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Clinical Use of Carnitine Past, Present and Future

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Cirrhosis, Hepatic Encephalopathy, and Ammonium Toxicity

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 272))

Abstract

In animals carnitine is formed from proteic lysine through a complex set of reactions, leading to deoxycarnitine, the immediate precursor of carnitine in all tissues. However the last stage, hydroxylation of deoxycarnitine to carnitine, is restricted to liver, brain and, in humans, kidney (1). Therefore other tissues can export deoxycarnitine via the blood stream to these hydroxylating tissues, but for their own endogenous carnitine depend either on the return and import of the newly synthesized compound or on an adequate dietary supply.

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Authors and Affiliations

  1. Dipartimento di Chimica Biologica and Centro Fisiologia Mitocondriale CNR, Università di Padova, Italy

    Noris Siliprandi, Fabio Di Lisa & Roberta Menabó

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  1. Noris Siliprandi
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  2. Fabio Di Lisa
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  3. Roberta Menabó
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Editors and Affiliations

  1. Instituto de Investigaciones Citológicas, Caja de Ahorros de Valencia, Valencia, Spain

    Santiago Grisolía , Vicente Felipo  & María-Dolores Miñana ,  & 

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© 1990 Plenum Press, New York

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Siliprandi, N., Di Lisa, F., Menabó, R. (1990). Clinical Use of Carnitine Past, Present and Future. In: Grisolía, S., Felipo, V., Miñana, MD. (eds) Cirrhosis, Hepatic Encephalopathy, and Ammonium Toxicity. Advances in Experimental Medicine and Biology, vol 272. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-5826-8_11

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  • DOI: https://doi.org/10.1007/978-1-4684-5826-8_11

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4684-5828-2

  • Online ISBN: 978-1-4684-5826-8

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