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Phospholipase A2 pp 103–113Cite as

Mobilization and Function of Extracellular Phospholipase A2 in Inflammation

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Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 275))

Abstract

A common characteristic of inflammatory exudates is the accumulation of relatively high concentrations of phospholipase A2 (PLA-2) in the cell-free fluid (1). Because many (by-)products or this enzyme’s action can exert pro-inflammatory effects (e.g. eicosanoid derivatives of arachidonic acid), these observations have prompted considerable speculation about the possible (patho-) physiological role of extracellular PLA-2 in inflammation. These ideas, in turn, have triggered many investigators and pharmaceutical companies alike to search for “specific” inhibitors of PLA-2 that could be applied therapeutically in acute or chronic inflammatory diseases.

This work was supported by USPHS Grants AI 18571 and R37 DK 05472

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References

  1. P. Vadas and W. Pruzanski, Role of extracellular phospholipase A2 in inflammation, Adv. Inflamm. Res. 7:51 (1984).

    CAS  Google Scholar 

  2. M. Waite, “The Phospholipases,” Plenum Press, New York (1987).

    Book  Google Scholar 

  3. P. Elsbach, J. Weiss, and S. Forst, Determinants of the action of phospholipases on the phospholipids of gram-negative bacteria (E. coli). In: Lipids and Biomembranes: Past, Present and Future. J. Op Den Kamp, B. Roelofsen and K.W.A. Wirtz, eds., pp. 259–286, Elsevier Science Publishers, Amsterdam, The Netherlands (1986).

    Google Scholar 

  4. R.M. Kini and H.J. Evans, Structure-function relationships of phospholipases. The anticoagulant region of phospholipase A2 J. Biol. Chem. 262:14402 (1987).

    CAS  Google Scholar 

  5. P. Elsbach and J. Weiss, Phagocytosis of bacteria and phospholipid degradation, Biochim. Biophys. Acta (Reviews of Biomembranes) 947:29 (1988).

    Article  CAS  PubMed  Google Scholar 

  6. G. Wright, J. Weiss and P. Elsbach, Role of extracellular and cellular phospholipases in the destruction of E. coli in an inflammatory exudate, Clin Res 36:475A (1988).

    Google Scholar 

  7. O. Doi and S. Nojima, Nature of Escherichia coli mutants deficient in detergent-resistant and/or detergent-sensitive phospholipase A, J. Biochem. 80:1247 (1976).

    CAS  PubMed  Google Scholar 

  8. P. de Geus, I. van Die, H. Bergmans, J. Tommassen and G.H. de Haas, Molecular cloning of pldA, the structural gene for outer membrane phospholipase of E. coli Kl2, Mol. Gen. Genet. 190:150 (1983).

    Article  PubMed  Google Scholar 

  9. J. Weiss, S. Beckerdite-Quagliata and P. Elsbach, Determinants of the action of phospholipases A on the envelope phospholipids of Escherichia coli, J. Biol. Chem. 254:11010 (1979).

    CAS  PubMed  Google Scholar 

  10. S. Forst, J. Weiss, and P. Elsbach, The role of phospholipase A2 lysines in phospholipolysis of Escherichia coli killed by a membrane-active neutrophil protein, J. Biol. Chem. 257:14055 (1982).

    CAS  PubMed  Google Scholar 

  11. S. Forst, J. Weiss, P. Blackburn, B. Frangione, F. Goni and P. Elsbach, Amino acid sequence of a basic Agkistrodon halys blomhoffii phospholipase A2: Possible role of NH2-terminal lysines in action on phospholipids of Escherichia coli, Biochemistry 25: 4309 (1986).

    Article  CAS  PubMed  Google Scholar 

  12. M.J. Dufton, D. Eaker and R.C. Hider, Conformational properties of phospholipases A2: Secondary structure prediction, circular dichroism and relative interface hydrophobicity, Eur. J. Biochem. 137:537 (1983).

    Article  CAS  PubMed  Google Scholar 

  13. R. Renetseder, S. Brunie, B.W. Dijkstra, J. Drenth and P.B. Sigler, A comparison of the crystal structures of phospholipase A2 from bovine pancreas and Crotalus Atrox venom, J. Biol. Chem. 260:11627 (1985).

    CAS  PubMed  Google Scholar 

  14. G.E. Schulz and R.H. Schirmer, “Principles of protein structure” Springer-Verlag, New York (1979).

    Book  Google Scholar 

  15. A. Randolph and R.L. Heinrikson, Crotalus atrox phospholipase A2. Amino acid sequence and studies on the function of the NH2-terminal region, J. Biol. Chem.257:2155 (1982).

