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Circulating Regulatory Factors and Neuroendocrine Function pp 147–164Cite as

Circulating Corticotropin-Releasing Factor in Pregnancy

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Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 274))

Abstract

Normal circulating levels of human corticotropin releasing factor (hCRF), the most potent of the hypothalamic peptides stimulating pituitary ACTH release (1) are low, most workers reporting levels substantially below 100 pg/ml (2–10). This plasma CRF is thought to originate not only from the hypothalamus but also from several tissues outside of the brain such as the spinal cord, alimentary tracts, lung, pancreas, and adrenal gland, which have all been shown to contain CRF-like immunoreactivity (11–14). Release of CRF from these organs is thought to contribute a significant proportion of the CRF in the peripheral circulation, since most studies have been unable to demonstrate modulation of plasma CRF by stress and glucocorticoids (3–5,9,15,16), which would be expected if plasma CRF primarily reflected peptide release from the hypothalamus. Following the demonstration of CRF-like bioactivity (17,18) in extracts of human placenta, several reports appeared describing elevated levels of CRF in the plasma of women in the third trimester of pregnancy (10,18–22). Great variation exists in the absolute levels of the peptide measured and this may reflect, in part, the different assay and extraction systems used.

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Authors and Affiliations

  1. Department of Biochemistry & Physiology School of Animal and Microbial Sciences, University of Reading, UK

    E. A. Linton, C. D. A. Wolfe, D. P. Behan & P. J. Lowry

  2. Department of Community Medicine, St. Thomas’s Hospital Medical School, London, UK

    C. D. A. Wolfe

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  1. The University of Texas Southwestern Medical Center at Dallas, Dallas, Texas, USA

    John C. Porter

  2. Institute of Experimental Endocrinology, Bratislava, Czechoslovakia

    Daniela Ježová

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Linton, E.A., Wolfe, C.D.A., Behan, D.P., Lowry, P.J. (1990). Circulating Corticotropin-Releasing Factor in Pregnancy. In: Porter, J.C., Ježová, D. (eds) Circulating Regulatory Factors and Neuroendocrine Function. Advances in Experimental Medicine and Biology, vol 274. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-5799-5_9

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