Abstract
Genotoxic carcinogens are black list substances, whose discharge via wastewater should be reduced by best technical means. Detection of carcinogens as such in wastewater is at present nearly impossible. Identification combined with a literature search on the toxic properties is therefore still a favored approach, for want of something better. A major part of the discharged effluent will escape scrutiny, however, either because identification is not possible, or because toxicological information about identified compounds is not available.
This paper is dedicated to the memory of Professor André Jaylet (deceased May 29, 1989) who should have been among us in Washington.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
AWWA (1988) The search for surrogates. In Cooperative Research Report, KIWA-AWWA-RF, Denver, Colorado.
Barna, J. (1983) Ineffectiveness of irradiate spice mixture in DLT. Mutat. Res. 113:231.
Choroulinkoff, I., and A. Jaylet (1989) Contamination of aquatic systems and genetic effects (Part 4). In Aquatic Ecotoxicology. Fundamental Concepts and Methodologies, A. Boudo and F.S. Ribeyres, eds. CRC Press Inc. pp. 211–235.
Das, R.K., and N.K. Nanda (1986) Induction of micronuclei in peripheral erythrocytes of fish Heteropneustes fossilis by mitomycin C and paper mill effluent. Mutat. Res. 175:67–71.
Denkhaus, R., W.O. Grabow, and O.W. Prozesky (1980) Removal of mutagenic compounds in a waste water reclamation system evaluated by means of the Ames Salmonella/microsome assay. Prog. Water Tech. 12:571–589.
De Raat, W.K., A.O. Hanstveit, and J.F. de Kreuk (1985) The role of mutagenicity testing in the ecotoxicological evaluation of industrial discharges into the aquatic environment. Fd. Chem. Tox. 23:33–41.
Dixon, D.R., and K.R. Clarke (1982) Sister chromatid exchange: A sensitive method for detecting damage caused by exposure to environmental mutagens in the chromosomes of adult Mytilus edulis. Mar. Biol. Lett. 3:163–172.
Harrison, F.L., and I.M. Jones (1982) An in vivo sister-chromatid exchange assay in the larvae of the mussel. Mytilus edulis: Response to 3 mutagens. Mutat. Res. 105:235–242.
Hooftman, R.N. (1981) The induction of chromosomal aberrations in Nothobranchius rachowi after treatment with ethyl methane sul-phonate or benzo[α]pyrene. Mutat. Res. 91:347–352.
Hooftman, R.N., and W.K. de Raat (1982) Induction of nuclear anomalies (micronuclei) in the peripheral blood erythrocytes of the eastern mudminnow, Umbra pygmaea, by ethyl methane sulphonate. Mutat. Res. 104:147–150.
Jaylet, A., and C. Zoll (1989) Tests for the detection of genotoxins in fresh water. CRC Critical Reviews in Aquatic Toxicology. CRC Press, Inc. (in press)
Jaylet, A., P. Deparis, V. Ferrier, and S. Grinfield (1986) A new micronucleus test using peripherial blood erythrocytes of the newt Pleurodeles waltl to detect mutagens in fresh water pollution. Mutat. Res. 164:245–257.
Jaylet, A., P. Deparis, and D. Gaschignard (1986) Induction of micronuclei in peripherial erythrocytes of axolotl larvae following in vivo exposure to mutagenic agents. Mutagenesis 1:211–215.
Kligerman, A.D. (1982) Fishes as biological detectors of the effects of genotoxic agents. In Mutagenicity, New Horizons in Genetic Toxicology, J. Heddle, ed., pp. 435–456.
Kramer, K.J.M., H.A. Jenner, and D. de Zwart (1989) The valve movement response of mussels: A tool in biological monitoring. Hydrobiologica (in press).
Majone, F., R. Brunetti, I. Gola, and A.G. Levis (1987) Persistence of micronuclei in the marine mussel, Mytilus galloprovincialis, after treatment with mitomycin C. Mutat. Res. 191:157–161.
Maron, D.M., and B.N. Ames (1983) Revised method for the Salmonella mutagenicity test. Mutat. Res. 113:173–215.
