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Tobacco Smoking and Atherosclerosis pp 273–280Cite as

Cigarette Smoking Causes Acute Changes in Arterial Wall Mechanics and the Pattern of Arterial Blood Flow in Healthy Subjects: Possible Insight into Mechanisms of Atherogenesis

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Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 273))

Abstract

Cigarette smoking is widely believed to increase the extent and severity of atherosclerosis, but the underlying mechanisms have not been delineated (1–5). There are changes in the plasma lipids and the rheology of the blood in smokers, but these are unable fully to account for atherosclerosis, in particular its focal distribution in the circulation. Atherosclerosis principally affects the intima of thick-walled arteries and within these vessels’ regions of branching and curvature. There is evidence consistent with the view that the mass transport properties of the walls of blood vessels and the blood flow pattern determine this distribution. We consider the mechanisms and report acute changes we have found in arterial wall mechanics and arterial blood flow in healthy human subjects after smoking cigarettes. These changes may help explain the association between smoking and other factors and atherosclerosis.

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Authors and Affiliations

  1. Centre for Biological and Medical Systems, Imperial College of Science, Technology and Medicine, London, SW7 2AZ, UK

    Colin G. Caro

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  1. Colin G. Caro
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Editors and Affiliations

  1. Tobacco and Health Research Institute, University of Kentucky, Lexington, Kentucky, USA

    John N. Diana

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© 1990 Plenum Press, New York

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Caro, C.G. (1990). Cigarette Smoking Causes Acute Changes in Arterial Wall Mechanics and the Pattern of Arterial Blood Flow in Healthy Subjects: Possible Insight into Mechanisms of Atherogenesis. In: Diana, J.N. (eds) Tobacco Smoking and Atherosclerosis. Advances in Experimental Medicine and Biology, vol 273. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-5829-9_27

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  • DOI: https://doi.org/10.1007/978-1-4684-5829-9_27

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4684-5831-2

  • Online ISBN: 978-1-4684-5829-9

  • eBook Packages: Springer Book Archive

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