    CAS  PubMed  Google Scholar 

  16. R. Franson, R. Dobrow, J. Weiss, P. Elsbach and W. Weglicki, Isolation and characterization of a phospholipase A2 from an inflammatory exudate, J. Lipid Res. 19:18 (1978).

    CAS  PubMed  Google Scholar 

  17. P. Elsbach, J. Weiss, R.C. Franson, S. Beckerdite-Quagliata, A. Schneider and L. Harris, Separation and purification of a potent bactericidal/permeability-lncreasing protein and a closely associated phospholipase A2 from rabbit polymorphonuclear leukocytes, J. Biol. Chem. 254;1l000 (1979:).

    Google Scholar 

  18. S. Forst, J. Weiss, P. Elsbach, J.M. Maraganore, I. Reardon and R.L. Heinrikson, Structural and functional properties of a phospholipase A2 purified from an inflammatory exudate, Biochemistry 25:8381 (1986).

    Article  CAS  PubMed  Google Scholar 

  19. R.L. Heinrikson, E.T. Krueger, and P.S. Keim, Amino acid sequence of phospholipase A2-alpha from the venom of Crotalus adamanteus: A new classification of phospholipase A2 based upon structural determinants, J.Biol. Chem. 252:4913 (1977).

    CAS  PubMed  Google Scholar 

  20. H. Mizushima, I. Kudo, K. Horigome, M. Murakami, M. Hayakawa, D.K. Kim, E. Kondo, M. Tomita and K. Inoue, Purification of rabbit platelet secretory phospholipase A2 and its characteristics, J. Biochem. 105:520 (1989).

    CAS  PubMed  Google Scholar 

  21. R.M. Kramer, C. Hession, B. Johansen, G. Hayes, P. McGray, E.P. Chow, R. Tizard and R.B. Pepinsky, Structure and properties of a human non-pancreatic phospholipase A2, J. Biol. Chem. 264: 5768 (1989).

    CAS  PubMed  Google Scholar 

  22. R. Verger, F. Ferrato, CM. Mansbach and G.Pieroni, A novel intestinal phospholipase A2: Purification and some molecular characteristics, Biochemistry 21:6883 (1982).

    Article  CAS  PubMed  Google Scholar 

  23. G.C. Wright, C. E. Ooi, J. Weiss and P. Elsbach, Purification of a cellular (granulocyte) and an extracellular (serum) phospholipase A2 that participate in the destruction of Escherichia coli in a rabbit inflammatory exudate, submitted for publication, (1989).

    Google Scholar 

  24. G. Wright, J, Weiss, J. Van den Bergh, H. Verheij and P. Elsbach, Genetic engineering of pig pancreas phospholipase A2 to convert an inactive to an active ezyme in the bactericidal/ permeability-increasing protein (BPI)-mediated bacterial phospholipolysis, Clin. Res. 37:444A (1989).

    Google Scholar 

  25. D.K. Kim, I. Kudo and K. Inoue, Detection in human platelets of phospholipase A2 activity which preferentially hydrolyzes an arachidonoyl residue, J. Biochem. 104:492 (1988).

    CAS  PubMed  Google Scholar 

  26. J.J. Seilhamer, W. Pruzanski, P. Vadas, S. Plant, J.A. Miller, J. Kloss and L.K. Johnson, Cloning and recombinant expression of phospholipase A2 present in rheumatoid arthritic synovial fluid, J. Biol. Chem. 264:5335 (1989).

    CAS  PubMed  Google Scholar 

  27. See reference # 20.

    Google Scholar 

  28. C Lanni and E.L. Becker, Release of phospholipase A2 activity from rabbit peritoneal neutrophils by f-Met-Leu-Phe, Am. J. Pathol. 113:90 (1983).

    CAS  PubMed Central  PubMed  Google Scholar 

  29. See reference # 23.

    Google Scholar 

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Author information

Authors and Affiliations

  1. Departments of Microbiology and Medicine, New York University School of Medicine, NY, NY, USA

    Jerrold Weiss & Grace Wright

Authors
  1. Jerrold Weiss
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  2. Grace Wright
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Editor information

Editors and Affiliations

  1. New York Medical College, Valhalla, New York, USA

    Patrick Y-K Wong

  2. University of California at San Diego, La Jolla, California, USA

    Edward A. Dennis

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© 1990 Plenum Press, New York

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Weiss, J., Wright, G. (1990). Mobilization and Function of Extracellular Phospholipase A2 in Inflammation. In: Wong, P.YK., Dennis, E.A. (eds) Phospholipase A2 . Advances in Experimental Medicine and Biology, vol 275. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-5805-3_6

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  • DOI: https://doi.org/10.1007/978-1-4684-5805-3_6

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4684-5807-7

  • Online ISBN: 978-1-4684-5805-3

  • eBook Packages: Springer Book Archive

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