Antibodies to Neuropeptides: Biological Effects and Mechanisms of Action
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After the discovery of the conventional neurotransmitters, it became clear that peptides also play an important role as intercellular messengers in the nervous system. Over the past three decades, hundreds of biologically active peptides have been isolated from or identified in brain tissue. These studies were usually directly followed by the identification of the sites of peptide production, storage and release with the aid of radioimmunoassays, immunocytochemistry, and hybridochemistry. In addition to such data, ligand binding studies may generate cues as to the organs or cells that may be influenced by a particular neuropeptide. In contrast to the relative ease with which the biological effects of a peptide are established, studies on the physiological roles of a peptide are complicated and often hampered by the lack of appropriate tools. It is conceivable that a physiological role of a neuropeptide is demonstrated most convincingly by studying the derangements caused by blockade of peptidergic signal transfer by the use of specific peptide receptor antagonists.
KeywordsGlutamate Decarboxylase Neuronal Uptake Corticosterone Secretion Antibody Uptake Noradrenergic Axon
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