Lipoproteins and Diet in the Pathogenesis of Atherosclerosis

  • James W. Anderson
  • Tammy L. Floore
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 273)


Atherosclerotic cardiovascular disease is a major cause of mortality and morbidity in Western countries, leading to 759,000 deaths annually in the United States1. The pathogenesis of atherosclerosis is complex, multifactorial, and involves both environmental and genetic risk factors. Steinberg2 schematically illustrated the proposed interplay of blood factors with arterial wall responses (Figure 1). Since many of these factors are discussed elsewhere,3 this review will focus on the central role of lipoproteins in atherosclerosis. Specifically, this review will examine the evidence linking dietary cholesterol and fat intake to serum lipoproteins and coronary heart disease (CHD), the strength of the relationships between atherosclerosis and serum lipoproteins, clinical trials focusing on lowering serum lipoproteins to reduce risk for CHD, animal and human regression studies, the effects of dietary fiber on serum lipoproteins and CHD, and practical implications.


Coronary Heart Disease Serum Cholesterol Dietary Fiber Coronary Heart Disease Risk Coronary Heart Disease Mortality 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Plenum Press, New York 1990

Authors and Affiliations

  • James W. Anderson
    • 1
  • Tammy L. Floore
    • 1
  1. 1.Metabolic Research Group, V.A. Medical CenterUniversity of KentuckyLexingtonUSA

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