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Effect of Nicotine and Carbon Monoxide on Prostacyclin Production by the Rabbit Heart

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Tobacco Smoking and Atherosclerosis

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 273))

Abstract

Tobacco smoking is an addictive disorder associated with excessive cardiovascular mortality (1–3). Cigarette smokers have twice the risk of death from coronary artery disease compared with their non-smoking contemporaries. Why cigarettes are addictive is not known with certainty. However, the most likely agent is nicotine (5). Bolus injections of the drug like single puffs of cigarettes result in a rapid rise in the blood concentration, a change in the sensorium and physiologic responses such as increased heart rate, a rise in the blood pressure and peripheral vasconstriction (6,7). Other compounds in this complex aerosol-carbon monoxide, tars, particulate matter, and cyanide-have potentially significantly deleterious effects on the heart and blood vessels as well as the organism as a whole.

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Authors and Affiliations

  1. Princess Alexandra Hospital, University of Queensland, Brisbane, Queensland, Australia

    David James Effeney

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  1. David James Effeney
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Editors and Affiliations

  1. Tobacco and Health Research Institute, University of Kentucky, Lexington, Kentucky, USA

    John N. Diana

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© 1990 Plenum Press, New York

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Effeney, D.J. (1990). Effect of Nicotine and Carbon Monoxide on Prostacyclin Production by the Rabbit Heart. In: Diana, J.N. (eds) Tobacco Smoking and Atherosclerosis. Advances in Experimental Medicine and Biology, vol 273. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-5829-9_22

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  • DOI: https://doi.org/10.1007/978-1-4684-5829-9_22

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4684-5831-2

  • Online ISBN: 978-1-4684-5829-9

  • eBook Packages: Springer Book Archive

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