Effects of Cigarette Smoking on Coronary Vascular Dynamics: Relationship to Coronary Atherosclerosis

  • Lloyd W. Klein
  • Annabelle S. Volgman
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 273)


Substantial evidence has been elucidated regarding the mechanisms that link cigarette smoking with the development and accelerated progression of atherosclerosis. Influences on platelet function, lipid metabolism, coronary artery tone, the sympathetic nervous system, the endocrine system, and oxygen transfer and dissociation from hemoglobin have been identified. The purpose of this chapter is to review previous work outlining the effect of smoking on coronary and systemic hemodynamics, and to discuss how repetitive alterations in vascular tone may be an integral part of the pathway by which smoking leads to an increased risk of coronary atherosclerosis.


Cigarette Smoking Coronary Blood Flow Cigarette Smoke Extract Myocardial Oxygen Demand Chronic Smoker 
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Copyright information

© Plenum Press, New York 1990

Authors and Affiliations

  • Lloyd W. Klein
    • 1
    • 2
  • Annabelle S. Volgman
    • 1
    • 2
  1. 1.Northwestern Memorial HospitalChicagoUSA
  2. 2.Northwestern University Medical SchoolChicagoUSA

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