Ultrastructural Events Associated with Endothelial Cell Changes During the Initiation and Early Progression of Atherosclerosis

  • Richard G. Taylor
  • W. Gray Jerome
  • Jon C. Lewis
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 273)


Vascular endothelial cells maintain homeostasis by anti-adhesive and anti-fibrinolytic properties. Endothelial cell dysfunction is associated with the pathogenesis of disease processes such as inflammation and atherosclerosis. The study of endothelial cell function in the initiation and progression of atherosclerosis has focussed upon endothelial cell injury. It is now recognized that endothelium is altered by many means, including flow perturbations, hypercholesterolemia, endotoxin or immune complexes (Engelberg, 1989); and that a nondenuding injury, or dysfunction (Reidy, 1985) is likely to be associated with atherogenesis.


Endothelial Cell Endothelial Cell Proliferation Monocyte Adhesion Cholesterol Feeding Macrophage Foam Cell 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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  1. Caplan, B.A, and Schwartz, C.J., 1973, Increased endothelial cell turnover in areas of in vivo Evans Blue uptake in the pig aorta, Atherosclerosis 17:401.PubMedCrossRefGoogle Scholar
  2. Constantinides, P., 1977, The morphological basis for altered endothelial permeability in atherosclerosis, Adv. Exp. Biol. Med. 82:969.Google Scholar
  3. Duff, G.L., McMillan, G.C., and Ritchie, A.C., 1957, The morphology of early atherosclerotic lesions of the aorta demonstrated by the surface technique in rabbits fed cholesterol, Am. J. Pathol. 33:845.PubMedGoogle Scholar
  4. Engelberg, H., 1989, Endothelium in health and disease, Sem. Thrombos. Hemostas. 15:178.PubMedCrossRefGoogle Scholar
  5. Florentin, R.A., Nam, S.C., Lee, K.T., Lee, K.J., and Thomas, W.A., 1969, Increased mitotic activity in aortas of swine after three days of cholesterol feeding, Arch. Path. 88:463.PubMedGoogle Scholar
  6. Gerrity, R.G., Richardson, M., Somer, J.B., Bell, F.P., and Schwartz, C.J., 1977, Endothelial cell morphology in areas of in vivo Evans Blue uptake in the aorta of young pigs, Am. J. Pathol. 89:313.PubMedGoogle Scholar
  7. Haust, M.D., 1971, The morphogenesis and fate of potential and early atherosclerotic lesions in man, Human Path. 2:1.CrossRefGoogle Scholar
  8. Jerome, W.G., and Lewis, J.C., 1984, Early atherogenesis in White Carneau pigeons. I. Leukocyte margination and endothelial alterations at the celiac bifurcation. Am. J. Pathol. 116:56.PubMedGoogle Scholar
  9. Jerome, W.G., and Lewis, J.C., 1985, Early atherogenesis in White Carneau pigeons. II. Ultrastructural and cytochemical observations, Am. J. Pathol. 119:210.PubMedGoogle Scholar
  10. Joris, E., Zand, T., Nunnari, J.J., Krolikowski, E.J., and Majno, G., 1983, Studies on the pathogenesis of atherosclerosis. I. Adhesion and emigration of mononuclear cells in the aorta of hypercholesterolemic rats, Am. J. Pathol. 113:341.PubMedGoogle Scholar
  11. Lewis, J.C., Taylor, R.G., Jones, N.D., St. Clair, R.W., Cornhill, J.F., 1982, Endothelial surface characteristics in pigeon coronary artery atherosclerosis. I. Cellular alterations during the initial stages of dietary cholesterol challenge, Lab. Invest. 46:123.PubMedGoogle Scholar
  12. Lewis, J.C., Taylor, R.G., and Jerome, W.G., 1985, Foam cell characteristics in coronary arteries and aortas of White Carneau pigeons with moderate hypercholesterolemia, Ann. N.Y. Acad. Sci. 454:91.PubMedCrossRefGoogle Scholar
  13. Prichard, R.W., Clarkson, T.B., Lofland, H.B., and Goodman, H.O., 1963, Myocardial infarcts in pigeons, Am. J. Pathol. 43:651.PubMedGoogle Scholar
  14. Prichard, R.W., Clarkson, T.B., Goodman, H.O., and Lofland, H.B., 1964, Aortic atherosclerosis in pigeons and its complications, Arch. Pathol. 77:244.PubMedGoogle Scholar
  15. Reidy, M.A., 1985, Biology of Disease. A reassessment of endothelial injury and arterial lesion formation, Lab. Invest. 53:513.PubMedGoogle Scholar
  16. Sarphie, T.G., 1986, A cytochemical study of the surface properties of aortic and mitral valve endothelium from hypercholesterolemic rabbits, Exp. Molec. Pathol. 44:281.CrossRefGoogle Scholar
  17. Schwartz, C.J., Sprague, E.A., Kelley, J.L., Valente, A.J., and Suenram, CA., 1985, Aortic intimai monocyte recruitment in the normo and hypercholesterolemic baboon (Papio cynocephalus). An ultrastructural study: Implications in atherogenesis, Virchows Arch [Pathol Anat] 405:175.CrossRefGoogle Scholar
  18. Schwenke, D.C., and Carew, T.E., 1989, Initiation of atherosclerotic lesions in cholesterol-fed rabbits. II. Selective retention of LDL vs. selective increases in LDL permeability in susceptible sites of arteries, Arteriosclerosis 9:908.PubMedCrossRefGoogle Scholar
  19. St. Clair, R.W., 1983, Metabolic changes in the arterial wall associated with atherosclerosis in the pigeon, Fed. Proc. 42:2480.Google Scholar
  20. Stary, H.C., 1974, Proliferation of arterial cells in atherosclerosis, Adv. Exp. Med. Biol. 43:59.PubMedGoogle Scholar
  21. Taylor, R.G., and Lewis, J.C., 1986, Endothelial cell proliferation and monocyte adhesion to atherosclerotic lesions of White Carneau pigeons, Am. J. Pathol. 125:152.PubMedGoogle Scholar
  22. Vlodavsky, I., and Gospodarowicz, D., 1979, Structural and functional alterations in the surface of vascular endothelial cells associated with the formation of a confluent cell monolayer and with the withdrawal of fibroblast growth factor, J. Supramolec. Struct. 12:73.CrossRefGoogle Scholar
  23. Weber, G., 1977, The influence of hypercholesterolemia upon endothelial glycocalyx. Adv. Exp. Med. Biol. 82:975.PubMedGoogle Scholar

Copyright information

© Plenum Press, New York 1990

Authors and Affiliations

  • Richard G. Taylor
    • 1
  • W. Gray Jerome
    • 1
  • Jon C. Lewis
    • 1
  1. 1.Department of PathologyBowman Gray School of Medicine of Wake Forest UniversityWinston-SalemUSA

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