Abstract
Since the discovery of acyclovir, many compounds have been proposed as candidates for a new antiherpesviral agent for clinical use. They are acyclic guanosine analogues, 5-substituted deoxypyrimidine derivatives, and 2’-fluoroarabinosylpyrimidine nucleosides. However, only ganciclovir has been approved for clinical use. The reasons the others have not been developed as new agents are thought to be that (i) they are not as potent as acyclovir, (ii) their antiviral spectrum is similar to that of acyclovir, and (iii) their toxicity is not as low as that of acyclovir.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Machida, H., Sakata, S., Kuninaka, A., Yoshino, H., Nakayama, C.and Saneyoshi, M. (1979) Antimicrob. Agents Chemother. 16, 158–163.
Machida, H., Kuninaka, A., Yoshino, H., Ikeda, K.and Mizuno, Y. (1980) Antimicrob. Agents Chemother. 17, 1030–1031.
Sakata, S., Shibuya, S., Machida, H., Yoshino, H., Hirota, K., Senda, S., Ikeda, K.and Mizuno, Y. (1980) Nucleic Acids Res. Symp. Ser. 8, S39 - S42.
Machida, H., Sakata, S., Kuninaka, A.and Yoshino, H. (1981) Antimicrob. Agents Chemother. 20, 47–52.
Machida, H., Kuninaka, A.and Yoshino, H. (1982) Antimicrob. Agents Chemother. 21, 358–361.
Machida, H.and Takezawa, T. (1990) Antimicrob. Agents Chemother. 34 no. 5.
Nagafuchi, S., Oda, H., Mori, R.and Taniguchi, T. (1979) J. Gen. Virol. 44, 715–723.
Kumagai, M., Sakata, S., Yamaguchi, T., Ikeda, K.and Machida, H. (1989) J. Labelled Compd. Radiopharm. 27, 503–507.
Suzutani, T., Machida, H., Sakuma, T.and Azuma, M. (1988) Antimicrob. Agents Chemother. 32, 1547–1551.
Yokota, T., Konno, K., Mori, S., Shigeta, S., Kumagai, M., Watanabe, Y.and Machida, H. (1989) Mol. PharmacoL 36, 312–316.
Machida, H. (1986) Antimicrob. Agents Chemother. 29, 524–526.
Machida, H. (1986) Biken J. 29, 1–6.
Lin, J.-C.and Machida, H. (1988) Antimicrob. Agents Chemother. 32, 1068–1072.
Machida, H., Sakata, S.and Saito, K. (1985) in Herpes Viruses and Virus Chemotherapy, ed. Kono, R.and Nakajima, A. ( Excerpta Medica, Amsterdam ), pp. 63–66.
Cheng, Y.-C., Dutschman, G., Fox, J. J., Watanabe, K. A.and Machida, H. (1981) Antimicrob. Agents Chemother. 20, 420–423.
Ruth, J. L.and Cheng, Y.-C. (1981) Mol. PharmacoL 20, 415–422.
Descamps, J., Sehgal, R. K., De Clercq, E.and Allaudeen, H. S. (1982) J. Virol. 43, 332–336.
Shigeta, S., Yokota, T., Iwabuchi, T., Baba, M., Konno, K., Ogata, M.and De Clercq, E. (1983) J. Infect. Dis. 147, 576–584.
Suzutani, T., Machida, H.and Sakuma, T. (1988)Antimicrob. Agents Chemother. 32, 1046–1052.
Machida, H.and Sakata, S. (1984) Antiviral Res. 4, 135–141.
Reefschläger, J., Wutzler, P., Thiel. K.-D.and Herrmann, G. (1986) Antiviral Res. 6, 83–93.
Kern, E. R., Richards, J. T.and Overall, J. C., Jr. (1986) Antiviral Res. 6, 189–195.
Park, N.-H., Pavan-Langston, D., McLean, S. L.and Albert, D. M. (1979) Antimicrob. Agents Chemother. 15, 775–779.
Fyfe, J. A. (1982) MoL PharmacoL 21, 432–437.
Ayisi, N. K., Wall, R. A., Wanklin, R. J., Machida, H., De Clercq, E.and Sacks, S. L. (1987) Mol. PharmacoL 31, 422–429.
Soike, K. F., Baskin, G., Cantrell, C.and Gerone, P. (1984) Antiviral Res. 4, 245–257.
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1990 Plenum Press, New York
About this chapter
Cite this chapter
Machida, H. (1990). Brovavir: Its Antiherpesviral Activity and Mode of Action. In: Lopez, C., Mori, R., Roizman, B., Whitley, R.J. (eds) Immunobiology and Prophylaxis of Human Herpesvirus Infections. Advances in Experimental Medicine and Biology, vol 278. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-5853-4_26
Download citation
DOI: https://doi.org/10.1007/978-1-4684-5853-4_26
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4684-5855-8
Online ISBN: 978-1-4684-5853-4
eBook Packages: Springer Book Archive