Abstract
This symposium occurs just a little over 30 years after the landmark study of Hammond and Horn (1958) that, for the first time, conclusively linked smoking with coronary heart disease and other sequelae of atherosclerosis. The effect of that report is difficult to appreciate with our present knowledge, but one measure of its significance is that as late as 1948, coronary heart disease patients were included as controls for studies of smoking and lung cancer (Doll, 1984). Many changes have occurred since 1958: the prevalence of smoking among U.S. adults has declined by more than a half , and the coronary heart disease death rate has declined by one third. The association of smoking with atherosclerotic cardiovascular disease has been strengthened by hundreds of observational studies which have been so unanimous in their results that the question about smoking and atherosclerotic disease is no longer whether, but how. The observation that cessation of smoking reduced risk of coronary heart disease further strengthened the idea of a causal relationship. On the question of mechanisms, we are much less informed. As the presentations in this symposium will probably show, there are many possibilities, but few certainties.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Anitschov, N.N., 1967, A history of experimentation on arterial atherosclerosis in animals. in: “Cowdry’s Arteriosclerosis: A Survey of the Problem”, 2nd ed. Charles C. Thomas, Springfield, I11. p. 21–44.
Benditt, E.P., 1988, Origins of human atherosclerotic plaques. The role of altered gene expression. Arch. Pathol. Lab. Med. 112:997–1001.
Brown, M.S., and Goldstein, J.L., 1986, A receptor-mediated pathway for cholesterol homeostasis. Science 232:34–47.
Dawber, T.R., Moore, F.E., and Mann, G.V., 1957, Coronary heart disease in the Framingham Study. Am. J. Pub. Health 47(Suppl.): 4–24.
Doll, R., 1984, Smoking and death rates. JAMA 251:2854–2857.
Ernst, E., Hammerschmidt, D.E., Bagge, U., Matrai, A., and Dormandy, J.A., 1987, Leukocytes and the risk of ischemic diseases. JAMA 257:2318–2324.
Friedman, G.D., Klatsky, A.L., and Siegelaub, A.B., 1974, The leukocyte count as a predictor of myocardial infarction. N. Engl. J. Med. 290:1275–1278.
Friedman, G.D., Siegelaub, A.B., Seltzer, C.C., Feldman, R., and Collen, M.F., 1973, Smoking habits and the leukocyte count. Arch. Environ. Health 26:137–143.
Garrison, R.J., Kannel, W.B., Feinleib, M., Castelli, W.P., McNamara, P.M., and Padgett, S.J., 1978, Cigarette smoking and HDL cholesterol. The Framingham Offspring Study. Atherosclerosis 30:17–25.
Goldstein, J.L., Ho, Y.K., Basu, S.K., and Brown, M.S., 1979, Binding site on macrophages that mediates uptake and degradation of acetylated low density lipoproteins, producing massive cholesterol deposition. Proc. Natl. Acad. Sci. USA 76:333–337.
Hammond, E.C., and Horn, D., 1958, Smoking and death rates — Report on forty-four months of follow-up of 187,783 men. JAMA 166:1294–1308.
Henriksen, T., Mahoney, E.M., and Steinberg, D., 1983, Enhanced macrophage degradation of biologically modified low density lipoprotein. Arteriosclerosis 3:149–159.
Holman, R.L., McGill, H.C., Jr., Strong, J.P., and Geer, J.C., 1958, The natural history of atherosclerosis. The early aortic lesions as seen in New Orleans in the middle of the 20th century. Am. J Pathol. 34:209–235.
Ignatovski, A.I., 1908, [Influence of animal food on the organisms of rabbits].J Izv. Imp. Voyenno-Med. Akad., S.-Petersburg 16:154–176.
Kaprio, J., Ferrell, R.E., Kottke, B.A., and Sing, C.F., 1989, Smoking and reverse cholesterol transport: evidence for gene-environment interaction. Clin. Genet. 36:266–268.
Knoke, J.D., Hunninghake, D.B., and Heiss, G., 1987, Physiological markers of smoking and their relation to coronary heart disease. The Lipid Research Clinics Coronary Primary Prevention Trial. Arteriosclerosis 7:477–482.
Kondo, I., Berg, K., Drayna, D., and Lawn, R., 1989, DNA polymorphism at the locus for human cholesteryl ester transfer protein (CETP) is associated with high density lipoprotein cholesterol and apolipoprotein levels. Clin. Genet. 35:49–56.
Lipid Research Clinics Program, 1984, The Lipid Research Clinics Coronary Primary Prevention Trial Results. I. Reduction in incidence of coronary heart disease. JAMA 251:351–364.
Lusis, A.J., 1988, Genetic factors affecting blood lipoproteins: the candidate gene approach. J. Lipid Res. 29:397–429.
McGill, H.C., Jr., 1968, Fatty streaks in the coronary arteries and aorta. Lab Invest. 18:560–564.
McGill, H.C., Jr., Geer, J.C., and Strong, J.P., 1963, Natural history of human atherosclerotic lesions, in: “Atherosclerosis and Its Origin,” M. Sandler and G.H. Bourne, ed., Academic Press, New York. p. 39–65.
McGill, H.C., Jr., and Stern, M.R., 1979, Sex and atherosclerosis. Atheroscler. Rev. 4:157–242.
National Research Council, Committee on Diet and Health, 1989, “Diet and Health: Implications for Reducing Chronic Disease Risk”. Chapter 7: Fats and Other Lipids. Washington, D.C. National Academy Press. p. 159–258.
Shain, S.A., Lin, A.L., and McGill, H.C., Jr., 1988, Steroid receptors in the cardiovascular system. in: “Steroid Receptors and Disease: Cancer, Autoimmune, Bone, and Circulatory Disorders,” P.J. Sheridan, K. Blum, and M.C. Trachtenberg, eds. Marcel Dekker, Inc., New York. p. 547–567.
Scanu, A.M., 1988, Lipoprotein(a). A potential bridge between the fields of atherosclerosis and thrombosis. Arch. Pathol. Lab. Med. 112:1045–1047.
Solberg, L.A., and Strong, J.P., 1983, Risk factors and atherosclerotic lesions. A review of autopsy studies. Arteriosclerosis 3:187–198.
Stary, H.C., 1989, Evolution and progression of atherosclerotic lesions in coronary arteries of children and young adults. Arteriosclerosis 9(Suppl):I-19-I-32.
Strong, J.P., and Richards, M.L., 1976, Cigarette smoking and atherosclerosis in autopsied men. Atherosclerosis 23:451–476.
U.S. Office on Smoking and Health, 1983, “The Health Consequences of Smoking: Cardiovascular Disease; a Report of the Surgeon General”. Washington, D.C: U.S. Government Printing Office, 13–62.
Utermann, G., 1989, The mysteries of lipoprotein(a) . Science 246:904–910.
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1990 Plenum Press, New York
About this chapter
Cite this chapter
McGill, H.C. (1990). Smoking and the Pathogenesis of Atherosclerosis. In: Diana, J.N. (eds) Tobacco Smoking and Atherosclerosis. Advances in Experimental Medicine and Biology, vol 273. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-5829-9_2
Download citation
DOI: https://doi.org/10.1007/978-1-4684-5829-9_2
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4684-5831-2
Online ISBN: 978-1-4684-5829-9
eBook Packages: Springer Book Archive