1726–1730.

    PubMed  CAS  Google Scholar 

  • Totterdell BM, Patel S, Banatvala JE, Chrystie IL (1988a) Development of a lymphocyte transformation assay for rotavirus in whole blood and breast milk. J Med Virol 25:27–36.

    Article  PubMed  CAS  Google Scholar 

  • Totterdell BM, Banatvala JE, Chrystie IL, Ball G, Cubitt WD (1988b) Systemic lymphoproliferative responses to rotavirus. J Med Virol 25:37–44.

    Article  PubMed  CAS  Google Scholar 

  • Uhnoo I, Svensson L (1986) Clinical and epidemiological features of acute infantile gastroenteritis associated with human rotavirus subgroups 1 and 2. J Clin Microbiol 23:551–555.

    PubMed  CAS  Google Scholar 

  • Ushijima H, Honma H, Ohnoda H, Mukoyama J, Oyanagi H, Araki K, Shinozaki T, Morikawa S, Kitamura T (1989) Detection of anti-rotavirus IgG, IgM and IgA antibodies in healthy subjects, rotavirus infections and immunodeficiences by immunoblotting. J Med Virol 27:13–18.

    Article  PubMed  CAS  Google Scholar 

  • Ward RL, Bernstein DI, Young EC, Sherwood JR, Knowlton DR, Schiff GM (1986) Human rotavirus studies in volunteers: determination of infectious dose and serological response to infection. J Infect Dis 154:871–880.

    Article  PubMed  CAS  Google Scholar 

  • Ward RL, Knowlton DR, Schiff GM, Hoshino Y, Greenberg HB (1988) Relative concentrations of serum neutralizing anitbody to VP3 and VP7 proteins in adults infected with a human rotavirus. J Virol 62:1543–1549.

    PubMed  CAS  Google Scholar 

  • Ward RL, Bernstein DI, Shukla R, Young EC, Sherwood JR, McNeal MM, Walker MC, Schiff GM (1989) Effects of antibody to rotavirus on protection of adults challenged with a human rotavirus. J Infect Dis 159:79–88.

    Article  PubMed  CAS  Google Scholar 

  • Wolf JL, Cukor G, Blacklow NR, Dambrauskas R, Trier JS (1981) Susceptibility of mice to rotavirus infection: effects of age and administration of corticos-teroids. Infect Immunity 33:565–574.

    CAS  Google Scholar 

  • Wood DJ, David TJ, Chrystie IL, Totterdell B (1988) Chronic enteric virus infection in two T-cell immunodeficient children. J Med Virol 24:435–444.

    Article  PubMed  CAS  Google Scholar 

  • Wright PF, Tajima T, Thompson J, Kokubun K, Kapikian A, Karzon DT (1987) Candidate rotavirus vaccine (rhesus rotavirus strain) in children: an evaluation. Pediatrics 80:473–479.

    PubMed  CAS  Google Scholar 

  • Yamaguchi H, Inouye S, Yamauchi M, Morishima T, Matsuno S, Isomura S, Suzuki S (1985) Anamnestic response in fecal IgA antibody production after rotaviral infection of infants. J Infect Dis 152:398–400.

    Article  PubMed  CAS  Google Scholar 

  • Yolken RH, Wyatt RG, Kim HW, Kapikian AZ, Chanock RM (1978) Immuno-logical response to infection with human reovirus-like agent: measurement of anti-human reovirus-like agent immunoglobulin G and M levels by the method of enzyme-linked immunosorbent assay. Infect Immun 19:540–546.

    PubMed  CAS  Google Scholar 

  • Zheng B, Han S, Yan Y, Liang X, Ma G, Yang Y, Ng MH (1988) Development of neutralizing antibodies and Group A common antibodies against natural infections with human rotavirus. J Clin Microbiol 26:1506–1512.

    PubMed  CAS  Google Scholar 

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Authors and Affiliations

  1. Department of Gastroenterology, Royal Children’s Hospital, Melbourne, 3052, Australia

    Ruth Bishop, Jennifer Lund, Elizabeth Cipriani, Leanne Unicomb & Graeme Barnes

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  1. Ruth Bishop
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  2. Jennifer Lund
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  3. Elizabeth Cipriani
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  4. Leanne Unicomb
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  5. Graeme Barnes
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  1. Irvine Medical Center, University of California, Orange, California, USA

    Luis M. de la Maza  & Ellena M. Peterson  & 

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© 1991 Springer Science+Business Media New York

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Bishop, R., Lund, J., Cipriani, E., Unicomb, L., Barnes, G. (1991). Clinical Serological and Intestinal Immune Responses to Rotavirus Infection of Humans. In: de la Maza, L.M., Peterson, E.M. (eds) Medical Virology 9. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-5856-5_5

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  • DOI: https://doi.org/10.1007/978-1-4684-5856-5_5

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