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Phospholipase A2 pp 1–16Cite as

Macrophage Phospholipase A2 Activity and Eicosanoid Production: Studies with Phospholipase A2 Inhibitors in P388D1 Cells

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Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 275))

Abstract

The inflammatory response involves many different types of tissues and cells; a common modulator produced by many of these cells is the eicosanoids. The eicosanoids (prostaglandins, thromboxanes, leukotrienes. hydroxyeicosatetraenoic acids, lipoxins. etc.) are prominent mediators in the development of inflammatory reactions and have, therefore, been a target for therapeutic regulation. More precisely, the actual target has been the enzymes which control the first step of their biosynthesis from arachidonic acid, the cyclooxygenase and the lipoxygenase.

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References

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Author information

Authors and Affiliations

  1. Department of Chemistry, University of California at San Diego, La Jolla, California, 92093, USA

    Keith B. Glaser, Mark D. Lister & Edward A. Dennis

  2. Department of Immunology, Scripps Clinic and Research Institute, La Jolla, California, 92037, USA

    Richard J. Ulevitch

Authors
  1. Keith B. Glaser
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  2. Mark D. Lister
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  3. Richard J. Ulevitch
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  4. Edward A. Dennis
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Editor information

Editors and Affiliations

  1. New York Medical College, Valhalla, New York, USA

    Patrick Y-K Wong

  2. University of California at San Diego, La Jolla, California, USA

    Edward A. Dennis

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© 1990 Plenum Press, New York

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Glaser, K.B., Lister, M.D., Ulevitch, R.J., Dennis, E.A. (1990). Macrophage Phospholipase A2 Activity and Eicosanoid Production: Studies with Phospholipase A2 Inhibitors in P388D1 Cells. In: Wong, P.YK., Dennis, E.A. (eds) Phospholipase A2 . Advances in Experimental Medicine and Biology, vol 275. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-5805-3_1

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  • DOI: https://doi.org/10.1007/978-1-4684-5805-3_1

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4684-5807-7

  • Online ISBN: 978-1-4684-5805-3

  • eBook Packages: Springer Book Archive

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