Effects of NH4+ on the Function of the CNS

  • W. Raabe
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 272)


Several encephalopathies are associated with hyperammonemia, example the encephalopathies associated with ureacycle disorders and portasystemic (hepatic) encephalopathy. Hyperammonemia increases NH 4 + in the CNS (21). Increases of NH 4 + in the CNS affect the function of neurons and disturb neuronal interactions. Therefore, it can be presumed that the encephalopathies associated with hyperammonemia are significantly contributed to if not solely caused by, the effects of NH 4 + on the function of neurons.


Ammonium Acetate Synaptic Transmission Rest Membrane Potential Presynaptic Terminal Neuronal Circuit 
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Copyright information

© Plenum Press, New York 1990

Authors and Affiliations

  • W. Raabe
    • 1
  1. 1.Departments of Neurology VA Medical CenterUniversity of MinnesotaMinneapolisUSA

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