Ultrastructural Events Associated with Endothelial Cell Changes During the Initiation and Early Progression of Atherosclerosis
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Vascular endothelial cells maintain homeostasis by anti-adhesive and anti-fibrinolytic properties. Endothelial cell dysfunction is associated with the pathogenesis of disease processes such as inflammation and atherosclerosis. The study of endothelial cell function in the initiation and progression of atherosclerosis has focussed upon endothelial cell injury. It is now recognized that endothelium is altered by many means, including flow perturbations, hypercholesterolemia, endotoxin or immune complexes (Engelberg, 1989); and that a nondenuding injury, or dysfunction (Reidy, 1985) is likely to be associated with atherogenesis.
KeywordsEndothelial Cell Endothelial Cell Proliferation Monocyte Adhesion Cholesterol Feeding Macrophage Foam Cell
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