Platelets in the Pathogenesis of Atherosclerosis
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The major function of platelets is to maintain the hemostatic integrity of the blood vessel and to stop bleeding after injury. Platelets show different responses that can be studied separately in vitro, but that are closely linked during hemostasis in vivo: adhesion and shape change, aggregation and secretion. Many diverse substances can activate platelets, and platelets are very sensitive to these agents and react within seconds of exposure to these stimuli. The most important physiological stimuli are von Willebrand factor and collagen, which mediate platelet adhesion; thrombin, which is generated by the coagulation system; prostaglandin endoperoxides, thromboxane, and ADP, which are released from activated platelets; platelet-activating factor, which is liberated from stimulated neutrophils and macrophages, and catecholamines, which are present in the circulation and show high levels after stress and cigarette smoking.
KeywordsNitric Oxide Platelet Aggregation Platelet Activation Foam Cell Platelet Inhibition
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- 3.Siess W., Lapetina E.G. Platelet aggregation induced by α2-adrenoceptor- and protein kinase C activation: A novel synergism. Biochem. J. in press (1989).Google Scholar
- 18.Block L.H., Knorr M., Vogt E., Locher R., Vetter W., Grosgurth P., Qiao B-Y., Pometta D., James R., Regenass M., Pletscher A. Low density lipoprotein causes general cellular activation with increased phosphatidylinositol turnover and lipoprotein catabolism. Proc. Natl. Acad. Sci. 85:885–889 (1988).PubMedCrossRefGoogle Scholar
- 27.Kaplan K.L. Platelet granule proteins: localization and secretion. In Platelets in Biology and Pathology-2, J.L. Gordon (ed) Elsevier, Amsterdam p. 80–90 (1981).Google Scholar
- 33.Leaf A., Weber P.C. Cardiovascular effects of n-3 fatty acids. N. Engl. J. Med. 318:549–557 (318).Google Scholar
- 35.Burr M.L., Gilbert J.F., Holiday R.M., Elwood P.C., Fehily A.M., Rogers S. Effects of changes in fat, fish, and fibre intakes on death and myocardial reinfarction: diet and reinfarction trial (DART). Lancet 2:758–761 (1989).Google Scholar
- 36.Weiner B.H., Ockene I.S., Levine P.H., Guenoud H., Fisher M., Johnson B.F. Inhibition of atherosclerosis by cod-liver oil in a hyperlipidemic swine model. N. Engl. J. Med. 315-841-846 (1986).Google Scholar
- 38.Turpie A.G.G. Clinical studies: Evidence for intervention with specific antiplatelet drugs in arterial thromboembolism. Semin. Thromb. Hemostas. 14:4–49 (1988).Google Scholar
- 39.ISIS-2 collaborative group. Randomized trial of intravenous streptokinase, oral aspirin, both or neither among 17187 cases of suspected acute myocardial infarction: ISIS-2. Lancet II: 349 (1988).Google Scholar
- 40.The steering committee of the physicians health study research group. Preliminary report: findings from the aspirin component of the ongoing physicians health study. N. Engl. J. Med. 318:262-(1988).Google Scholar