Meier, J.R., W. Blazak, E.S. Riccio, B.E. Stewart, D.F. Bishop, and L.W. Condie (1987) Genotoxic properties of municipal wastewaters in Ohio. Arch. Env. Contam. Tox. 16:671–680.
Noordsij, A., J. van Beveren, and A. Brandt (1983) Isolation of organic compounds from water for chemical analysis and toxicological testing. Intern. J. Env. and Analyt. Chem. 13:205–217.
Pesch, G.G., and C.E. Pesch (1980) Neanthes arenaceodentata Polychaeta: Annelida), a proposed cytogenetic model for marine genetic toxicology. Can. J. Fish. Aquat. Sci. 37:1225–1228.
Quillardet, P., and M. Hofnung (1985) The SOS chromotest, a colorimetric bacterial assay for genotoxins: Procedures. Mutat. Res. 147:65–78.
Rappaport, S.M., M.G. Richard, M.C. Hollstein, and R.E. Talcott (1979) Mutagenic activity in organic waste water concentrates. Env. Sci. Tech. 13:957–961.
Slooff, W., and D. de Zwart (1987) Continuous effluent biomonitoring with an early warning system. Naturvardsverket Rapport 3275:20–21 (Stockholm).
Tates, A.D., I. Neuteboom, M. Hofker, and L. den Engelse (1980) A micronucleus technique for detecting clastogenic effects of mutagens/carcinogens (DEN, DMN) in hepatocytes of rat liver in vivo. Mutat. Res. 74:11–20.
Van de Kerkhoff, J.F.J., and M.A. van der Gaag (1985) Some factors affecting the differential staining of sister-chromatids in vivo in the fish Nothobranchius rachowi. Mutat. Res. 143:39–43.
Van der Gaag, M.A., and J.F.J. van de Kerkhoff (1985) Mutagenicity testing of water with fish: A step forward to a reliable assay. Sci. Total Env. 47:293–298.
Van der Gaag, M.A. (1989) Rapid detection of genotoxins in waste water: New perspectives with the sister-chromatid exchange assay in vivo with Nothobranchius rachowi. In Conference Proceedings of the First European Conference on Ecotoxicology, M. Løkke, H. Tyle, and F. Bro-Rasmussen, eds. Copenhagen 259–262.
Van der Hoeven, J.C.M., I.M. Bruggeman, G.M. Alink, and J.H. Koeman (1982) The killifish Nothobranchius rachowi, a new animal in genetic toxicology. Mutat. Res. 97:35–42.
Van Hummelen, P., C. Zoll, J. Paulussen, M. Kirsch-Volders, and A. Jaylet (1989) The micronucleus test in Xenopus: A new and simple in vivo technique for detection of mutagens in fresh water. Mutagenesis 4:12–16.
Vigfusson, N.V., E.R. Vyse, C.A. Pernsteiner, and R.J. Dawson (1983). In vivo induction of sister-chromatid exchange in Umbra limi by the insecticides endrin, chlordane, diazinone and guthion. Mutat. Res., 118:61–68.
Weaver, D.L., P.K. Hopke, J.B. Johnston, and M.J. Plewa (1981) Mutagenicity of Chicago municipal sewage sludge in the Salmonella/microsome reverse mutation assay. Env. Muta. 3:350.
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1990 Plenum Press, New York
About this chapter
Cite this chapter
van der Gaag, M.A., Gauthier, L., Noordsij, A., Levi, Y., Wrisberg, M.N. (1990). Methods to Measure Genotoxins in Wastewater: Evaluation with in vivo and in vitro Tests. In: Waters, M.D., Daniel, F.B., Lewtas, J., Moore, M.M., Nesnow, S. (eds) Genetic Toxicology of Complex Mixtures. Environmental Science Research, vol 39. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-5850-3_17
Download citation
DOI: https://doi.org/10.1007/978-1-4684-5850-3_17
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4684-5852-7
Online ISBN: 978-1-4684-5850-3
eBook Packages: Springer Book Archive