Abstract
Astrocytes play important roles in the complex neuronal and glial response to brain injury and pathological neuronal loss. Also referred as gliosis, this process is usually characterized by extensive astroglial hypertrophy and proliferation. In addition, reactive astrocytes undergo numerous cytological, biochemical and histochemical changes, including accumulation of vimentin, glycogen, increased oxidoreductive enzyme activity and most notably, increased accumulation of glial fibrillary acidic protein (GFAP) (Bignami and Dahl, 1976). Reactive astrocytes appear to be involved in healing responses to neuron injury by scavenging myelin and neuronal debris (Lee et al., 1977) and by releasing soluble proteins in their microenvironment which often have neurotrophic properties.
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References
Bignami, A. and Dahl, D., 1976, Astroglial response to stabbing. Immunofluorescence studies with antibodies to astrocytes specific protein (GFA). Neurovathol. Appl. Neurobiol. 2: 99.
Boyles, J.K., Pitas, R.E., Wilson, E., Mahley, R.W. and Taylor, J.M., 1985, Apolipoprotein E associated with astrocytic glia of the central nervous system and with non myelinating glia of the peripheral nervous system, J. Clin. Invest. 76: 1501.
Cotman, C.W. and Anderson, K.J., 1987, Synaptic plasticity and functional stabilization in the hippocampal formation: possible role in Alzheimer’s disease, Adv. Neurol. 47: 313.
de Ruiter, J.P. and Uylings, H.B.M., 1987, Morphometric and dendritic analysis of fascia dentata granule cells in human aging and senile dementia, Brain Res. 40: 217.
Flood, D.G. and Coleman, P.D., 1987, Failed compensatory dendritic growth as pathophysiological process in Alzheimer’s disease, Can. J. Neurol. Sci. 13: 474.
Gage, F.H., Olejniczak, P. and Armstrong, D.M., 1988, Astrocytes are important for sprouting in the septohippocampal circuit, Exp. Neurol. 102: 2.
Gall, C., Rose, G. and Lynch, G.S., 1979, Proliferative and migratory activity of glial cells in the partially deafferented hippocampus, J. Comp. Neurol. 183: 539.
Geddes, J.W., Monaghan, D.T., Cotman, C.W., Lott, I.T., Kim, R.C. and Chui, H.C., 1985, Plasticity of hippocampal circuitry in Alzheimer’s disease, Science 230: 1179.
Hyman, B.T., Kromer, L.J. and Van Hoesen, G.W., 1987, Reinnervation of the hippocampal perforant pathway zone in Alzheimer’s disease, Ann. Neurol. 21: 259.
Lee, K.D., Standford, E.J., Cotman, C.W. and Lynch, G.S., 1977, Ultrastructural evidence for bouton proliferation in partially deafferented dentate gyrus in the adult rat, Exp. Brain Res. 29: 475.
Mahley, R.W., 1988, Apolipoprotein E: cholesterol transport protein with expending role in cell biology, Science 240: 622.
Muller, H.W., Ignatius, M.J., Hangen, D.H. and Shooter, E.M., 1986, Expression of specific sheet cell proteins during peripheral nerve growth and regeneration in mammals, J. Cell Biol. 102: 393.
Pitas, R.E., Boyles, J.K., Lee, S.H., Foss, D. and Mahley, R.W., 1987, Astrocytes synthesize apolipoprotein E and metabolize apolipoprotein E-containing lipoproteins, Biochem, Biophys. Acta 917: 148.
Poirier, J., May, P.C., Osterburg, H.H., Geddes, J., Cotman, C.W. and Finch, C.E., 1989, Alteration of gene expression in rat hippocampus following entorhinal cortex lesion, Proc. Natl. Acad. Sci. (in press)
Poirier, J., Hess, M., May, P.C. and Finch, C.E., 1988, Alteration of the glial fibrillary acidic protein in the rat hippocampus following entorhinal cortex lesion, Soc. Neurosci. Abst. 14: 897.
Represa, A., Duyckaerts, C., Tremblay, E., Hauw, J.J. and Ben-Ari, Y., 1988, Is senile dementia of Alzheimer type associated with hippocampal plasticity, Brain Res. 457: 355.
Scheff, S.W., Benardo, S.W. and Cotman, C.W., 1980, Decline in reactive fiber growth in the dentate gyrus of aged rats compared to young adult rats following entorhinal cortex, Brain Res. 199: 21.
Steward, O., 1987, Regulation of synaptogenesis through the local synthesis of protein at the postsynaptic site, Prog. Brain Res. 71: 267.
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© 1990 Plenum Press, New York
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Poirier, J., Hess, M., May, P.C., Pasinetti, G., Finch, C.E. (1990). Astroglial Gene Expression in the Hippocampus Following Partial Deafferentation in the Rat and in Alzheimer’s Disease. In: Nagatsu, T., Fisher, A., Yoshida, M. (eds) Basic, Clinical, and Therapeutic Aspects of Alzheimer’s and Parkinson’s Diseases. Advances in Behavioral Biology, vol 38A. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-5844-2_38
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DOI: https://doi.org/10.1007/978-1-4684-5844-2_38
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