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Regulation of Expression of the Glycoprotein Genes of Herpes Simplex Virus Type 1 (HSV-1)

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Immunobiology and Prophylaxis of Human Herpesvirus Infections

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 278))

Abstract

Herpes simplex virus (HSV) genes are expressed during infection as three groups; immediate early, early, and late, or α, β, and γ, in a coordinately regulated and sequentially ordered cascade manner (1, 2). The a genes are transcribed by the RNA polymerase II of the host cell in the absence of newly synthesized viral proteins. Functional a proteins are necessary for the transcription of β and γ genes (1, 2). The Q products are involved in the replication of viral DNA (3). Late genes constitute two subclasses, γ 1 and γ 2, differing in their dependence upon viral DNA synthesis for expression. Inhibition of viral DNA replication effects a moderate decrease in the accumulation of γ 1 mRNAs, whereas the messages of γ2 genes are not detected (4, 5). Most of the γ gene products are structural proteins of the virion. These structural proteins include at least seven envelope glycoproteins (6, 7, 8, 9), which are also found in the membranes of infected cells.

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Author information

Authors and Affiliations

  1. Department of Human Genetics, University of Michigan Medical School, Ann Arbor, Michigan, 48109-0618, USA

    Myron Levine & Alexandra Krikos

  2. Department of Microbiology, Biochemistry and Molecular Biology, University of Pittsburgh, Pittsburgh, Pennsylvania, 15261, USA

    Joseph C. Glorioso

  3. The Upjohn Company, Kalamazoo, Michigan, 49001, USA

    Fred L. Homa

Authors
  1. Myron Levine
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  2. Alexandra Krikos
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  3. Joseph C. Glorioso
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  4. Fred L. Homa
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Editor information

Editors and Affiliations

  1. Eli Lilly and Company, Indianapolis, Indiana, USA

    Carlos Lopez

  2. Kyushu University, Fukuoka, Japan

    Ryoichi Mori

  3. The University of Chicago, Chicago, Illinois, USA

    Bernard Roizman

  4. University of Alabama at Birmingham, Birmingham, Alabama, USA

    Richard J. Whitley

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© 1990 Plenum Press, New York

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Levine, M., Krikos, A., Glorioso, J.C., Homa, F.L. (1990). Regulation of Expression of the Glycoprotein Genes of Herpes Simplex Virus Type 1 (HSV-1). In: Lopez, C., Mori, R., Roizman, B., Whitley, R.J. (eds) Immunobiology and Prophylaxis of Human Herpesvirus Infections. Advances in Experimental Medicine and Biology, vol 278. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-5853-4_16

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  • DOI: https://doi.org/10.1007/978-1-4684-5853-4_16

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4684-5855-8

  • Online ISBN: 978-1-4684-5853-4

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