Abstract
Senile plaques (SPs) and NFTs were immunohistochemically studied in the temporal lobe of 246 autopsy brains from non-demented and demented old people, using antibodies to synthetic polypeptide (1–24) of β-protein of cerebrovascular amyloid and to human tau protein. Dementia was present in 64% of 28 cases with many NFTs, while it was present only 33% of 43 cases in which there were many SPs but a few NFTs. The rate of prevalence of β-immunoreactive SPs increased with age in both demented and non-demented subjects. It was not significantly different between non-demented group (40% of 161 cases), and senile (47% of 19 cases) or vascular (30% of 27 cases) dementia groups. These findings suggest that β-immunoreactive SPs may be related to aging but may not be closely linked to dementia.
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© 1990 Plenum Press, New York
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Kuzuhara, S., Ihara, Y., Shimada, H., Toyokura, Y. (1990). β-Amyloid Plaques and Dementia: An Immunohistochemical Study. In: Nagatsu, T., Fisher, A., Yoshida, M. (eds) Basic, Clinical, and Therapeutic Aspects of Alzheimer’s and Parkinson’s Diseases. Advances in Behavioral Biology, vol 38A. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-5844-2_21
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DOI: https://doi.org/10.1007/978-1-4684-5844-2_21
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