Cigarette Smoking and Endothelial Injury: A Review

  • R. Michael Pittilo
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 273)


There is overwhelming epidemiological evidence that an association exists between cigarette smoking and cardiovascular disease, in particular atherosclerosis (Auerbach et al., 1965, 1976; Auerbach and Garfinkel 1980; Dawber et al., 1959; Doll and Peto, 1976; Eastcott, 1962; Kannel et al., 1976; Laing et al., 1981; Murphy and Mustard, 1966; Sackett et al., 1968; Spain and Bradess, 1970; Strong and Richards, 1976). Despite these considerable epidemiological data, the component or components of cigarette smoke responsible for this relationship and the mechanisms through which they mediate their effects remain unknown.


Cigarette Smoke Umbilical Artery Endothelial Injury Cigarette Smoke Extract Luminal Membrane 
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Copyright information

© Plenum Press, New York 1990

Authors and Affiliations

  • R. Michael Pittilo
    • 1
  1. 1.School of Life SciencesKingston PolytechnicKingston upon Thames, SurreyUK

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